osteoclast/bone surface
Ethanolic extract of Schizonepeta tenuifolia attenuates osteoclast formation and activation in vitro and protects against lipopolysaccharide induced bone loss in vivo
... for bone resorption activity. Once the multinucleated osteoclast attaches to the bone surface, its membrane becomes polar- ized and secretes both hydrogen ions and lytic enzymes into the ...
9
Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling
... bone surface to study drug-affected cell functional ...number. Bone resorption is a process that osteoclasts degrade bone and subsequently release calcium to blood ...increased bone ...
11
Effect of Bisphosphonate on Osteoclast of Bone
... Ito et al. in 1999 conducted the ultrastructural and cytochemical studies on cell death of osteoclasts induced by bisphosphonate treatment on rat skeleton. Histological, cytochemical and ultrastructural features of ...
7
SYNTHESIS AND CHARACTERIZATION OF SILICA NANOCOMPOSITES FOR BONE APPLICATIONS
... into bone tissues, Quantitating Bone Mineral ...of osteoclast formation, nanoparticle association with Bone surface (Incubation with NP 1/NP 2 for 2 hours in well-plates), statistical ...
5
Prolactin blocks the expression of receptor activator of nuclear factor κB ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis
... Trabecular bone area is reduced and osteoclastogenesis is enhanced in prolactin (PRL)-receptor-null mice subjected to monoarticular adjuvant- induced arthritis ...Bm bone marrow, Ct cortical bone, Tb ...
16
Integrins and Reorganization of Osteoclast Cytoskeleton under Orthodontic Force
... by bone matrix proteins via integrins like integrin αvβ3 which is the most abundant one in osteoclasts [42] and the interaction of integrins with ECM proteins influenced on osteoclasts’ adhesion to the bone ...
8
Osteoclast Response to Bioactive Surface Modification of Hydroxyapatite
... in bone resorp- tion [11]. When initiating bone resorption, osteoclasts become polarized, and three distinct membrane domains appear: a ruffled border, a sealing zone, and a functional secretory domain ...
6
The role of PPARγ in childhood obesity-induced fractures
... of bone remodeling Bone is under strict control of its remodeling, through a delicate and complicated mechanism known as bone coupling which regulates bone turnover of the whole skeleton to ...
11
A short account of metastatic bone disease
... to bone more frequently affect long bones, ribs and vertebrae than other parts of the skeleton, most commonly near the trabecular ...lises bone marrow-derived haematopoietic progenitor cells and endothelial ...
6
Bisphosphonates: mechanisms of action
... the bone mineral, hydroxyapatite ...especially bone. Indeed, they deposit where bone mineral is exposed to the surrounding fluids, thus, especially where bone is formed and ...the bone ...
6
Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption implications for osteoclast quality
... the osteoclast phenotype in response to inhibition of acidification, proteolysis or gen- eral osteoclast ...ganic bone matrix, completely shut down the ability of osteoclasts to resorb bone as ...
13
Water extract of the fruits of Alpinia oxyphylla inhibits osteoclast differentiation and bone loss
... in bone destruc- tion in various bone diseases ...RANKL-induced osteoclast differenti- ation in vitro , we next examined the in vivo effect of WEAO on osteoclast-mediated bone ...
9
Effects of salvianolate on bone metabolism in glucocorticoid-treated lupus-prone B6.MRL-Fas<em><sup>lpr</sup></em>/J mice
... The RANKL and OPG data in this study lend support to the hypothesis that Sal treatment attenuates bone loss in lupus/ GC-treated lupus mice partially through the RANK/RANKL/ OPG system. Third, our current data ...
12
Osteoclast secreted CTHRC1 in the coupling of bone resorption to formation
... cycle, bone for- mation is tightly coupled to the preceding bone resorption carried out by osteoclasts (25, ...that bone resorption triggers formation suggests that certain signals derived from ...
12
IRE1α/XBP1 mediated branch of the unfolded protein response regulates osteoclastogenesis
... in bone marrow cells increases bone mass as the result of defective osteoclastic bone ...In osteoclast precursors, IRE1α was transiently activated during osteoclastogenesis, and suppression of ...
12
Osteoclast independent bone resorption by fibroblast like cells
... calcified bone is linked exclusively to ...demonstrate bone resorption by mononu- clear phagocytes, other observations suggested that tumour-infiltrating macrophages [32], as well as poly- ...
11
Building bone to reverse osteoporosis and repair fractures
... increasing bone mass. Recombinant forms of bone morphogenetic protein 2 (BMP2) and BMP7 are FDA approved to promote spinal fusion and fracture healing, respectively, and the first FDA-approved anabolic drug ...
9
MYC dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα
... during osteoclast differentiation provides metabolites (15–17), although key upstream modulators that induce oxidative metabolic reprogramming in osteoclastogenesis are not yet clari- ...
15
Hypoxic regulation of osteoclast differentiation and bone resorption activity
... Abstract: Bone integrity is maintained throughout life via the homeostatic actions of bone cells, namely, osteoclasts, which resorb bone, and osteoblasts, which produce ...of osteoclast ...
10
Melphalan modifies the bone microenvironment by enhancing osteoclast formation
... for osteoclast gene expression, were also elevated by melphalan treatment, despite other critical RANKL-elicited factors such as NFATc1 being ...drives osteoclast cell fusion, a distinctive feature of ...
12