osteoclast precursor
The effect of bisphosphonate treatment on osteoclast precursor cells in postmenopausal osteoporosis: The TRIO study
... the osteoclast precursor cells as well as the mature osteoclast ...the osteoclast and it may be that high circulating levels of RANKL may lead to increased bone resorption ...of ...
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TNF inhibits production of stromal cell derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood
... Stromal cell-derived factor 1 (SDF-1), a member of the C-X-C chemokine family also known as CXCL12, acts through its receptor CXCR4, and is the master chemokine that modulates trafficking of hematopoietic stem cells and ...
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Prolactin blocks the expression of receptor activator of nuclear factor κB ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis
... increased osteoclast number and bone resorption in the clinic [53, 54] and mice with an osteoblast-specific deletion of Stat3 have an osteope- nic phenotype ...and osteoclast precursor cells to ...
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M CSF mediates TNF induced inflammatory osteolysis
... TNF-α is the dominant cytokine in inflammatory osteolysis. Using mice whose BM stromal cells and osteo- clast precursors are chimeric for the presence of TNF receptors, we found that both cell types mediated the ...
11
LIS1 Regulates Osteoclastogenesis through Modulation of M-SCF and RANKL Signaling Pathways and CDC42
... in osteoclast bone resorption, we have found that LIS1 interacts with PLEKHM1 and regulates microtubule dynamics, dynein function and lysosomal secretion in osteoclasts ...decreased osteoclast formation in ...
12
Erosive arthritis
... mediated osteoclast formation is a key player in structural damage in ...blocked osteoclast formation in inflammatory tissue and prevented the formation of osteoclast precursor cells (Figure ...
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Noncanonical G Protein Dependent Modulation of Osteoclast Differentiation and Bone Resorption Mediated by Pasteurella multocida Toxin
... IMPORTANCE Pasteurella multocida toxin (PMT) induces degradation of nasal turbinate bones, leading to the syndrome of atro- phic rhinitis. Recently, the molecular mechanism and substrate specificity of PMT were ...
9
Stauntonia hexaphylla (Lardizabalaceae) leaf methanol extract inhibits osteoclastogenesis and bone resorption activity via proteasome mediated degradation of c Fos protein and suppression of NFATc1 expression
... the osteoclast precursor ...ited osteoclast differentiation ...on osteoclast differentiation, BMMs were cultured by treatment with ...pressed osteoclast formation were days 0–1 and ...
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(–) Epigallocatechingallate Interferes RANKL/RANK Signal Pathway and Induces Apoptosis during Osteoclastogenesis in RAW264 Cell
... on osteoclast precursor cells was confirmed by Hoechst staining, while the MTT assay revealed that up to 50 µM, EGCG treatment had no ef- fect on cell viability, which might to be explained as the result of ...
10
Signaling crosstalk between RANKL and interferons in osteoclast differentiation
... of osteoclast differentiation is an aspect central to the understanding of the pathogenesis and the treatment of bone diseases such as autoimmune arthritis and ...in osteoclast precursor cells, and ...
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c Fos protein as a target of anti osteoclastogenic action of vitamin D, and synthesis of new analogs
... Biochemical analysis. Serum and urinary calcium concentrations were determined using an autoanalyzer (Hitachi 7170). Urinary deoxypyridino- line was measured with a PYRILINKS-D assay kit (Metra Biosystems Inc.). ...
9
Water extract of the fruits of Alpinia oxyphylla inhibits osteoclast differentiation and bone loss
... The RANKL/RANK pathway is not only crucial for normal bone remodeling but also primarily responsible for pathological bone destruction in various bone dis- eases such as postmenopausal osteoporosis, Paget’s disease, ...
9
Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling
... To investigate the effect of fangchinoline treatment (Figure 1A) on osteoclast formation, BMM cells were incubated with different concentrations of fangchinoline (0.125, 0.25, 0.5, 1 μM) and RANKL (50 ng/ml) for 5 ...
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The Effects of Adiponectin on Bone Metabolism
... Main idea In vivo: ↑ trabecular bone mass ↓ decreased osteoclast number and serum NTx In vitro: ↓ osteoclast differentiation ↑ expression of alkaline phosphatase and mineralization in MC[r] ...
11
Bisphosphonates: mechanisms of action
... in osteoclast number can occur either through direct action on osteoclast precursors, or indirectly by stimulating the osteoblasts to produce an in- hibitor of osteoclast ...formation. ...
6
Physiopathology of osteoclast in bone
... Osteoclasts are the primary therapeutic targets for conditions with excessive bone resorption. Bisphosphonate is a major class of anti-resorptive drug currently available. In the last chapter, this thesis will discuss ...
104
The molecular basis of osteoclast adhesion
... the osteoclast sensing increased extracellular calcium concentrations possibly via an activated calcium -sensing receptor (Ham m erland et ah, 1994; Xia and Ferrier, 1996), and osteoclasts leave the resorption ...
348
Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption implications for osteoclast quality
... the osteoclast phe- notype is important for the control of bone remodeling ...utilized osteoclast inhibitors can therefore be speculated to have different treatment pro- files when used as, for example, ...
13
In vitro and in vivo assays for osteoclast apoptosis
... that osteoclast apoptosis is regulated by ERK activity and Bcl-2 family member ...study osteoclast apoptosis in vitro and in ...on osteoclast survival in ...study osteoclast survival in ...
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THE EFFECT OF CHITOSAN ON OSTEOCLAST VIABILITY, BONE RESORPTION AND RADICAL OXYGEN PRODUCTION OF PRIMARY OSTEOCLAST CULTURE OF MOUSE BONE
... identify osteoclast cells that were formed in mouse bone marrow culture for a duration of 5-8 days, we used TRAP kit as osteoclast cell ...of osteoclast in bone. Protein is released by ...
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