overall survival (OS)
Progression-free survival as a surrogate endpoint for overall survival in patients with third-line or later-line chemotherapy for advanced gastric cancer
... Our results suggest that PFS may serve as an intermediate endpoint for OS. However, this analysis had some unavoidable limitations. It is worth noting that patients enrolled in these stud- ies were required to meet the ...
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Progression-free survival as a surrogate endpoint of overall survival in patients with metastatic colorectal cancer
... These therapeutic regimens showed a statistically signifi- cant impact on overall survival (OS). To assess the efficacy of this anticancer treatment in clinical trials, the often used surrogate endpoint has ...
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HER3 over-expression and overall survival in gastrointestinal cancers
... and overall survival (OS) in gastrointestinal cancers have yielded conflicting ...association. Overall, we observed that HER3 over-expression was associated with worse OS at five years (OR = ...worse ...
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<p>Nomograms for predicting overall survival and cancer-specific survival in patients with surgically resected intrahepatic cholangiocarcinoma</p>
... Additionally, many ICC patients aged over 60 have high rates of comorbidities and tend to suffer from competing events, ie, death from non-cancer speci fi c diseases. 10 The risk of competing events increases as the age ...
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Interpreting overall survival results when progression-free survival benefits exist in today's oncology landscape: a metastatic renal cell carcinoma case study
... progression-free survival (PFS) as an intermediate endpoint to overall survival (OS) has grown in recent years, due to the challenges in demonstrating an OS benefit within clinical trials ...where ...
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Challenges and methodologies in using progression free survival as a surrogate for overall survival In oncology
... Outcomes from clinical and other healthcare trials of most interest to patients and health systems are usually increases in the length and quality of life as a result of treatment. This poses a problem, because to ...
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Long-term overall survival and prognostic score predicting survival: the IMPACT study in precision medicine
... in overall survival (OS) of patients with newly diagnosed Bcr-Abl-positive chronic myeloid leukemia (CML) treated with imatinib (a potent inhibitor of the aberrant Bcr-Abl tyrosine kin- ase) exemplified the ...
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Nomograms to predict overall survival and cancer-specific survival in patients with adrenocortical carcinoma
... Purpose: To develop nomogram models to predict individualized estimates of overall survival (OS) and cancer-specific survival (CSS) in patients with adrenocortical carcinoma (ACC). Patients and ...
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Overall survival and disease-free survival in endometrial cancer: prognostic factors in 276 patients
... increased overall survival and recurrence-free survival for patients with adenocarcinoma or adenoacanthoma as compared to other tumor types (papil- lary, clear-cell carcinoma, and ...disease-free ...
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Incidence and overall survival of malignant ameloblastoma
... the overall incidence rate of malignant ameloblastoma was ...of overall survival related to this tumor ...relative survival as used elsewhere ...
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Overall Survival with Palbociclib and Fulvestrant in Advanced Breast Cancer.
... regarding overall survival from phase 3 trials of letrozole and CDK4/6 inhibitors are ...of overall survival than for the statistical analysis of progression-free surviv- al, and therefore the ...
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MicroRNA-21 expression is associated with overall survival in patients with glioma
... We investigated miR-21 expression in glioma and deter- mined if this marker could predict disease relapse and pa- tient outcomes. We observed that increased miR-21 expression was evident in human glioma tissues compared ...
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Polymorphism in asparagine synthetase is associated with overall survival of hepatocellular carcinoma patients
... between overall survival and demographic characteristics, and rs1049674 and rs34050735 were estimated using the Kaplan–Meier ...A survival curve was drawn with the Kaplan– Meier method for each ...
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Original Article PI3K expression predicts overall survival in lung adenocarcinoma
... progression [8]. In the present study, both PI3K and p-PI3K expression were explored in 118 NSCLC tissue samples and 13 adjacent nor- mal pulmonary tissue specimens. In NSCLC tis- sue samples, the positive rates of PI3K ...
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Impact of molecular profiling on overall survival of patients with advanced ovarian cancer
... In any prospective observational study, there can be significant sources of bias that diminish the strength of the conclusions obtained from the data. This study is no different, in that even though the cohorts were well ...
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Radiofrequency Ablation of hepatocellular carcinoma: a meta-analysis of overall survival and recurrence-free survival
... resection have a comparable impact on overall (OS) and recurrence-free survival (RFS). Given the different therapeutic options that occur in patients with HCC in the initial stage, it is absolutely ...
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The radiosensitivity index predicts for overall survival in glioblastoma
... OS was defined as time from pathological diagnosis, last follow-up, or death. Fisher’s exact test with Monte Carlo simulation was used to study association between radiosensitive and radioresistant variables and other ...
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Progression-free survival as a potential surrogate for overall survival in metastatic breast cancer
... In the present study, a correlation analysis between PFS/TTP and OS was first performed to determine if these measures could be considered as valid surrogate endpoints for OS. For this analysis, each treatment arm ...
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A nomogram to predict overall survival for biliary tract cancer
... Patients and methods: Patients diagnosed with BTC between 2004 and 2014 were selected for the study from the Surveillance, Epidemiology, and End Results (SEER) database. All patients were randomly allocated to 2 sets, ...
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Methylation and expression of PTPN22 in esophageal squamous cell carcinoma
... progression. Overall survival (OS) was calculated from the date of surgery to the date of death or last contact on or before June ...Progression-free survival (PFS) was calculated from the date of ...
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