Oncogenic K-Ras
Conditional expression of oncogenic K ras from its endogenous promoter induces a myeloproliferative disease
... of oncogenic K-ras in hematopoietic stem cells might be expected to engender not only myeloid proliferation but also megakaryocyte hyperplasia or lymphoprolif- erative ...the ras/MAP kinase ...
12
Inactivation of Icmt inhibits transformation by oncogenic K Ras and B Raf
... of K-Ras–transfect- ed cells to form colonies in soft ...for Ras transformation and are sometimes found at increased concentrations in Ras-transformed cells (35, ...
13
Original Article MicroRNA-143 shows tumor suppressive effects through inhibition of oncogenic K-Ras in pituitary tumor
... addition, K-Ras, one of the most important oncogenes involved in many kinds of cancers, was found to be suppressed by miR-143 in pituitary ...of K-Ras greatly reversed the suppressive effect ...
10
WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer
... CRC, oncogenic K-RAS mutation en- hances CSC activation and cooperatively promotes tumorigenesis by increasing Wnt/β-catenin pathway ac- tivation ...of RAS [15, 24, ...by oncogenic ...
13
Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer
... The oncogenic K-Ras can transform various mammalian cells and plays a critical role in development of pancreatic ...in K-Ras transformation remains to be ...of K-Ras in a ...
11
Targeting Bcl-2 stability to sensitize cells harboring oncogenic ras
... an oncogenic ras were extremely sensitive to the inhibition of protein kinase C (PKC) and Bcl-2 could antagonize this apoptotic ...harboring oncogenic K-ras to apoptosis triggered by ...
10
Targeting Autophagy Addiction in Cancer
... and oncogenic K-Ras both directly and indirectly ...possesses K-Ras mutations, we noted that all human-derived PDAC cell lines examined showed elevated basal ...autochthonous ...
5
Wild-type N-Ras complements mutant K-Ras in pancreatic cancer cell lines but K-Ras has a specific role in cell cycle independent regulation of G2 cyclins
... active K-Ras is bound to the cytoplasmic ...mutant K-Ras containing cells: including in the lung, pancreas (Lu et ...including K-Ras mutations (Lu et ...total K-Ras ...
175
Characterization of Ras-driven melanoma : understanding the relationship between acute loss of p16Ink4a and somatic activation of Ras in melanomagenesis
... Receptor tyrosine kinases have a predominant role in transmitting signals from extracellular receptors to intracellular effectors. The c-KIT gene encodes a RTK that serves as the receptor for stem cell factor (SCF). ...
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Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras
... Oncogenic Ras stimulates macropinocytosis, a clathrin-independent endocytosis that increases the uptake of extracellular ...by Ras-expressing cells can support growth and survival under the ...
13
Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth
... to Ras V12 , sec15 clones (3.85±5.8%; N=408 caspase- Fig. 3. Ras V12 cells stimulate secretion through ...(WT), Ras V12 or Ras V12 , sec15 mutant clones (green, middle panels) after pulse ...
11
Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism.
... Specifically, each displays oncogenic activity in the form of ras cooperativity, each encodes proteins that can trans-activate transcription as measured by activation of the adenovirus E[r] ...
9
The Gain of Function of p53 Mutant p53S in Promoting Tumorigenesis by Cross-talking with H-RasV12
... researches found that p53 inactivation induced the RasV12 pathway through diverse mechanisms in- volving the p53 targets BTG2 and ATF3, which in turn facilitated the malignant transformed phenotype of cells and the ...
10
Prospective Development of Small Molecule Targets to Oncogenic Ras Proteins
... Additionally, our increased knowledge of the conformational and dynamics changes seen for Ras-related mutant proteins should also be exploited in subsequent design strategies to target s[r] ...
5
Quantitative Analysis of Ras Oncogene Isoforms Using Decision Tree and Support Vector Machine
... each Ras isoform is quite similar to the shape of Gaussian function, therefore ...of K-Ras and N-Ras is lower than that of the ...that K-Ras and N-Ras have similar amino ...
8
Impact of Mutations on K Ras p120GAP Interaction
... with Ras Switch I and Switch II regions (containing amino acids 30 - 40, and 60 - 70, respectively), and stabilizes these two regions dur- ing the hydrolytic process (Figure ...the K-Ras Switch I ...
9
Real-time in vivo imaging of p16Ink4agene expression: a new approach to study senescence stress signaling in living animals
... It is, however, clear that all aspects of p16 INK4a regula- tion cannot be explained by the factors described here, and that the p16 INK4a gene is subject to multiple levels of control [15,38,39,64-74]. Nonetheless, we ...
8
Deletion of cyclooxygenase-2 inhibits K-ras–induced lung carcinogenesis
... Furthermore, our findings suggest that COX-2 mediates K-Ras–induced lung cancer through the MAPK pathway. The MAPK/Erk signaling cascade is activated by a wide variety of receptors involved in cell growth ...
11
K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis
... which K-Ras protein is stabilized via estrogen signaling through the ER-α36 ...stabilize K-Ras specifically via estrogen signaling. Estrogens stabilize K-Ras via inhibition of ...
13
Deletion of C/EBPß in Oncogenic Ras-Driven Skin Tumors is a Synthetic Lethal Event Promoting p53-Dependent Apoptosis, a Type I Interferon Response, and Tumor Regression.
... dominant oncogenic drivers in human cancer ...of Ras mutation; for example, >90% of pancreatic cancers contain mutated Ki-RAS ...mutated, oncogenic Ras signaling promotes ...
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