Nucleic Acid Aptamer
Quantum dot-nucleic acid/aptamer bioconjugate based fluorimetric biosensors
... vary significantly from target to target and assay types. In general, the detection limits achieved for macromolecular targets are significantly lower, by ~ 3 orders of magnitudes, than those for small- molecule targets ...
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Nucleic Acid Aptamer-Guided Cancer Therapeutics and Diagnostics: the Next Generation of Cancer Medicine
... Apt, aptamer; AAP, activatable aptamer probe; CEA, carcinoembryonic antigen; Control, Ctrl; CSC, cancer stem cell; CT, computed tomography; DNAPK, DNA-activated protein kinase catalytic polypeptide; DOX, ...
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<p>Nucleic Acid Aptamer: A Novel Potential Diagnostic and Therapeutic Tool for Leukemia</p>
... multifunctional nucleic acid aptamers have shown the superiority over monoclonal antibodies and might be excellent alternatives or supplements to mono- clonal antibodies in theranostics (therapy and ...
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Immunogenicity of porcine circovirus type 2 nucleic acid vaccine containing CpG motif for mice
... the nucleic acid vac- cine containing 18 CpG, kept at a higher level through- out the immunization and decreased slowly, after challenge, it increased rapidly and could maintain a lon- ger ...
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Aptamers: Diagnostic and Therapeutic Applications
... DNA aptamer isolated against an isoleucyl tRNA synthetase enhanced editing activity ...the aptamer can physically dock with the ...the aptamer is high, the therapeutically relevant effect will likely ...
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Properties of Maedi Nucleic Acid and the Presence of Ribonucleic Acid- and Deoxyribonucleic Acid-Dependent Deoxyribonucleic Acid Polymerase in the Virions
... Properties of Maedi Nucleic Acid and the Presence of Ribonucleic Acid- and Deoxyribonucleic Acid-Dependent Deoxyribonucleic Acid Polymerase in the Virions Received for publication 22 Mar[r] ...
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An Introduction to Peptide Nucleic Acid
... PNA/nucleic acid duplex leaves the T m largely independent of salt concentration (Figure 3) ...a nucleic acid target despite the presence of competing secondary structure ...
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Targeting Nucleic Acid Junctions Using Triptycene-Based Molecules
... by nucleic acid binding proteins, we synthesized a new class of triptycene molecules containing amino acids commonly found at the protein-nucleic acid ...amino acid residues such as ...
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The relation between cell wall protein and nucleic acid synthesis in tall pea plants treated with a growth retardant AMO-1618.
... Cherry(l965). Homogenize the 2 gm of P -labeled tissue in a solution containing 40 ml 0.01 M Tris, pH 7.6, 0.06 M KCl, 0.01 M MgClg: 1 ml bentonite (40 mg/ml); 4.6 ml 11% Dupanol and 60 ml phenol with a Sorvall ...
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Whole body composition of Xenopus laevis larvae: implications for lean body mass during development
... larval Ambystoma tigrinum, in which DNA content was linearly correlated with wet mass (A. W. Smits, unpublished data). Although few studies exist which have correlated nucleic acid content with wet or dry ...
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PNA Biosensors for Nucleic Acid Detection
... silicon chip) should further enhance the discriminative power of nucleic acid hybridization tests, and would allow high throughput detection of multiple sequences in a single experiment. Arrays of up to ...
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Search for a Prion-Specific Nucleic Acid
... limited proteolysis in the presence of detergent (44). Although the recovery of prion infectivity in these experiments was good, the protein concentration was so high that nucleic acid analysis was ...
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Polysaccharides as initiators of nucleic acid polymerization
... acids—D-glucuronic acid and D-galacturonic acid. D- glucuronic acid is common in hemicellulose polysaccha- rides, whereas D-galacturonic acid in the form of galac- turonans is the main ...
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Virion nucleic acid of Ebola virus.
... At the outset of this project, no data were available on the nature of the Ebola virus genome, and our analysis considers whether i the virion nucleic acid is RNA or DNA, ii the genome i[r] ...
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Nucleic acid chaperons: a theory of an RNA-assisted protein folding
... amino acid replacement, and that if such changes affect protein folding, this would have restrained such nucleotide replacements ...amino acid co-locations is less than 200 (20 × 20/2), and the pos- sible ...
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Algorithms for nucleic acid sequence design
... engineered nucleic acid systems [4–7] including self-assembling two- and three-dimensional structures, triggered self-assembly mechanisms, computational devices, machines, scaffolds, and ...these ...
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The concept of RNA-assisted protein folding: the role of tRNA
... Figure 5 Interaction between t-RNA Conformers. There are many different forms (conformers) of t-RNAs in addition to the canonical “ cloverleaf ” configuration. The hairpin-like structure (a) is suitable for inter- ...
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Real Time Detection of Influenza A, Influenza B, and Respiratory Syncytial Virus A and B in Respiratory Specimens by Use of Nanoparticle Probes
... (Nanosphere Inc., Northbrook, IL) to detect influenza A virus, influenza B virus, and respiratory syncytial virus A and B (RSV A/B) from clinical nasopharyngeal swab specimens. Detection of viral RNA in both tests is ...
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Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles
... Abstract: Self-amplifying RNA or RNA replicon is a form of nucleic acid-based vaccine derived from either positive-strand or negative-strand RNA viruses. The gene sequences encoding structural proteins in ...
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Molecular Beacons of Xeno-Nucleic Acid for Detecting Nucleic Acid
... cleic acid greatly helped us study biological evolution, gene analysis, disease diagnosis, as well as drug dis- ...clear acid. Among these analogs, peptide nucleic acid (PNA) and locked ...
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