painful neuropathy
CR4056, a new analgesic I2 ligand, is highly effective against bortezomib-induced painful neuropathy in rats
... Abstract: Although bortezomib (BTZ) is the frontline treatment for multiple myeloma, its clinical use is limited by the occurrence of painful peripheral neuropathy, whose treatment is still an unmet ...
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Fibromyalgia and neuropathic pain - differences and similarities. A comparison of 3057 patients with diabetic painful neuropathy and fibromyalgia
... Pressure induced pain, i.e. deep somatic hyperalgesia, is thought to be characteristic for fibromyalgia, as is reflected in the ACR-criteria. Hyperactive nociceptive processing from sensitized nociceptors innervating ...
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Identification, prevalence, and treatment of painful diabetic neuropathy in patients from a rural area in South Carolina
... Presbyterian College School of Pharmacy (PCSP) Wellness Center is a pharmacist-run DSME/S program located in rural Laurens County, South Carolina. This program serves patients who are located in Laurens County or ...
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Guidelines in the management of diabetic nerve pain clinical utility of pregabalin
... pose for the management of painful neuropathy in diabetes. This presumes that the cause of the pain has been attributed to DPN and that all causes masquerading as DPN have been excluded. The identification ...
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PHARMACOLOGICAL EVALUATION OF Passiflora incarnata ON VINCRISTINE INDUCED NEUROPATHY IN RATS
... 2342 Treatment with hydroethanolic extract of Passiflora incarnata (HEEPI) and pregabalin significantly attenuated vincristine-induced behavioural, biochemical and histopathological changes, and hence the painful ...
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Pharmacognostical, Phytochemical and Pharmacological Evaluation of The Leaves of Ipomoea Sepiaria Koen. Ex Roxb.
... Isolated compounds obtained by column chromatography such as mixture-I, mixture-II and single compound were evaluated for antioxidant activity by DPPH radical scavenging method. Mixture-II exhibited potent antioxidant ...
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Maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine
... for painful diabetic neuropathy are based upon clinical experience and pooled data from trials with relatively small sample sizes, nonstan- dardized markers of efficacy, and short follow-up ...
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Association of patient-rated severity with other outcomes in patients with painful diabetic peripheral neuropathy
... The relationship between severity of neuropathic pain sensations and severity of the most commonly painful body part was specifically evaluated using the nonparametric Spearman rank correlation. Overall ...
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Translation and cultural adaptation of the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) pain scale into Arabic for use with patients with diabetes in Libya
... During study visit 1, participants were briefed about the study, screened for eligibility and enrolled onto the study by signing a consent form. Demographic data, such as age, weight and height, were also collected to ...
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Painful Diabetic Neuropathy: A Management-Centered Review
... The physical exam should also evalu- ate for signs of decreased arterial flow, altered reflexes, deformities, ulcers, or slow-healing wounds. Signs of decreased arterial flow may include absence of foot pulses, decrease ...
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A cross sectional study to estimate the point prevalence of painful diabetic neuropathy in Eastern Libya
... Painful Diabetic Neuropathy (PDN) is a common com- plication of diabetes affecting up to one third of patients worldwide. Diagnosis, treatment and management of PDN can be challenging for clinicians because ...
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<p>Integrating Machine Learning With Microsimulation to Classify Hypothetical, Novel Patients for Predicting Pregabalin Treatment Response Based on Observational and Randomized Data in Patients With Painful Diabetic Peripheral Neuropathy</p>
... for painful diabetic peripheral neuropathy, utilizing an agent-based modeling and simulation platform that integrates real-world observational study (OS) data and randomized clinical trial (RCT) ...
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Sodium channels gone wild: resurgent current from neuronal and muscle channelopathies
... mutations associated with painful neurop- athy (i.e., in the peripheral neuronal sodium channel Nav1.7 isoform), cardiac arrhyth- mia (i.e., in the cardiac myocyte sodium channel Nav1.5), or myotonia of skeletal ...
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ARA 290 Improves Symptoms in Patients with Sarcoidosis-Associated Small Nerve Fiber Loss and Increases Corneal Nerve Fiber Density
... The most prevalent form of small-fiber neuropathy occurs in patients with predi- abetes or diabetes, and in this group, reti- nal edema and visual acuity changes are very common. Additionally, another major ...
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Electroacupuncture to treat painful diabetic neuropathy: study protocol for a three armed, randomized, controlled pilot trial
... Acupuncture has long been used in East Asia for pain relief based on the Qi theory, and acupuncture can re- duce pain by regulating the imbalance of Qi. In the West, acupuncture has increasingly been a recent sub- ject ...
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A study of Clinical and Electrophysiological correlation in patients with Alcoholic Neuropathy.
... alcoholic neuropathy patients had autonomic symptoms and it showed that there is no parallel involvement of somatic and autonomic fibers in alcoholic ...autonomic neuropathy was common in alcoholic ...
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<p>Ameliorative Effects Of N-Acetylcysteine As Adjunct Therapy On Symptoms Of Painful Diabetic Neuropathy</p>
... study, painful distal symmetrical and sensorimotor poly- neuropathy attributable to DM ≥ 3 months, score of ≥ 40 mm on the visual analog scale of the short-form McGill Pain Questionnaire (SF-MPQ), and ...
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Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials
... We identified six trials satisfying the inclusion criteria [30- 35]. Details of the included studies are in Additional File 1. A total of 2,216 patients were included, 1,510 treated with duloxetine and 706 with placebo. ...
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<p>Acetyl-L-carnitine in painful peripheral neuropathy: a systematic review</p>
... Several experimental models of neuropathic pain documented the antinociceptive effect of ALC; such model encompassed streptozotocin- and chemotherapy- induced neuropathy, as well as the sciatic nerve chronic ...
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REVIEW ARTICLE Diabetic neuropathy and painful diabetic neuropathy: Cinderella complications in South East Asia
... In a small cross-sectional study in 2006 in the outpatient department of BIRDEM Hospital, a tertiary care centre in Dhaka, 294 randomly selected patients with Type 2 Diabetes Mellitus (T2DM) aged 50.8±10.6 years ...
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