Pancreatic β cell failure
Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice
... Pancreatic β cell failure is thought to underlie the progression from glucose intolerance to overt diabetes, and ER stress is implicated in such β cell ...protein β ...
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Insulin resistance and pancreatic β cell failure
... Mice that lack insulin receptors in adipocytes are lean and are protected against obesity-related glucose intolerance 7, suggesting that insulin signaling in adipocytes per se may not co[r] ...
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DPP 4 Inhibition Ameliorates Pancreatic β Cell Failure and Improves Glucose Tolerance in the Mouse Model of Wolfram Syndrome
... outside β-cells of Wolfram syndrome, such as diabetes insipidus and optic atrophy, can be suppressed by incretin-based ...wolframin-deficient β-cells have been generated from human induced pluripotent stem ...
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MicroRNA 7a regulates pancreatic β cell function
... in pancreatic islets of Tg7a2 and BKS db/db diabetic mice, suggestive of regression of β cells to a developmental precursor ...endocrine β cells during development, but not in the adult pancreas ...
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Progressive β Cell Failure in Type 2 Diabetes Mellitus: Microvascular Pancreatic Isletopathy?
... their β cell function: 1) β cell failure ( β − ve) defined as HbA1c > ...2) β cell function “preserved” ( β + ve) with HbA1c ≤ ...
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A CCR2+ myeloid cell niche required for pancreatic β cell growth
... significant β cell loss, pancreatic cells may reactivate regenerative programs, leading to some recovery of the islet cell mass through prolif- eration of remnant β cells or ...
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Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes
... The failure of pancreatic b cells to adapt to an increasing demand for insulin is the major mechanism by which patients progress from insulin resistance to type 2 diabetes (T2D) and is thought to be related ...
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Original Article Pyruvate kinase, muscle isoform 2 promotes proliferation and insulin secretion of pancreatic β-cells via activating Wnt/CTNNB1 signaling
... Abstract: Failure of pancreatic β-cells is closely associated with type 2 diabetes mellitus (T2DM), an intractable disease affecting numerous ...in pancreatic β-cells. Mouse ...
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Neuronatin regulates pancreatic β cell insulin content and secretion
... and β cell apoptosis, in a form of diabetes termed mutant insulin gene–induced diabetes of youth (MIDY) (25, 26, 40, ...this β cell stress from mutant insulin species dictates the outcome of ...
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Regeneration of the pancreatic β cell
... of β cells should become virtually defined at a certain point, and, afterward, glycemia should be controlled only by that defined cellular ...differentiated β cells (defined as postnatal cells transcribing ...
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Neonatal Pancreatic β-Cell Hyperplasia: Report of a Case With Failure of Diazoxide and Benefit of Early Subtotal Pancreatectomy
... We are aware of one previous report of a 9-year-old boy with diffuse a-cell hyperplasia whose chronic hypoglycemia was not controlled by diazoxide.’2 Diazoxide was also ineffective thera[r] ...
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Pancreatic β- and α-cell adaptation in response to metabolic changes
... van β-cellen ...de β-cellen. Na 22 weken was de β-celmassa kleiner in ketogeen dieet-gevoede muizen vergeleken met ...de β-celmassa, maar geen ...
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β1 integrin is a crucial regulator of pancreatic β cell expansion
... 2003), cell differentiation and proliferation (Kaido et ...in pancreatic endocrine cells (Kaido et ...regulate cell attachment to specific ECMs and the migration of undifferentiated pancreatic ...
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Biochemical And Functional Studies Of Histone Deacetylase 3 In Metabolic Tissues
... the β-cells could be beneficial for diet induced obesity as the body struggles to maintain glucose ...the β-cell knockout of HDAC3, perfusion experiments would be highly ...of β-cell ...
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Islet β cell failure in type 2 diabetes
... b cell failure in the pathogenesis of obesity-associated type 2 diabetes ...b cell compensation for insulin resistance, consid- eration is also given to the mechanisms involved in the compensation ...
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Extracellular Signals and Pancreatic β-cell Development: A Brief Review
... The Wnt genes encode a large family of secreted glycoprotein growth factors (19 in humans) (71). The Wnt genes are highly conserved between verte- brates, sharing overall sequence identity. Once se- creted, Wnt proteins ...
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Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration
... that pancreatic acinar cells can serve as progenitors for pancreatic islets, a concept with substantial implications for therapeutic efforts to increase insulin-producing β cell mass in ...
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Targeted Epigenetic Editing to Increase Adult Pancreatic Β-Cell Proliferation
... secreting pancreatic juices with digestive enzymes into the small ...levels. Pancreatic islets are vascularized spheroid clusters of endocrine cells scattered throughout the pancreas comprising only about ...
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Cellular reprogramming for pancreatic β-cell regeneration: clinical potential of small molecule control
... producing β-cells ...adult β-cells ...the β-cells from pancreatic endoderm to specify four endocrine cell lineages of the pancreas ...of β-cells from patients with DM ...the ...
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Coenzyme Q10 suppresses apoptosis of mouse pancreatic β-cell line MIN6
... of β‑cells caused by mitochondrial stress plays an important role in impaired insulin ...on pancreatic β‑cells against mitochondrial stress using mouse pancreatic β‑cell line ...
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