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An integrated safety analysis of combined acetaminophen and ibuprofen (Maxigesic®/ Combogesic®) in adults

<p>An integrated safety analysis of combined acetaminophen and ibuprofen (Maxigesic<sup>&reg;</sup>/ Combogesic<sup>&reg;</sup>) in adults</p>

... Analysis of the safety data pooled from multiple repeated- dose Phase II/III clinical studies illustrates the excellent tolerability and safety of multiple FDC APAP/IBP oral tablet dos[r] ...

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Calibrated measurement of acuity, color and stereopsis on a Nintendo&reg; 3DS&trade; game console

<p>Calibrated measurement of acuity, color and stereopsis on a Nintendo<sup>&reg;</sup> 3DS&trade; game console</p>

... A new game for the autostereoscopic screen on the Nintendo 3DS provided results that correlated well with conventional clinical tests of monocular near visual acuity, stereopsis and red [r] ...

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Pretreatment detection of circulating and tissue CD133+&nbsp;CD44+ cancer stem cells as a prognostic factor affecting the outcomes in Egyptian patients with colorectal cancer

<p>Pretreatment detection of circulating and tissue CD133<sup>+&nbsp;</sup>CD44<sup>+</sup> cancer stem cells as a prognostic factor affecting the outcomes in Egyptian patients with colorectal cancer</p>

... Descriptive data in the form of mean, median, range, SD, and percentages were used. Mann–Whitney U-test was used to find a relation between two groups of ordinal variables, chi-squared test between ≥ 2 groups of ...

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Assessment of Acceptability and Ease of Use of Haemoglobin Spray (Granulox&reg;) in the Management of Chronic Wounds

<p>Assessment of Acceptability and Ease of Use of Haemoglobin Spray (Granulox<sup>&reg;</sup>) in the Management of Chronic Wounds</p>

... One retrospective, controlled, prospective cohort study eval- uated the use of the haemoglobin spray-on diabetic foot ulcers (DFU). 7,37 These patients have a greater than two-fold increase in mortality compared with ...

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BetaEval Global: Prospective, Multinational, Observational Cohort Study of Patients Using BETACONNECT&reg;

<p>BetaEval Global: Prospective, Multinational, Observational Cohort Study of Patients Using BETACONNECT<sup>&reg;</sup></p>

... Conclusion: Overall, the results from BetaEval Global demonstrated that in this cohort of patients with RRMS or CIS on interferon beta-1b, use of the BETACONNECT autoinjector was associa[r] ...

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PD-L1 in Lung Adenocarcinoma: Insights into the Role of 18F-FDG PET/CT

<p>PD-L1 in Lung Adenocarcinoma: Insights into the Role of <sup>18</sup>F-FDG PET/CT</p>

... The association between two continuous variables was analyzed by Mann – Whitney U-test or t-test. The associa- tion between two categorical variables was evaluated by chi-square test. The Spearman correlation analysis ...

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Comparing radiopaque markers and 13C-labelled breath test in diabetic gastroparesis diagnostics

<p>Comparing radiopaque markers and <sup>13</sup>C-labelled breath test in diabetic gastroparesis diagnostics</p>

... radiographer to produce pictures of suf fi cient quality. Our experience was that image quality sometimes was below the desired levels. This may have several explanations, such as different radiographers performing the ...

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Cost-effectiveness of adding Endocuff&reg; to standard colonoscopies for interval colorectal cancer screening

<p>Cost-effectiveness of adding Endocuff<sup>&reg;</sup> to standard colonoscopies for interval colorectal cancer screening</p>

... Conclusion: Endocuff ® for screening colonoscopies was expected to reduce interval CRC incidence and death, improve QoL, and be cost-effective to the device purchaser and cost- saving to[r] ...

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A Synthetic Peptide 2Abz23S29 Reduces Bacterial Titer and Induces Pro-Inflammatory Cytokines in a Murine Model of Urinary Tract Infection

<p>A Synthetic Peptide 2Abz<sup>23</sup>S<sup>29</sup> Reduces Bacterial Titer and Induces Pro-Inflammatory Cytokines in a Murine Model of Urinary Tract Infection</p>

... In sup- port of this, Miles et al reported that systemic administra- tion of HNP-1 protects peritonitis mice and plays a translation-based anti-in fl ammatory role in ...

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TearCare&reg; system extension study: evaluation of the safety, effectiveness, and durability through 12 months of a second TearCare&reg; treatment on subjects with dry eye disease

<p>TearCare<sup>&reg;</sup> system extension study: evaluation of the safety, effectiveness, and durability through 12 months of a second TearCare<sup>&reg;</sup> treatment on subjects with dry eye disease</p>

... the P-values were the result of separate tests of whether the mean difference = 0 for each follow-up time ...the P-values were from simple mixed-effects linear models (with no covariates) that allow for ...

