Organic anion-transporting polypeptide
Study on the Expression of Organic Anion Transporting Polypeptide (oatp2a1) in Rat with Spleen Deficiency Syndrome and the Exploration of Clinical Significance
... of organic anion transporting polypeptide (oatp) superfamily member 2a1 (oatp2a1) mRNA in rat with spleen deficiency syndrome and the significance in transportation and transformation of ...
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Effects of Organic Anion Transporting Polypeptide (OATP1B1/SLCO1B1) Genetic Polymorphism on Statin Therapy
... of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion transporting polypeptide 1B1 (OATP1B1) multidrug resistance 1 and OATP1B1 ...
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The Effect of Cangfudaotan Tang on Expression of Organic Anion Transporting Polypeptide (oatp4a1) in Rat Ovary and Uterus Tissues of Obese PCOS
... that Organic Anion Transporting Polypeptide might be the material basis involved in transportation and transformation of ...ganic Anion Transporting Polypeptide is ...
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Localization of organic anion transporting polypeptide (Oatp) 1a4 and Oatp1c1 at the rat blood-retinal barrier
... Background: Organic anion transporting polypeptide (Oatp) transporters at the blood – brain barrier (BBB) and the blood-retinal barrier (BRB), which consists of retinal capillary endothelial ...
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Unique expression features of cancer-type organic anion transporting polypeptide 1B3 mRNA expression in human colon and lung cancers
... cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3, [GenBank: NM_019844 (for SLCO1B3, gene symbol) and GenBank: AB669023 (for the alternative region)] in human colon and lung ...
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Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood–brain barrier in Sprague–Dawley rats
... The translational challenges associated with targeting P-gp indicate a need for a change in thought regarding BBB transporters. Our laboratory has proposed that a more rational strategy would be to target SLC trans- ...
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Effects of Cangfudaotan Tang on Expression of Organic Anion Transporting Polypeptide (oatp2b1) in Liver and Kidney Tissues of Rats with Phlegm Dampness Type Polycystic Ovary Syndrome (PCOS)
... indicates, organic anion transporter polypeptide (oatp) can efficiently transport a variety of foreign organisms, which plays an important role in transporta- tion and transformation of phlegm ...
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P-glycoprotein- and organic anion-transporting polypeptide-mediated transport of periplocin may lead to drug–herb/drug–drug interactions
... whereas organic anion transporters, organic anion-transporting polypeptides (OATPs), and organic cation transporters are members of the solute-carrier ...
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Organic anion transporting polypeptide 1B3 (OATP1B3) is overexpressed in colorectal tumors and is a predictor of clinical outcome
... Within individual tumor grades, OATP1B3 expression was associated with improved 5-year survival, but not recurrence in patients with poorly differentiated tumors.. Conclusion: OATP1B3 [r] ...
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Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
... Organic anion transporting polypeptides (human: OATP, gene SLCO; rodents: Oatp, gene Slco) belong to the superfamily of the solute carrier class of organic anion transporters ...of ...
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EFFECT OF PINEAPPLE (ANANAS COMOSUS) AND UZIZA (PIPER GUINEENSE) EXTRACTS ON FEXOFENADINE BIOAVAILABILITY: POSSIBLE ROLE OF P-GLYCOPROTEIN (P-GP) AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs)
... implicated as a substrate for the efflux transporter, P-glycoprotein (P-gp), in addition to the influx transporter, organic anion transporting polypeptide (OATP). Further to this, data has ...
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Does ethnic variability exist in the systemic exposures of oatp1a2 substrates?fexofenadine in taiwanese?
... human organic anion‑transporting polypeptide 1A2 (OATP1A2): Implications for altered drug disposition and central nervous system drug ...
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Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets
... Figure 1 ribbon representation of the three-dimensional model of organic anion-transporting polypeptide 1B3. TM domains, a probable substrate binding site and the conserved amino acid side ...
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Primary and secondary thyroid hormone transporters
... activity in comparison to the wild type mice [10-12]. On the basis of these data it was assumed that addi- tional TH transporters ( “ secondary TH transporters ” ) or differences in their expression patterns and ...
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Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide
... as organic anion transporter 1 (OAT1), OAT3, organic anion transporting polypeptide 1B1 (OATP1B1), OATP1B3, organic cation transporter 1 (OCT1), OCT2, P-glycoprotein ...
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Molecular and biological characterization of the Amblyomma americanum organic anion transporter polypeptide
... Consistent with vertebrate Oatp/OATP genes that show multiple tissue expression patterns (St-Pierre et al., 2002; Gao et al., 2005; Choudhuri et al., 2003), our RT-PCR expression analyses data revealed that Aam Oatp mRNA ...
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Structural and functional studies of ligandin, a major renal organic anion binding protein
... phenolsulfonphthalein [PSP], phlorizin, glutathione [GSH], p-amino hippurate (PAH), probenecid, conjugated bilirubin, and BSP-GSH) to a nonalbumin-containing protein fraction (Y), which precipated on addition of ...
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Role of chloride and intracellular pH on the activity of the rat hepatocyte organic anion transporter
... Previous studies in cultured rat hepatocytes and isolated perfused rat liver have revealed that initial uptake of these organic anions is markedly reduced upon removal of Cl- from the me[r] ...
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First evidence of epithelial transport in tardigrades: a comparative investigation of organic anion transport
... PAH is a prototypical substrate of the classic organic anion transport system (i.e. the SLC22 subfamily) and was shown to be an effective inhibitor of CPR transport in both H. crispae and S. gregaria (~40% ...
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3 Ammonio 2,6 dibromopyridine bromide hemihydrate
... The organic cation, bromide anion and interstitial water molecule are held together by hydrogen bonding, bromine±bromine interactions and by a special type of electrostatic interaction between aryl bromine ...
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