p53 and c-myc
The Relationship between Mouth Squamous Cell Carcinoma (MSCC) with HPV Infection and the Presence of p53 & c myc Mutation
... amplify p53 and c-myc gene and continued Single Strand Conformational Polymorphism (SSCP) analysis and followed with meas- urement using densitometer to see mutation ...of p53 and ...
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CELLFOOD™ induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways
... between p53, c-myc, Bcl-2, p21, p27 and PI3K/Akt pathway and CF-induced apoptosis in MSTO-211 and HCT-116 cells, which may improve prevention outcomes for meso- thelioma and colon ...of p53, ...
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Mantle cell lymphoma-like lymphomas in c- myc -3’RR/p53 mice and c- myc -3’RR/Cdk4 R24C mice: differential oncogenic mechanisms but similar cellular origin
... stimulation by pristine, a pro-inflammatory tumor promoter [2]. Interleukin 14 alpha (IL-14α)/c-myc double transgenic mice developed lymphomas reproducing many features of blastoid variant of MCL [3]. ...
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PubMedCentral-PMC4728445.pdf
... the p53 and c-Myc expression was affected when DCAF1 was acutely ...that p53 protein level greatly elevated at the time of DCAF1 deletion ...of p53 target genes p21 and Bax (Fig. 7d), ...
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Daily rhythm variations of the clock gene <em>PER1</em> and cancer-related genes during various stages of carcinogenesis in a golden hamster model of buccal mucosa carcinoma
... of P53 mRNA expres- sion typically decreased gradually, indicating a weakened effect on cancer inhibition and apoptotic ...and C-MYC mRNA expression increased gradually, result- ing in enhanced ...
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Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics
... 2; P53: tumor protein p53; Bcl-2: B-cell lymphoma 2; SMAD: dro- sophila mothers against decapentaplegic; ATM: ataxia telangiectasia mutated; MutLα: MLH1-PMS2 hetero- dimer; BRCAl: breast cancer 1; NMR: ...
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Targeting the Seven Cancer Hallmarks by Modulation of Oxidative Stress induced Inflammation and Immune Activation: A Radical Therapeutic Approach
... (Ras, c-Myc), tumour suppressor genes (p53, RB), hypoxia-associated transcription, growth factors (HIF-1, TF, VEGF) [111], MHC molecules, downregulation of adhesive molecules, growth factors and ...
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The role of c-Myc-RBM38 loop in the growth suppression in breast cancer
... process. c-Myc acts as an oncogenic transcription factor that promotes G1-phase cell cycle progression by increasing the activity of cyclin-dependent protein kinases 2, 4 and 6 ...which c-Myc ...
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Therapeutic dosages of aspirin counteract the IL-6 induced pro-tumorigenic effects by slowing down the ribosome biogenesis rate
... that p53 down-regulation led to the acquisition of cellular phenotypic changes which are characteristic of epithelial- mesenchymal transition (EMT) ...[22]. P53 down-regulation was due to IL-6-dependent ...
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SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B
... and c-Myc, together with p53 mutation, have been confirmed as biomarkers that gov- ern the response to aurora kinase inhibitors [49, ...mutant p53 are more sensitive to treatment with aurora ...
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The anomalous expressions of hif, myc, and p53 in metabolic reorganization with therapeutic approaches
... (v-myc). MYC in the mammalian cell occurs in three distinct forms C- myc, N-myc, L-myc each of them arises from different gene families having similarities in function but differ ...
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p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia
... humans, MYC oncogene is frequently overexpressed in Burkitt’s, T-cell, and B-cell ...or p53 expression in lymphomas has been associated with poor ...or p53 on the ability of MYC inactivation ...
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Brief inactivation of c Myc is not sufficient for sustained regression of c Myc induced tumours of pancreatic islets and skin epidermis
... of c- Myc [9], invasive β-cell tumours only originate once apop- tosis is prevented, in this case by constitutive over-expres- sion of the protein Bclx L ...upon c-Myc activation, rendering ...
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Invasion of Host Cells by JC Virus Identifies a Novel Role for Caveolae in Endosomal Sorting of Noncaveolar Ligands
... dosomes. A Rab5 dominant defective mutant (Rab5-S34N) was the only dominant defective Rab-GTPase mutant tested that reduced JCV infection. These data are consistent with our earlier work showing that JCV entry and ...
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Original Article Expression of c-Myc and Fas correlates with perineural invasion of pancreatic cancer
... of c-Myc in pancreatic tumor tissue may give rise to a high rate of LNM and PNI or ...of c-Myc was higher in cancer tissues than paracancerous tissues, and cytoplasm ex- pression of ...
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Addiction to Runx1 is partially attenuated by loss of p53 in the Eµ-Myc lymphoma model
... against Myc- driven induction of p53 and/or downstream responses, and becomes superfluous after loss of the intact Tp53 allele during in vitro ...temperature-sensitive p53 expression construct ...
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p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance.
... specific upregulation of the pro-apoptotic gene Bbc3 (Puma), but not the pro-apoptotic genes Pmaip1 (Noxa) or Bax (Fig. S1C, D). Both the cyclin-dependent kinase inhibitor p21 and Puma are well-characterized effectors of ...
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Mitochondrial Alteration: A Major Player in Carcinogenesis
... [62]. MYC is also one of the important transcription factors which up regulates several key enzymes involved glycolysis and TCA cycle, and increases mitochondrial OXPHOS and biogenesis [63, ...inhibit MYC ...
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CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC
... Cells were lysed in lysis buffer, and protein concentra- tions were measured with the BCA protein assay kit (ThermoFisher). Proteins were separated by 10% SDS- PAGE and transferred electrophoreticly onto polyvi- nylidene ...
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The Notch target gene hairy2a impedes the involution of notochordal cells by promoting floor plate fates in Xenopus embryos
... The c-myc epitope harboured by the notch ICD or su(H) DBM constructs used for mRNAs injections and the fluorescein tag of AMOh were detected by immunohistochemistry. For this purpose, after in situ ...
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