ornithine decarboxylase
Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor
... Ornithine decarboxylase (ODC), cyclin D1 (CCND1) and antizyme inhibitor (AZI) promote cell growth. ODC and CCND1 can be degraded through antizyme (AZ)- mediated 26S proteasomal degradation. This paper ...
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Cloning, expression and characterization of the ornithine decarboxylase gene from Dictyostelium discoideum
... Ornithine decarboxylase (ODC, EC ...L- ornithine is converted to putrescine (Heller et ...of ornithine by ODC is the only pathway for de novo synthesis of polyamines in mammals and higher ...
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RNA Interference-Mediated Silencing of Ornithine Decarboxylase and Spermidine Synthase Genes in Trypanosoma brucei Provides Insight into Regulation of Polyamine Biosynthesis
... S-adenosylmethionine decarboxylase (AdoMetDC) led to the upregulation of the AdoMetDC activator, prozyme, and ornithine decarboxylase (ODC) ...
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P Elements Inserted in the Vicinity of or Within the Drosophila snRNP SmD3 Gene Nested in the First Intron of the Ornithine Decarboxylase Antizyme Gene Affect Only the Expression of SmD3
... The Drosophila gene for snRNP SmD3 (SmD3) is contained in reverse orientation within the first intron of the Ornithine Decarboxylase Antizyme (AZ) gene. Previous studies show that two closely linked P ...
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Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes
... of ornithine decarboxylase (ODC) in the kidney increases after only 1 day of streptozotocin diabetes, and that the ODC inhibitor, difluoromethylornithine (DFMO), attenuates renal hypertrophy during the ...
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Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice
... cutaneous ornithine decarboxylase (ODC), the first enzyme in the polyamine-biosynthesis pathway, which drives continued proliferation and clonal expansion of initiated (mutated) cells, leading to ...
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Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma
... LIN28 has emerged as an oncogenic driver in a number of cancers, including neuroblastoma (NB). Overexpression of LIN28 correlates with poor outcome in NB, therefore drugs that impact the LIN28/Let-7 pathway could be ...
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Bulk Segregant Analysis Followed by High-Throughput Sequencing Reveals the Neurospora Cell Cycle Gene, ndc-1, To Be Allelic with the Gene for Ornithine Decarboxylase, spe-1
... for ornithine decarboxylase, ...of ornithine decarboxylase proteins from a variety of organisms, including wild-type Neurospora, indicates the mutated residue is highly ...
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Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep
... with multiple roles that include: 1) stabilization of DNA and DNA transcription; 2) stabilization of mRNA and mRNA translation for protein synthesis; 3) growth, proliferation and migration of cells; 4) stability of cell ...
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Localization of ornithine decarboxylase in mouse teeth An in vitro and in vivo study
... Int J IJ , lJiul '8 107 115 (199 1) 107 Original Article Localization of ornithine decarboxylase in mouse teeth An in vitro and in vivo study AMEL GRITLI LlNDE* and ANDERS LINDE Department of Oral Bio[.] ...
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Regulation of Adrenal Ornithine Decarboxylase by Adrenocorticotropic Hormone and Cyclic AMP
... observed 4 h after administration of these substances. Effects of ACTH and dibutyryl cyclic AMP were not secondary to stimulation of steroidogenesis, since hydrocortisone had no effect on adrenal ornithine ...
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The Inhibitory Effect of Curcumin on Ornithine Decarboxylase against Hepatic Carcinoma
... Curcumin the active component of turmeric is widely used as an anticancer agent for treating many human cancers. This study aimed at the extraction of curcumin from Curcuma Longa and investigates its therapeutic effect ...
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The ornithine decarboxylase gene of Caenorhabditis elegans: cloning, mapping and mutagenesis.
... The cDNA clone harboring the coding region of odr-I, pCECla, was linearized with ApaI (located at the 3' end of ode-I), transcribed with SP6 polymerase and translat[r] ...
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IN VITRO ANALYSIS OF ORNITHINE DECARBOXYLASE INHIBITORY ACTIVITY OF THE EXTRACTS OF EXCOECARIA AGALLOCHA L
... As the biosynthetic pathway of polyamine synthesis is heavily dependent on the activity of the enzyme ODC, it is understood that a decrease in the concentrations of polyamine levels could result in reduced cell growth. ...
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Endogenous ornithine decarboxylase/polyamine system mediated the antagonist role of insulin/PEG-CMCS preconditioning against heart ischemia/reperfusion injury in diabetes mellitus
... In this experiment, 60 diabetic rats were divided into six groups (each group = 10 rats): 1) Sham group; 2) I/R group: diabetic rats were anesthetized with 1% pentobarbital s[r] ...
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Aeromonas veronii, a new ornithine decarboxylase positive species that may cause diarrhea
... These included type strains of Vibrio, Photobacterium, and Aeromonas species with standing in nomenclature Table 3, the type strain of Plesiomonas shigelloides, and laboratory strains of[r] ...
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Effects of the sap of the common oleander Nerium indicum (Apocyanaceae) on male fertility and spermatogenesis in the oriental tobacco budworm Helicoverpa assulta (Lepidoptera, Noctuidae)
... We investigated the effects of sap of the common oleander Nerium indicum (Apocyanaceae) on male fertility and spermatogenesis in the oriental tobacco budworm Helicoverpa assulta. We found that continuous feeding of ...
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Induction of renal growth and injury in the intact rat kidney by dietary deficiency of antioxidants
... suppressible by chronic alkali therapy. Stimulation of renal growth could not be ascribed to increased intrarenal iron, induction of ornithine decarboxylase, or alterations in glomerular hemodynamics. ...
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The malignant phenotype in breast cancer is driven by eIF4A1 mediated changes in the translational landscape
... eIF4E is a well-established oncogene,10,11 and the translation of several oncogenic mRNAs with long or structured 5′UTRs, such as c-myc, cyclin D1 and ornithine decarboxylase ODC were sh[r] ...
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Evaluation of the rapid decarboxylase and dihydrolase test for the differentiation of nonfermentative bacteria
... A rapid medium for the detection of lysine and ornithine decarboxylase and arginine dihydrolase activity of 439 strains of gram-negative, nonfermenting bacteria was evaluated and compare[r] ...
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