Oleanolic Acid
Oleanolic acid liposomes with polyethylene glycol modification: promising antitumor drug delivery
... of oleanolic acid, the lipid phase was dripped into the aqueous phase under magnetic stirring, using a 4 µ m diam- eter stainless steel needle attached to a 1 mL glass ...
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Antioxidant Properties of the Oleanolic Acid Isolated from Cassia auriculata (Linn)
... Nitric oxide (NO) is a potent pleiotropic mediator of physiological processes such as smooth muscle relaxation, neuronal signaling, inhibition of platelet aggregation and regulation of cell mediated toxicity. It is a ...
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Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity
... Results: Five acyl oleanolic acid‑uracil conjugates were synthesized. Most of the IC 50 values of these conjugates were lower than 10.0 μM, and some of them were even under 0.1 μM. Cytotoxicity selectivity ...
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S adenosyl L methionine, trehalose and oleanolic acid in few plants
... In the present communication, we have made com- parative studies on AdoMet, trehalose and oleanolic acid content among the above mentioned medicinally impor- tant plants. For our experiments we have taken ...
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Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO 1 signaling
... [9,10]. Oleanolic acid (OA), a known activator of Nrf2, is a natural pentacyclic triterpenoid that has he- patoprotective, anti-inflammatory, antioxidant, and anti- cancer activities ...
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SCREENING OF ANTIMICROBIAL POTENTIAL OF OLEANOLIC ACID ISOLATED FROM VISCUM ARTICULATUM BURM
... isolated oleanolic acid against ...isolated oleanolic acid is not so strong as compared with antimicrobial drugs that are clinically used, although isolated oleanolic acid showed ...
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Synthesis and Anti-Tumor Activity of Oleanolic Acid Derivatives
... In this paper, we put together the structural modification of pentacyclic triterpene compounds suggested by Meng’s study team, the antitumor compounds which have entered clinical research (Figure 1), and the computer ...
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Preparation, characterization, and in vitro/vivo studies of oleanolic acid-loaded lactoferrin nanoparticles
... Abstract: Oleanolic acid (OA), a pentacyclic triterpene, is used to safely and economically treat hepatopathy. However, OA, a Biopharmaceutics Classification System IV category drug, has low bioavailability ...
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High-Performance Thin Layer Chromatography Method for Identification and Quantification of Oleanolic Acid in the Roots of Achyranthes aspera Linn
... regression. Oleanolic acid was not detectable in UV light or fluorescence therefore it has been transformed in detectable substances to evaluate the TLC ...sulfuric acid reagent for <5 ...
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QUANTIFICATION OF OLEANOLIC ACID AND BETULINIC ACID BY TLC AND BRINE SHRIMP LETHALITY ASSAY OF NYMPHAEA STELLATA WILLD. LEAVES
... Pure oleanolic acid and betulinic acid were procured from Himedia Laboratories Pvt. Ltd., Mumbai, India. Brine shrimp eggs were purchased from Ocean Star International Inc., Snowville, UT, USA. Other ...
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DEVELOPMENT AND VALIDATION OF LC MS/MS METHOD FOR THE SIMULTANEOUS DETERMINATION OF ΒETA SITOSTEROL, THYMOL AND OLEANOLIC ACID IN LEUCAS ASPERA LINN
... All the chemicals used in the experiments were of LCMS grade. Standard beta-sitosterol (98.0% purity), standard thymol (98.0% purity) and standard oleanolic acid (98.0% purity) were procured from sigma ...
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Development of validated HPTLC method for quantification of oleanolic acid from bark of Madhuca longifolia
... of oleanolic acid which suggested an excellent precision and reproducibility of the method (Table ...that oleanolic acid is stable during the extraction procedure as well as during ...of ...
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Ionic Liquid Based Ultrasonic Assisted Extraction of Oleanolic Acid from Grape Seeds
... DOI: 10.4236/oalib.1104148 2 Open Access Library Journal waste [1] [2]. Grape seeds are by-products of the wine and grape juice industry. These seeds contain lipid, protein, carbohydrate, polyphenols and triterpenoids ...
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Optimized formulation of multivesicular liposomes loaded with oleanolic acid enhanced anticancer effect in vitro
... Abstract: Invasion and metastasis are the main causes leading to the death of patients with hepatocellular carcinoma (HCC). Multivesicular liposomes loaded with oleanolic acid (OA- MVLs) have been well ...
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Estimation of ursolic acid and oleanolic acid from leaves of Plumeria obtusa by HPTLC method after iodine derivatization
... Sr. No. Parameters Ursolic acid Oleanolic acid 1 Limit of Detection 160ng/spot 320 ng/spot 2 Limit of Quantification 389.65 ng/spot 960.31ng/spot 3 Linearity range 400-1400 ng/spot 1200-4200 ng/spot ...
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Synthesis and Anti-Tumor Activity of Oleanolic Acid Derivatives
... In this essay, we combined the structural modification of pentacyclic triterpene compounds suggested by Meng’s research team with the antitumor compounds which have entered the clinical study (Figure 1) and the computer ...
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Self-microemulsifying drug delivery system for improved oral bioavailability of oleanolic acid: design and evaluation
... of oleanolic acid in which was ...of oleanolic acid from the SMEDDS was compared with oleanolic acid solution containing the same amount of drug dissolved in ...
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Oleanolic Acid Induces Apoptosis and Necrosis in LO2 Cells
... Normal human hepatic cells were exposed to different concentrations of oleanolic acid and the results demonstrated that oleanolic acid induced cell death in a concentration- and time-de[r] ...
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Preparation, characterization, and in vivo pharmacokinetics of nanostructured lipid carriers loaded with oleanolic acid and gentiopicrin
... Because of its feasibility, accuracy, and high reliability, we chose the carbon tetrachloride model of acute liver injury in the rat for our experiments. Compared with controls, ALT and AST were significantly elevated in ...
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The Electrochemical Redox Mechanism and Antioxidant Activity of Oleanolic Acid Based on Multi-walled Carbon Nanotuber Screen-printing Electrode
... of Oleanolic acid was oxidated to be ketone compound via DPPH free radical according to two equations as shown in ...that oleanolic acid had a strong antioxidant activity, and it played a ...
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