osteoprotegerin ligand/osteoclast differentiation factor
Noncanonical G Protein Dependent Modulation of Osteoclast Differentiation and Bone Resorption Mediated by Pasteurella multocida Toxin
... nuclear factor- B ligand) plays an essential role in ...nuclear factor- B) osteoclast surface receptor and stimulates various signaling ...necrosis factor receptor-associated pro- ...
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Cystatin C as a potential predictor of osteoprotegerin levels in healthy men, a cross sectional, observational study
... serum osteoprotegerin (OPG) and soluble receptor activator of nuclear factor κ B ligand (sRANKL) levels in a randomly selected male cohort over 50 years of age and its association with cystatin C, a ...
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<p>15-Deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> as a potential regulator of bone metabolism via PPARγ-dependent and independent pathways: a review</p>
... B ligand (RANKL) regulates the activity of osteoclasts by binding to receptor activator of NF- κ B (RANK) on its ...54 Osteoprotegerin (OPG) is a decoy receptor for RANKL and belongs to the tumor necrosis ...
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Ebselen Is a Potential Anti-Osteoporosis Agent by Suppressing Receptor Activator of Nuclear Factor Kappa-B Ligand-Induced Osteoclast Differentiation In vitro and Lipopolysaccharide-Induced Inflammatory Bone Destruction In vivo
... nuclear factor kappa-B ligand (RANKL)/osteoprotegerin secreted by ...of osteoclast differentiation inhibited RANKL-dependent osteoclastogenesis by decreasing the phosphorylation of IκB, ...
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Osteoprotegerin: multiple partners for multiple functions.
... Necrosis Factor (TNF)/TNF receptor superfamily is composed by more than 40 members, and controls a lot of genes essential for biological functions such as cellular differentiation, survival and ...family, ...
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Receptor activator of nuclear factor-κB ligand and osteoprotegerin: maintaining the balance to prevent bone loss
... The osteoclast precursor matures into a multinucleated cell under the influence of numerous factors such as cytokines, hormones, and growth ...activated osteoclast in the presence of MCSF and ...the ...
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The Effects of Adiponectin on Bone Metabolism
... ApN regulates bone formation in an autocrine/paracrine manner. ApN and its receptors are expressed in os- teoblastic and osteoclastic cells, indicating participation in bone metabolism not only through an endocrine ...
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Bone regenerative effect of aqueous Cynanchum wilfordii extract in receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation and estrogen deficiency-induced osteoporosis
... mediated osteoporosis in vivo . CWW inhibited RANKL-induced osteoclast formation and tartrate-resistant acid phosphatase (TRAP) activity in primary mouse bone marrow cells. We investigated the osteoprotective ...
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Stauntonia hexaphylla (Lardizabalaceae) leaf methanol extract inhibits osteoclastogenesis and bone resorption activity via proteasome mediated degradation of c Fos protein and suppression of NFATc1 expression
... cells are unable to differentiate into osteoclasts in response to RANKL, and the forced expression of NFATc1 leads to the formation of osteoclasts from BMMs in the absence of RANKL [15]. In our study, S. hexaphylla ...
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Bone loss: Factors that regulate osteoclast differentiation an update
... and osteoprotegerin expression Recent studies have demonstrated that osteotropic factors and hormones such as PTH, 1,25(OH) 2 D 3 , IL-11, IL-1 β , TNF- α or prostaglandin E 2 upregulate RANKL expression in ...
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Licorice isoliquiritigenin-encapsulated mesoporous silica nanoparticles for osteoclast inhibition and bone loss prevention
... superior osteoclast-bioresponsive nanocarriers with good ...RANKL-induced osteoclast formation, decreased the area and quantity of sealing zones, and reduced the osteolytic capacity of osteoclasts in ...
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Therapeutic intervention of inflammatory/immune diseases by inhibition of the fractalkine (CX3CL1)-CX3CR1 pathway
... FKN is a unique chemokine possessing a dual function as a chemoattractant and an adhesion molecule for CX3CR1-expressing monocytes, cytotoxic effector lym- phocytes, and osteoclast precursors. Increasing evidence ...
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Water extract of the fruits of Alpinia oxyphylla inhibits osteoclast differentiation and bone loss
... Previous phytochemical studies have shown that flavo- noids (e.g., tectochrysin and chrysin), diarylheptanoids (e.g., yakuchinone A and yakuchinone B), and sesquiter- penes (e.g., nootkatone) are abundant in ethanol ...
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Expression of osteoprotegerin, receptor activator of nuclear factor kappa-B ligand, tumor necrosis factor-related apoptosis-inducing ligand, stromal cell-derived factor-1 and their receptors in epithelial metastatic breast cancer cell lines
... Finally, despite the advances in knowledge about these molecules, many questions remain unresolved, particu- larly regarding the conflicting roles of OPG in bone me- tastasis and the possible use of OPG as a potential ...
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Signaling crosstalk between RANKL and interferons in osteoclast differentiation
... for osteoclast formation in RANKL-stimulated BMMs, and a very low level of IFN- γ strongly inhibited osteoclast formation even in the presence of an excess amount of ...transcription factor STAT1 ...
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Soluble receptor activator of nuclear factor κB ligand/osteoprotegerin ratio is increased in systemic lupus erythematosus patients
... Introduction: Systemic lupus erythematosus (SLE) patients have lower bone mineral density and increased fracture risk when compared with healthy individuals, due to distinct factors and mechanisms. Bone remodeling is a ...
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Macrophage colony stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors
... that osteoclast progenitors primarily proliferated during the first 4 d, whereas their differentiation into MNCs occurred predominantly during the final 2 d of culture in response to 1 ...of ...
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Metastatic bone disease: Pathogenesis and therapeutic options: Up-date on bone metastasis management.
... Several clinical trials demonstrated that, among N-BPs, zoledronate was the most effective for SRE prevention in both MM and solid tumors, while a significant improvement of survival outcomes was reached only Fig. 4. ...
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Activating transcription factor 4 regulates osteoclast differentiation in mice
... ATF4 is upregulated by M-CSF and PI3K/AKT and is required for M-CSF induction of RANK expression in BMMs. (A and B) Effects of M-CSF on ATF4 in BMMs. Cells were cultured with or without 30 ng/ml M-CSF for the indicated ...
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Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits
... the osteoclast is the exclusive resorptive cell ...of osteoprotegerin/ receptor activator of nuclear factor-κ B/RANK ligand (OPG/RANK/RANKL) has been described as critical in controlling ...
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