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OPG–RANKL–RANK-system

RANK/RANKL/OPG system in the intervertebral disc

RANK/RANKL/OPG system in the intervertebral disc

... of RANKL on matrix metabolism, rat IVD cells were treated with exogenous ...exogenous RANKL does not activate NF-κ B or induce the expression of genes en- coding catabolic ...of RANK-positive sub- ...

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Disturbance of the OPG/RANK/RANKL pathway and systemic inflammation in COPD patients with emphysema and osteoporosis

Disturbance of the OPG/RANK/RANKL pathway and systemic inflammation in COPD patients with emphysema and osteoporosis

... of OPG was greater in COPD patients who combined with osteopenia/osteoporosis than those without low BMD and related inversely to hip BMD, but the level of RANKL and the ratio of RANKL/OPG ...

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The RANK/RANKL/OPG system in tumorigenesis and metastasis of cancer stem cell: potential targets for anticancer therapy

The RANK/RANKL/OPG system in tumorigenesis and metastasis of cancer stem cell: potential targets for anticancer therapy

... the system is highly associated with tumor invasiveness and ...triad system in cancer cell devel- opment and metastasis, scientists are striving to discover therapeutic agents targeting these TNF-related ...

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Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration

Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration

... the RANK/RANKL/OPG system exists (evaluated at both mRNA and protein levels) in AF and NP cells isolated from human IVD tissues, and that these levels were regulated by proin- flammatory ...

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Achyranthes bidentata extract exerts osteoprotective effects on steroid induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling

Achyranthes bidentata extract exerts osteoprotective effects on steroid induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling

... Steroid-induced osteonecrosis of the femoral head (ster- oid-induced ONFH) is a serious complication in patients who have received steroids for the treatment of various diseases, including nephrotic syndrome, renal ...

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Biology of RANK, RANKL, and osteoprotegerin

Biology of RANK, RANKL, and osteoprotegerin

... Bone remodeling becomes perturbed in a variety of patho- logic conditions that affect the skeleton, including post- menopausal osteoporosis and rheumatoid arthritis, in which there is local and/or systemic alteration in ...

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RANK-RANKL signalling in cancers

RANK-RANKL signalling in cancers

... glycoproteins, RANKL and its receptor RANK, members of the TNF and TNFR superfamilies, have stimulated the interest of the scientific ...community. RANK is frequently expressed by cancer cells in ...

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Original Article Berberine suppresses osteoclastogenesis and osteolysis in a mouse model

Original Article Berberine suppresses osteoclastogenesis and osteolysis in a mouse model

... The RANKL/RANK/osteoprotegerin (OPG) sys- tem is an important recent discovery in the osteoclast ...field. RANK combined with RANKL can activate signaling in precursor cells and dif- ...

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Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy

Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy

... the ECL-Plus chemiluminescent detection system (Perkin- Elmer, MA, USA). Images of the membranes were ac- quired, scanned, and analyzed using Quantity One software (v4.6.6, Bio-Rad). For RT-PCR analysis ...

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Gene polymorphisms in RANKL/RANK/OPG pathway are associated with ages at menarche and natural menopause in Chinese women

Gene polymorphisms in RANKL/RANK/OPG pathway are associated with ages at menarche and natural menopause in Chinese women

... Approximately 5 mL of venous blood was collected from all of the participants after a minimum of 10 h fasting and stored in tubes containing 100 μL of 10% ethylene diaminetetraacetic acid (EDTA). Genomic DNA was ...

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Osteoprotective effects of vitamin D(3) in diabetic mice is VDR-mediated and regulated via RANKL/RANK/OPG axis

Osteoprotective effects of vitamin D(3) in diabetic mice is VDR-mediated and regulated via RANKL/RANK/OPG axis

... (RANK), RANK ligand (RANKL), and its decoy receptor osteoprotegerin (OPG) play an im- portant role in the maintaining of structure and functional properties of bone ...triad ...

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Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway

<p>Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway</p>

... Ten larvae were randomly pooled as one replicate at the termination of experiments and were maintained in Trizol reagent (Invitrogen, USA) at − 80 °C. Total RNA was iso- lated using Trizol reagent and digested using ...

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(5R) 5 Hydroxytriptolide (LLDT 8) inhibits osteoclastogenesis via RANKL/RANK/OPG signaling pathway

(5R) 5 Hydroxytriptolide (LLDT 8) inhibits osteoclastogenesis via RANKL/RANK/OPG signaling pathway

... recombination RANKL. Among them, the osteoclasts induced by RANKL were larger in both volume and ...of RANKL and ...of RANKL and M-CSF, and LLDT-8 decreased the osteoclas- ...in RANK/ ...

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Original Article Expression of osteoprotegerin, RNAK and RANKL genes in femoral head avascular necrosis and related signaling pathway

Original Article Expression of osteoprotegerin, RNAK and RANKL genes in femoral head avascular necrosis and related signaling pathway

... To quantify the gene expression of OPG, RANK and RANKL genes, we employed fluorescent qPCR technique. The in vitro reverse transcrip- tion was performed using RNA as the template. PCR system ...

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RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives

RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives

... of OPG at supraphysiological concentrations ...cells-derived OPG could be more com- plex in vivo due to the simultaneous presence of RANKL and ...Although OPG binds RANKL and TRAIL with ...

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Circulating Receptor Activator of Nuclear Factor kB Ligand and triglycerides are associated with progression of lower limb arterial calcification in type 2 diabetes: a prospective, observational cohort study

Circulating Receptor Activator of Nuclear Factor kB Ligand and triglycerides are associated with progression of lower limb arterial calcification in type 2 diabetes: a prospective, observational cohort study

... the RANKL/RANK/ OPG system. RANKL, which is produced by osteo- blasts, vascular cells, stromal cells, T-cells, macrophages and monocytes, binds to its receptor RANK which is ...

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TNF Super Family Members OPG, RANKL, RANK  and Osteoporosis: a link

TNF Super Family Members OPG, RANKL, RANK and Osteoporosis: a link

... this system primarily by stimulating M-CSF production ,which further trigger the pool of preosteoclastic cells and by directly increasing RANKL expression, thus augmenting NF-κB ; and inhibiting osteoblast ...

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The relationship between osteoclastogenic and anti-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissues

The relationship between osteoclastogenic and anti-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissues

... the RANK/RANKL/OPG system ( TNFRSF11A, TNFSF11, TNFRSF11B) and 5 osteoclast specific genes (ITGB3, OSCAR, CTSK, ACP5, CALCR) in human OP and OA bone tissue was ...

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Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines

Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines

... of RANKL on signal transduction molecules were determined by western blot ...by RANKL altered the cell morphology to the mesenchymal phenotype in normal breast epithelial and breast cancer ...addition, ...

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Lanthanum carbonate prevents accelerated medial calcification in uremic rats: role of osteoclast like activity

Lanthanum carbonate prevents accelerated medial calcification in uremic rats: role of osteoclast like activity

... as RANKL and inhibitory cytokines such as ...of RANKL and OPG on bone resorption, the RANKL/ OPG ratio is a major determinant of bone mass and bone ...with RANKL showed a dose- ...

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