parent-of-origin
Asymmetric paternal effect on offspring size linked to parent of origin expression of an insulin like growth factor
... a parent- of- origin methylation pattern, where the maternally inherited igf2 allele has much more 5′ cytosine methylation than the paternally inherited ...the parent- of- origin methylation ...
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Parent-of-origin-specific allelic expression in the human placenta is limited to established imprinted loci and it is stably maintained across pregnancy
... exhibiting parent-of-origin-specific al- lelic ...of parent-of-origin expression and reporting novel imprint- ing candidate genes in either human term placentas ( n = 10, [15]) or early ...
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Parent-of-Origin Effects on mRNA Expression in Drosophila melanogaster Not Caused by Genomic Imprinting
... parent-of-origin effects in the microarray study, were also examined. For each gene, expression was measured in 7- to 10-day-old mated females (Ore, 2b, O2b, 2bO) from each cross (Ore 3 Ore, 2b 3 2b, Ore 3 ...
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GWAS of DNA Methylation Variation Within Imprinting Control Regions Suggests Parent-of-Origin Association
... multivariate and family-based models of association, we were able to make a better use of the evidence contained in both the genotype and phenotype data. Furthermore, the fact that we were able to detect associations ...
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Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
... Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and ...
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Epigenetic Variation, Inheritance, and Parent-of-Origin Effects of Cytosine Methylation in Maize (Zea mays)
... ABSTRACT Pure epigenetic variation, or epigenetic variation that is independent of genetic context, may provide a mechanism for phenotypic variation in the absence of DNA mutations. To estimate the extent of pure ...
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Novel parent-of-origin-specific differentially methylated loci on chromosome 16
... While we identified suggestive evidence of parent-of-origin biases in DNA methylation at 16q24.1, it is also possible that larger imprinted loci exist in this region whose differential methylation might ...
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Copy number variation in Y chromosome multicopy genes is linked to a paternal parent of origin effect on CNS autoimmune disease in female offspring
... One outcome of intragenomic conflict is the preferen- tial transmission of genetic elements to offspring at a higher frequency than the expected 1:1 Mendelian ratio [7]. These genetic elements are referred to as ...
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Parent of origin specific gene expression and dispersal
... Genes can behave in ways that are conditional upon their parent-of-origin. The best understood form of this is genomic imprinting (GI), which typically involves the silencing of a gene originating from one ...
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Parent-of-Origin-Effect rough endosperm Mutants in Maize
... The mre and pre endosperm defects suggest several developmental mechanisms that can give rise to parent- of-origin kernel defects. Defective or delayed BETL cell differentiation was observed in all mutants. ...
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Genome wide association study identifies a susceptibility locus for comitant esotropia and suggests a parent of origin effect
... to reports of linkage to chromosome 7p22.1 (STBMS1 locus, Online Mendelian Inheritance in Man [OMIM]185100) under a recessive 24 and a dominant 25 inheritance model, respectively. A third study combined small Japanese ET ...
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Indirect Genetic Effects for Survival in Domestic Chickens (Gallus gallus) Are Magnified in Crossbred Genotypes and Show a Parent-of-Origin Effect
... Alternatively, maternal imprinting, where only paternally inherited alleles are expressed, could explain the observed parent-of-origin effect. Imprinting in animals is assumed to be a phenomenon exclusive ...
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A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent of origin effects
... In this study, we generated a new Xist allele (Xist CAG ) that was driven by a CAG promoter, which is considered one of the strongest and most ubiquitous promoters (Niwa et al., 1991). We expected that this allele, when ...
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The genetic architecture of the DDK syndrome: an early embryonic lethal phenotype in the mouse
... is parent of origin dependent and results from an incompatibility between an ooplasmic DDK factor and a non- DDK paternal gene, both of which map to the Ovum mutant (Om) locus on chromosome ...
150
A Novel Statistical Approach for Jointly Analyzing RNA-Seq Data from F1 Reciprocal Crosses and Inbred Lines
... To evaluate the performances of the proposed models when the model assumptions are violated, we next gener- ated a new set of data, using the Flux Simulator (Griebel et al. 2012), which models RNA-seq experiments in ...
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Genetics of Adverse Reactions to Haloperidol in a Mouse Diallel: A Drug–Placebo Experiment and Bayesian Causal Analysis
... In choosing a transformation f, we balance interpretabil- ity of parameter estimates with a concerted attempt to sat- isfy the model’s assumptions of residual normality; when the two are in strong conflict, we favor ...
203
Sexual selection modulates genetic conflicts and patterns of genomic imprinting
... These disorders may not be altogether independent of the male-harm behaviors that have been the focus of our study, as selflessness in sexual conflict is simply one facet of a range of cooperative versus competitive ...
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The PEG13 -DMR and brain-specific enhancers dictate imprinted expression within the 8q24 intellectual disability risk locus
... shows parent-of-origin allelic expression in mouse brain, and includes the maternally expressed Kcnk9 [16], Trappc9, Chrac1 and Ago2 (also known as Eif2c2) genes, clustered around the paternal Peg13 ncRNA ...
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Parental genome imbalance in Brassica oleracea causes asymmetric triploid block
... The behaviour of parental genomes in developing seeds resulting from imbalanced crosses may be influenced in two ways. The first is due to differential expression of maternal and paternal alleles depending on their ...
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Parent Relations.pdf
... An affiliate organization can be a terrific involvement opportunity for the parents of your members. Your parent relations program should be solid before accepting the challenges of starting a new organization. ...
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