p53 transcriptional activity
The Human Papillomavirus E6 PDZ Binding Motif Links DNA Damage Response Signaling to E6 Inhibition of p53 Transcriptional Activity
... on p53 transcriptional transactivation on a variety of different promoters—PUMA, p21, Mdm2, and BAX— using Renilla luciferase as a transfection efficiency ...of p53 through the ubiquitin proteasome ...
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Overcoming the Dominant Negative Effect of Mutant p53+/R172H Mice.
... the p53 N-terminus TAD domain and inhibit its transactivation ...the p53 transcriptional activity, not its stability ...ubiquitinating p53 [128, 148]. This Mdm2-Mdmx heterodimer ...
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Survival in males with glioma and gastric adenocarcinoma correlates with mutant p53 residual transcriptional activity
... of p53 functional loss in glioma and gastric cancer ...mutant p53 functional gradient effect, a term used to describe the functional diversity observed among different mutants, is clearly demonstrated by ...
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Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor
... of p53 between the senescence and quiescence program in the p53-arrested cells [76, ...the p53-induced quiescence is in fact a result of suppression of senescence by ...of p53 converted ...
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A Functional Complex of Adenovirus Proteins E1B-55kDa and E4orf6 Is Necessary To Modulate the Expression Level of p53 but Not Its Transcriptional Activity
... of p53’s expression level but not transcriptional inhibition requires a functional complex of E4orf6 and ...of p53 transcriptional activity in the presence of E1B-55kDa and E4orf6 ...
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The Human Papillomavirus Type 16 E6 Oncoprotein Can Down-Regulate p53 Activity by Targeting the Transcriptional Coactivator CBP/p300
... of p53 transcriptional activity by 16E6 cor- relates with CBP binding and not p53 ...down-regulate p53-dependent transcription. U2-OS cells were transfected with the ...
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The p53 transcriptional pathway is preserved in ATM mutated and NOTCH1 mutated chronic lymphocytic leukemias
... the p53 transcriptional activity while mutations of other hot spots abrogated p53 transcriptional activity, as also reported by other studies ...inherited p53 mutations ...
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DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53
... suppressor, p53, which is mutated in almost 50% of tumors [19], plays an important role in oncogenic signaling ...and p53 in NSCLC, which may provide valuable insights into the regulatory mechanism of lung ...
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PES1 promotes breast cancer by differentially regulating ERα and ERβ
... the transcriptional activity of ERα while inhibiting transcriptional activity of ...ERβ transcriptional activity, PES1 increased the stability of the ERα protein and decreased ...
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p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways
... Along with its pro-tumorigenic effects, inflammation also induces the host anti-tumor immune response and can be used in cancer immunotherapy [42]. Since inflammation-related genes are enriched among Synergistic Targets ...
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The role of YY1 in reduced HP1α gene expression in invasive human breast cancer cells
... regulates p53 by facilitating its interaction with Mdm2 (and its human ortho- logue, Hdm2), leading to p53 ubiquitination ...through p53-independent pathways ...
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Dissection of the functional interaction between p53 and the embryonic proto oncoprotein PAX3
... repress p53-dependent transcription ...repress p53-dependent transcription is dependent upon the ability of both its paired- and homeo- domains to bind DNA (shown by N47H and WS265 mutants respectively), as ...
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p53 in the mitochondria, as a trans-acting protein, provides error-correction activities during the incorporation of non- canonical dUTP into DNA
... of p53 translocation to mitochondria substantially reduced nutlin-induced apoptosis ...of p53 in DNA repair program during the incorporation of dU into ...of p53 in mitochondria (Figure 7A), in ...
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Impact of the Adenoviral E4 Orf3 Protein on the Activity and Posttranslational Modification of p53
... human p53 (81), we have extended proteomic analyses of modifications to the p53 population that accumulates in normal human fibroblasts infected by an adenovirus mutant that can di- rect synthesis of ...
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S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease
... a transcriptional repressor of the tumor suppressor gene p53 ...represses p53 promoter activity in cells expressing parkin either transiently or ...of p53, presenilin 1 and presenilin ...
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EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer
... These new data indicate that structural changes to the core bisphenol of EPI-001 as well as the covalent warhead may be required to mitigate the AR- independent effects reported in this study and in the toxicology ...
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Ectopic retinoic acid signaling affects outflow tract cushion development through suppression of the myocardial Tbx2 Tgfβ2 pathway
... Tbx2 transcriptional activation through the functional RARE during OFT ...Luc activity by RA (blue bars), although the Luc activity was not affected by RA, as determined using the Tbx2-Luc-mRARE ...
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NKX2-1-mediated p53 expression modulates lung adenocarcinoma progression via modulating IKKβ/NF-κB activation
... promoter activity was not observed in H23 cells when the putative binding site of NF-Y to the P3 promoter was mutated by site-directed mutagenesis (Figure 5C lower ...addition, p53 expression was higher in ...
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The K-bZIP Protein from Kaposi's Sarcoma-Associated Herpesvirus Interacts with p53 and Represses Its Transcriptional Activity
... protein p53 in vitro as well as in vivo and to repress the ability of p53 to activate to transcrip- ...with p53 and determine the effects of K-bZIP binding on p53 ...
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The p53 complex from monkey cells modulates the biochemical activities of simian virus 40 large T antigen.
... i T+p53 has an enhanced ATPase specific activity 40; ii all subclasses of T that have altered ATPase activity also have altered amounts of bound p53 40; iii the coordinates of the p53 bi[r] ...
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