Other metal-based photoactivatable anticancer complexes
Photoactivatable platinum (IV) anticancer complexes
... of photoactivatable metal complexes is of crucial interest in the investigation of their ...of complexes 3-6 in water were determined, as described in Chapter 2 (section ...
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Photodecomposition pathways for photoactivatable platinum(IV) diazido anticancer complexes
... platinum complexes synthesised and their cytotoxic ...trans-configured complexes in cis-platin resistant cell lines, suggested that these geometrical isomers induce their cytotoxic effect through a ...
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Photoactivatable metal complexes : from theory to applications in biotechnology and medicine
... are based on some of the presentations at the Royal Society Discussion Meeting in June 2012, many of which are featured in more detail in other articles in this ...as metal–carbonyl complexes ...
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Supramolecular photoactivatable anticancer hydrogels
... A lthough hydrogels are mostly water, they behave like solids due to three-dimensional networks of cross-links within them. Hydrogels often consist of cross-linked polymers and have the properties of colloidal particles. ...
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Metal complexes as potential anticancer agents
... It was realized by Rosenberg that the filamentous growth of bacterial cells under the influence of cisplatin was due to the inhibition of DNA synthesis21. Other fundamental functions of the cell, such as RNA and ...
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Application of analytical techniques for the study of metal based anticancer complexes
... 3.1 Introduction As outlined in Chapter 1, the efficacy of the platinum-‐based anticancer drugs currently in the clinic is attributed to their interactions with DNA. 1,2,3 New generation drugs may also ...
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Synthesis, characterization, photochemistry and anticancer activity of novel photoactivatable platinum(IV) diazidodihydroxido complexes
... 1.3.4 Photoactivatable platinum(IV) anticancer complexes Based on knowledge of the photochemistry of Pt complexes and the idea of PDT, it is possible to design a class of Pt IV ...
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New trends for metal complexes with anticancer activity
... innovative metal-based anticancer ...new complexes that address the downsides associated with cisplatin, especially the systemic toxicity and (acquired) ...or other means, hold the ...
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Unusual DNA binding modes for metal anticancer complexes
... of photoactivatable Pt IV -azide complexes has the potential to avoid the side-effects associated with cisplatin, whilst having the advantage of being ...
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Anticancer activity of various transition metal complexes: a review
... tri-substituted derivatives of the nucleus.Many synthetic methods have been developed and modified to get products of high yield, purity and of desired quality (Bansal lot of drugs like albendazole, mebendazole, ...
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SYNTHESIS AND TESTING OF METAL COMPLEXES OF QUINOXALINE BASED SCHIFF BASES FOR ANTIMICROBIAL AND ANTICANCER ACTIVITIES
... INTRODUCTION: Quinoxalines are a class of fused six-membered nitrogen heterocyclics containing two nitrogens in mutually para dispositions. These compounds have a wide range of applications in pharmacology, bacteriology ...
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Novel perspective of anticancer metal-based drugs: Characteristics of heterometallic complexes and their potential applications
... heterometallic complexes with metal centers that have different coordination geometry, kinetics properties, affinity, and reactivity towards biological relevant ...of metal centers will result in ...
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Synthesis and analysis of pseudo-octahedral metal complexes as anticancer agents
... between based on comparison with analogous inhibitors and the most chemically sound ...pseudo-octahedral complexes provide potentially contentious results due to restricted movement of the ...
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Photoactivatable Ru(II) polypyridyl complexes as antibacterial agents
... of metal complexes has been widely studied for its use in oncology 1- 5 and bacterial ...the anticancer agent cisplatin hydrolyses to provide binding sites available for binding to biomolecules such ...
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Photoactivatable organometallic pyridyl ruthenium(II) arene complexes
... the other complexes so that their generation is ...potential anticancer agents with discriminating preference towards ...pyridine-derivative complexes, studies on CT-DNA interactions in ...
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G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs
... the metal complex scaffold onto one of the terminal ...mode, metal complexes reported in the literature generally present a suitably sized planar surface, which is larger than that involved in DNA ...
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Preparation and Characterization of Thiosemicarbazones Corrosion Inhibition Effect and the Antimicrobial and Anticancer Effect on their Metal Complexes
... Cast iron is widely used for water carrying purposes besides mild steel and other metals. However, the corrosion of cast iron is a serious problem for pipe line industry. In order to minimize corrosion problem, ...
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Photoactivatable cell selective dinuclear trans diazido platinum(IV) anticancer prodrugs
... the other for irradiation ...medium. Complexes were dissolved first in DMSO and then diluted in phenol red-free RPMI-1640 to make the stock solution of the ...all metal complexes used in these ...
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Organometallic iridium anticancer complexes
... platinum-based anticancer drugs, therefore, have stimulated the exploration for other metal-based anticancer complexes (circled metals in Figure ...
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Late transition metal complexes of NHC based macrocycles
... palladium complexes 3 in satisfactory yields, purification on silica was required to remove impurities and the resulting general procedure may not be amenable to the isolation of more reactive, air and ...
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