Oncolytic vaccinia
A cancer-favoring oncolytic vaccinia virus shows enhanced suppression of stem-cell like colon cancer
... cancer-favoring oncolytic vaccinia virus, by first evolving vaccinia virus from the tumor mass and then inactivating the vTk ...wild-type vaccinia virus ...
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Inducible Gene Expression in Tumors Colonized by Modified Oncolytic Vaccinia Virus Strains
... All strains were derived from the GLV-1h68 oncolytic vaccinia virus strain (13). This strain was shown to be highly effective in numerous tumor models (13–24) and is currently being tested for safety and ...
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Oncolytic vaccinia virus combined with radiotherapy induces apoptotic cell death in sarcoma cells by down-regulating the inhibitors of apoptosis
... of oncolytic virotherapy (OV) delivered by isolated limb ...of oncolytic vaccinia virus (GLV-1h68) and radiotherapy demonstrated synergistic ...radiation. Oncolytic virotherapy represents an ...
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Combination treatment with oncolytic Vaccinia virus and cyclophosphamide results in synergistic antitumor effects in human lung adenocarcinoma bearing mice
... during oncolytic virotherapy using GLV-1h68 and especially its derivative GLV-1h108, which encodes a single chain antibody against VEGF, tumor-associated hematoma disappeared ...with oncolytic ...
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<p>An Oncolytic Vaccinia Virus Armed with GM-CSF and IL-24 Double Genes for Cancer Targeted Therapy</p>
... Due to a genetically unstable and complex biological system, which has the ability to adapt to and multiply in severe and changing environments, cancer still remains a life-threatening disease in the majority of cases ...
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Oncolytic vaccinia virus combined with radiotherapy induces apoptotic cell death in sarcoma cells by down-regulating the inhibitors of apoptosis.
... of oncolytic virotherapy (OV) delivered by isolated limb ...of oncolytic vaccinia virus (GLV-1h68) and radiotherapy demonstrated synergistic ...radiation. Oncolytic virotherapy represents an ...
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Immunogenicity of oncolytic vaccinia viruses JX-GFP and TG6002 in a human melanoma in vitro model: studying immunogenic cell death, dendritic cell maturation and interaction with cytotoxic T lymphocytes
... Abstract: Oncolytic virotherapy is an emerging immunotherapeutic modality for cancer ...treatment. Oncolytic viruses with genetic modifications can further enhance the oncolytic effects on tumor ...
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Antiangiogenic Arming of an Oncolytic Vaccinia Virus Enhances Antitumor Efficacy in Renal Cell Cancer Models
... Oncolytic vaccinia viruses have shown compelling results in preclinical cancer models and promising preliminary safety and antitumor activity in early clinical ...armed oncolytic vaccinia ...
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Oncolytic vaccinia virus GLV 1h68 strain shows enhanced replication in human breast cancer stem like cells in comparison to breast cancer cells
... of oncolytic vaccinia virus GLV-1h68 strain, tumors were established in the mammary fat pads of athymic nude mice by implantation of 5 × 10 3 sorted ALDEFLUOR-positive and ALDEFLUOR-negative GI- 101A ...
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Growth inhibition of different human colorectal cancer xenografts after a single intravenous injection of oncolytic vaccinia virus GLV 1h68
... that oncolytic vaccinia virus GLV-1h68 efficiently infected, replicated in, and lysed a variety of human CRC lines in ...observed oncolytic activity of GLV-1h68 occurred in both CRC cell types ...
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Theranostic Potential of Oncolytic Vaccinia Virus
... replication, oncolytic viruses expressing fluorescent proteins have been tested pre-clinically for a variety of putative clinical ...viruses, oncolytic viruses expressing fluorescent proteins might also be ...
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Oncolytic vaccinia virus as a vector for therapeutic sodium iodide symporter gene therapy in prostate cancer.
... that vaccinia virus and radiation acted synergistically by modulating JNK/TNFα signalling (33), we did not see evidence of this effect in prostate cancer cell lines (Fig ...
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Replication efficiency of oncolytic vaccinia virus in cell cultures prognosticates the virulence and antitumor efficacy in mice
... light-emitting oncolytic VACV, GLV-1h68, which was constructed by inserting three foreign gene expression cassettes encoding Renilla luciferase-Aequorea green fluorescent protein fusion pro- tein (RUC-GFP), ...
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Microglia and astrocytes attenuate the replication of the oncolytic vaccinia virus LIVP 1 1 1 in murine GL261 gliomas by acting as vaccinia virus traps
... responder” models for oncolytic virotherapy with VACV LIVP 1.1.1. By searching for explanations for this find- ing we detected that microglia and astrocytes were recruited to the tumor sites independent of ...
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Colonization of xenograft tumors by oncolytic vaccinia virus (VACV) results in enhanced tumor killing due to the involvement of myeloid cells
... by oncolytic VACV is an impor- tant effector mechanism which directly contributes to the therapeutic effect of ...lytic vaccinia virotherapy through ...
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<p>Embelin Promotes Oncolytic Vaccinia Virus-Mediated Antitumor Immunity Through Disruption of IL-6/STAT3 Signaling in Lymphoma</p>
... In the previous work, we have determined that embelin is capable of rendering acute myeloid leukemia (AML) cells more sensitive to trail via repressing NF- κ B both in vitro and in vivo, 27 which raises the possibility ...
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Synergistic suppression effect on tumor growth of acute myeloid leukemia by combining cytarabine with an engineered oncolytic vaccinia virus
... Notes: (A) schematic structure of recombinant oVV and oVV-ing4. all viruses were constructed through homologous recombination between pcB-transgene and wild- type vaccinia virus (VacV) in heK293a cells. T7 ...
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Functional hyper IL 6 from vaccinia virus colonized tumors triggers platelet formation and helps to alleviate toxicity of mitomycin C enhanced virus therapy
... of oncolytic vaccinia virus strains appear to be one of the most promising against a wide range of solid tumors ...engineered oncolytic vac- cinia virus strains have already been carried out [19,34], ...
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Isolated limb perfusion with biochemotherapy and oncolytic virotherapy combines with radiotherapy and surgery to overcome treatment resistance in an animal model of extremity soft tissue sarcoma.
... of oncolytic virotherapy when delivered by ILP and, in this study, we report further improvements from combining ILP-delivered oncolytic virotherapy with radiation and surgical ...an oncolytic ...
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Vaccinia virus GLV 1h153 is a novel agent for detection and effective local control of positive surgical margins for breast cancer
... new oncolytic vaccinia virus engineered to express hNIS to identify positive surgical margins of resected mammary fat pad tumors in an orthotopic breast cancer model ...
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