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p53 gain-of-function

An inducible mouse model for skin cancer reveals distinct roles for gain  and loss of function p53 mutations

An inducible mouse model for skin cancer reveals distinct roles for gain and loss of function p53 mutations

... of p53, which may exhibit gain-of-function ...acquiring p53 gain-of-function versus loss-of-function mutations is critical for the generation of effective therapies for ...

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The Gain of Function of p53 Mutant p53S in Promoting Tumorigenesis by Cross-talking with H-RasV12

The Gain of Function of p53 Mutant p53S in Promoting Tumorigenesis by Cross-talking with H-RasV12

... type p53 (Ab1) or p53S (Ab1 recognizing p53S and anti-cMyc recogniz- ing Myc tag) were added to the EMSA reaction to perform super-shift ...the function of regulating its down stream ...

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Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63.

Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63.

... the p53/p63 logo is also obvious, both in Pscan and de novo motif discovery; the precision of the ChIP-Seq technique allows us to conclude that the two TFs, which are bound within 50 bp, share the same DNA ...wt ...

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Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression

Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression

... Cells were homogenized in a lysis buffer composed by 50 mM Hepes pH 7.5, 5 mM EDTA pH 8.0, 10 mM MgCl2, 150 mM NaCl, 50 mM NaF, 20 mM β-glicerophosphate, 0.5% NP40, 0.1 mM sodium orthovanadate, 1 mM PMSF, 1 mM DTT and ...

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Suppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo

Suppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo

... mutant p53 protein. The growth of tumors bearing p53 mutations was also inhibited by treatment with these two reagents in vitro and in vivo through multiple mechanisms, implying that mutant p53 ...

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Characterization of a new mouse p53 variant: loss-of-function and gain-of-function

Characterization of a new mouse p53 variant: loss-of-function and gain-of-function

... reported p53 variant was not able to regu- late p21 or other target genes because of the loss of its transactivation ...wild-type p53 for a dominant-negative ...new p53 variant could suppress the ...

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Overcoming the Dominant Negative Effect of Mutant p53+/R172H Mice.

Overcoming the Dominant Negative Effect of Mutant p53+/R172H Mice.

... Mutant p53 proteins accumulate in tumors, function as dominant negative inhibitors to block wild type p53 activity and some mutant p53 proteins display gain-of-function ...

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Novel Combinatorial Therapeutic Strategy to Overcome Gain-of-Function p53 Mutations

Novel Combinatorial Therapeutic Strategy to Overcome Gain-of-Function p53 Mutations

... results using cells expressing the R175H (Hec50 endometrial cancer cells) and R248Q (OVCAR3. 256[r] ...

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Original Article Sema3F downregulates p53 expression leading to axonal growth cone collapse in primary hippocampal neurons

Original Article Sema3F downregulates p53 expression leading to axonal growth cone collapse in primary hippocampal neurons

... The lentivirus used for expression of green fluo- rescent protein (GFP) and GFP-p53 were obtained from Sunbio (Shanghai, China). For transfection, the lentivirus was mixed with rat hippocampal neurons in 2% B27 ...

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A role for p53 in terminal epithelial cell differentiation

A role for p53 in terminal epithelial cell differentiation

... for p53 in devel- opment and differentiation. For example, p53-induced differentiation is well documented in a number of cell lineages such as myogenic cells, osteogenic cells, ker- atinocytes, neurons, and ...

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Risks and Benefits of Gain of Function Experiments with Pathogens of Pandemic Potential, Such as Influenza Virus: a Call for a Science Based Discussion

Risks and Benefits of Gain of Function Experiments with Pathogens of Pandemic Potential, Such as Influenza Virus: a Call for a Science Based Discussion

... of function,” or ...new function, such as mammalian transmissibility, increased virulence for hu- mans, or evasion of existing host ...not gain of function per se but rather the selection of ...

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Influenza Gain of Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness

Influenza Gain of Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness

... Influenza Gain of Function Experiments Their Role in Vaccine Virus Recommendation and Pandemic Preparedness Influenza Gain of Function Experiments Their Role in Vaccine Virus Recommendation and Pandem[.] ...

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Seizure Suppression by Gain-of-Function escargot Mutations

Seizure Suppression by Gain-of-Function escargot Mutations

... fertility, and shortened life span (D. Kuebler and M. well as the UAS-esg insertion, show similar ectopic expres- Tanouye, unpublished results). These side effects ob- sion patterns under elav-GAL4 control and thereby ...

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The K-bZIP Protein from Kaposi's Sarcoma-Associated Herpesvirus Interacts with p53 and Represses Its Transcriptional Activity

The K-bZIP Protein from Kaposi's Sarcoma-Associated Herpesvirus Interacts with p53 and Represses Its Transcriptional Activity

... various p53 subse- quences were generated from full-length p53 cDNA (a gift from ...PCR-amplified p53 cDNA was cleaved with BamHI and XhoI and inserted into hemagglutinin (HA)- tagged pcDNA3 and ...

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The Effect of Wild Type P53 Gene Transfer on Growth Properties and Tumorigenicity of PANC-1 Tumor Cell Line

The Effect of Wild Type P53 Gene Transfer on Growth Properties and Tumorigenicity of PANC-1 Tumor Cell Line

... he p53 tumor suppressor gene is the most common known mutated sequence in human cancers, 50% of all human cancers lacks a wild type (wt) p53 gene allele and thus generates a functionally defective ...

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Glial and Neuronal Functions of the Drosophila Homolog of the Human SWI/SNF Gene ATR-X (DATR-X) and the jing Zinc-Finger Gene Specify the Lateral Positioning of Longitudinal Glia and Axons

Glial and Neuronal Functions of the Drosophila Homolog of the Human SWI/SNF Gene ATR-X (DATR-X) and the jing Zinc-Finger Gene Specify the Lateral Positioning of Longitudinal Glia and Axons

... To explore the transcriptional mechanisms control- ling axon patterning, we investigated the cell-specific roles of jing and DATR-X in regulating axon formation in the embryonic CNS. The roles of DATR-X and jing in the ...

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Leukemia associated NOTCH1 alleles are weak tumor initiators but accelerate K ras–initiated leukemia

Leukemia associated NOTCH1 alleles are weak tumor initiators but accelerate K ras–initiated leukemia

... although gain-of-function alleles that initiated only weak downstream signals also induced ectopic T cell development, these more common alleles failed to efficiently initiate leukemia ...weak ...

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EDFA WDM Optical Network using GFF

EDFA WDM Optical Network using GFF

... signal gain can be improved by more than 5 dB with the use the double pass ...high gain and narrow ASE ...and gain. This paper [7] presents amplifier’s gain and noise power which appear in the ...

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RBM38 plays a tumor-suppressor role via stabilizing the p53-mdm2 loop function in hepatocellular carcinoma

RBM38 plays a tumor-suppressor role via stabilizing the p53-mdm2 loop function in hepatocellular carcinoma

... (wt) p53 in liver cancer cells and HCC tissues compared to the corresponding normal liver cells and adjacent liver ...the p53-mdm2 loop and promote HCC, even though p53 and mdm2 transcript amounts ...

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A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells

... anti- p53 (FL393) and polyclonal anti-Bax (all from Santa Cruz Biotechnology), purified mouse anti-phospho-Histone H2AX (Ser139) (Millipore, clone JBW301; kindly provided by ...

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