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P53 Mutant p53N236S Regulates Cancer-Associated Fibroblasts Properties Through Stat3 Pathway

<p>P53 Mutant p53<sup>N236S</sup> Regulates Cancer-Associated Fibroblasts Properties Through Stat3 Pathway</p>

... Our previous study showed that p53 S/S mice manifested to an early onset of sarcomas that metastasized to various organs, such as liver and lung. 15 We attempted to under- stand the phenotypes resulting from the p53S ...

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RNA m6A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway

<p>RNA m<sup>6</sup>A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway</p>

... Figure 4 Effects of METTL3 depletion on SHH-GLI pathway and apoptosis. (A)The protein level of SHH-GLI pathway was analyzed by Western blotting after METTL3 depletion. (B, C) The mRNA level of c-Myc and cycling D1 was ...

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Combined Therapeutic Effects of 131I-Labeled and 5Fu-Loaded Multifunctional Nanoparticles in Colorectal Cancer

<p>Combined Therapeutic Effects of <sup>131</sup>I-Labeled and 5Fu-Loaded Multifunctional Nanoparticles in Colorectal Cancer</p>

... tumor growth slightly compared with saline or blank Cet-PEG -PLA treatment (Figures 6A and B). Moreover, the combina- tion treatment of Cet-PEG-PLA-5Fu- 131 I markedly sup- pressed tumor growth, revealing the ...

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Improving fluid resuscitation in pediatric shock with LifeFlow&reg;: a retrospective case series and review of the literature

<p>Improving fluid resuscitation in pediatric shock with LifeFlow<sup>&reg;</sup>: a retrospective case series and review of the literature</p>

... The Pediatric Advanced Life Support (PALS) Provider Manual speci fi cally calls for a 20 mL/kg fl uid bolus to be given over 5 mins for severe shock with hypovolemia or hypotension, noting[r] ...

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XEN&reg; Gel Stent: A Comprehensive Review on Its Use as a Treatment Option for Refractory Glaucoma

<p>XEN<sup>&reg;</sup> Gel Stent: A Comprehensive Review on Its Use as a Treatment Option for Refractory Glaucoma</p>

... A prospective multicenter nonrandomized trial by Reitsamer et al 32 compared results of Xen 45 solo (n=120) and Xen 45 combo (n=98) with 2-year follow-up in uncon- trolled moderate POAG. Two-hundred and forty eyes of 218 ...

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Daily consumption of the collagen supplement Pure Gold Collagen&reg; reduces visible signs of aging

<p>Daily consumption of the collagen supplement Pure Gold Collagen<sup>&reg;</sup> reduces visible signs of aging</p>

... The results of this study show that daily oral consumption of Pure Gold Collagen supplement does lead to a detectable improvement in skin collagen density over a 12-week peri[r] ...

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Remicade&reg;&nbsp;(infliximab):&nbsp;20 years of contributions to science and medicine

<p>Remicade<sup>&reg;</sup>&nbsp;(infliximab):&nbsp;20 years of contributions to science and medicine</p>

... Thus, the phase II/III program had answered all three initial questions about long-term TNF blockade with Remicade: 1) mAbs could be administered repeatedly as maintenance therapy, and s[r] ...

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IN.PACTTM AdmiralTM drug-coated balloons in peripheral artery disease: current perspectives

<p>IN.PACT<sup>TM</sup> Admiral<sup>TM</sup> drug-coated balloons in peripheral artery disease: current perspectives</p>

... DEEP trial, a total of 358 patients mostly with CLI were randomized to IN.PACT Amphirion DCB treatment group or BA treatment group. Coprimary efficacy outcomes were TLR and angiographic LLL at 12 months, and the primary ...

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ClariVein&reg;, mechanochemical endovenous ablation: patient selection and perspective

<p>ClariVein<sup>&reg;</sup>, mechanochemical endovenous ablation: patient selection and perspective</p>

... A second clinical study was conducted in the Netherlands to assess the clinical ef fi cacy of this device with 30 GSVs in 25 patients using POL (Aethoxysklerol, Kreussler Pharma, Wiesbaden, Germany) at two hospitals. The ...

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Optimization of the Oertli CataRhex 3&reg; phacoemulsification machine

<p>Optimization of the Oertli CataRhex 3<sup>&reg;</sup> phacoemulsification machine</p>

... microchatter or bounce around the tip for several seconds before a proper vacuum seal is established to allow prompt emulsification. New mean values and SDs were thus recalculated to reduce noise in the data. For vacuum ...

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