Ovarian Cancer Metastasis and Epithelial-Mesenchymal Transition
Simulating Pathway-Based Steady States to Prevent Epithelial- Mesenchymal Transition in Ovarian Cancer
... III. Ovarian Cancer Metastasis and Epithelial-Mesenchymal Transition OC is most lethal once it metastasizes to other regions of the body, as surgical treatment of localized ...
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Loss of MKK4 Expression in Ovarian Cancer: A Potential Role for the Epithelial to Mesenchymal Transition
... (mesenchymal epithelial transition) may occur in metastatic ...of ovarian cancer metastasis are ...underlying ovarian cancer metastasis and other mechanisms ...
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MicroRNA-200c overexpression inhibits tumorigenicity and metastasis of CD117+CD44+ ovarian cancer stem cells by regulating epithelial-mesenchymal transition
... Tumor metastasis has been considered the main cause of death in patients of various malignant ...the epithelial- mesenchymal transition (EMT) that impacts cell differentiation and tumor ...
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CD133 ovarian cancer stem-like cells promote non-stem cancer cell metastasis via CCL5 induced epithelial-mesenchymal transition
... breast cancer, non- stem cancer cells can dedifferentiate to gain stem cell- like properties, both spontaneously in vitro and in a mixed xenograft with CSCs in vivo ...non-stem cancer cells makes it ...
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RASAL2 down-regulation in ovarian cancer promotes epithelial- mesenchymal transition and metastasis
... ABSTRACT Ovarian cancer is the most lethal gynecologic malignancy, and transcoelomic metastasis is responsible for the greatest disease ...breast cancer. In this study, we identified RASAL2 as ...
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Molecular profiling supports the role of epithelial-to-mesenchymal transition (EMT) in ovarian cancer metastasis
... 2-fold difference in expression in the Group 1 metastatic samples. In addition, a number of the differences in ex- pression are consistent with the hypothesis that, on the molecular level, Group 2 metastatic samples are ...
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Targeting epithelial-mesenchymal transition and cancer stem cells for chemoresistant ovarian cancer
... recurrent ovarian cancer therapy and responsible for treatment failure and unfavorable clinical ...in ovarian cancer would help to predict disease progression, develop new therapies and ...
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Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis
... the mesenchymal phenotype and cancer cell ...lets cancer cells compromise the intrinsic functions of a MET inducer for primary tumor escape and metastatic ...
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MicroRNA-216a promotes the metastasis and epithelial–mesenchymal transition of ovarian cancer by suppressing the PTEN/AKT pathway
... PTEN, which is a well-known tumor suppressor, has been found to play an important role in the development and progression of various human cancers. 22–24 This study demonstrated that miR-216a could directly modulate the ...
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Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk
... state cancer registries of AL, AZ, AR, CA, CO, CT, DE, FL, GA, HI, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, and WYL (NHS); ...
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MMP-14 and CD44 in Epithelial-to-Mesenchymal Transition (EMT) in ovarian cancer
... The lack of significance of EMT for prognosis in ovarian cancer evident in the present study may also be due to the cross-sectional study design, in which the tumors were not followed in time. If a subset ...
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EZH2 inhibition promotes epithelial-to-mesenchymal transition in ovarian cancer cells
... the epithelial characteristics of cancer cells and that erasure of the H3K27me3 marks catalyzed by EZH2 permits transition to a mesenchymal ...the mesenchymal phenotype induced by ...an ...
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miR-573 inhibits prostate cancer metastasis by regulating epithelial- mesenchymal transition
... PCa metastasis involves miR-573, we transfected VCaP-GATA3 cells with miR-573 ...breast cancer [24], ectopic expression of GATA3 could also inhibit TGF-β1-induced EMT in 22RV1, as evident by increased ...
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Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer.
... cytomorphological transition from round to spindle shape that is highly associated with the acquisition of cell motility resembles the phenomenon of so-called epithelial-to- mesenchymal ...
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TRAP1 downregulation in human ovarian cancer enhances invasion and epithelial-mesenchymal transition
... Ovarian cancer (OC) is the second leading cause of gynecological cancer death ...and epithelial–mesenchymal transition ...the epithelial marker E-Cadherin, whereas it ...
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Role and prognostic significance of the epithelial-mesenchymal transition factor ZEB2 in ovarian cancer
... in ovarian cancer, as shown by ZEB2 ...Hey ovarian cell line, HuR silencing decreased ZEB2 and ZEB1 nuclear expression and impaired ...in ovarian cancers revealed that nuclear ZEB2 is ...
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Epithelial to mesenchymal transition and breast cancer
... the transition from the epithelial to mesenchymal phenotype, and the reverse ...normal-like epithelial cells undergoing ...the mesenchymal phenotype in primary tumors and metastases may ...
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Downregulated lincRNA HOTAIR expression in ovarian cancer stem cells decreases its tumorgeniesis and metastasis by inhibiting epithelial-mesenchymal transition
... and metastasis but a link between the high expression of HOTAIR and the metastatic cascade of cancer stem cells (CSCs) needs to be further ...and metastasis of epithelial ovarian ...
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FOXF2 deficiency promotes epithelial mesenchymal transition and metastasis of basal like breast cancer
... that mesenchymal FOXF2 might be induced expression in luminal cells that had undergone transdifferentiation into basal-like cells, and when FOXF2 depletion during the progression of the cells adapted ...
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Withania somnifera Root Extract Inhibits Mammary Cancer Metastasis and Epithelial to Mesenchymal Transition
... of cancer patient death; therefore, there is a need to develop anti-metastatic therapies that can be administered over long durations to specifically inhibit the motility of cancer ...the epithelial ...
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