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PARP1 inhibitor

PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas

PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas

... to PARP1 inhibitors [14, 15]. Therefore, PARP1 inhibitors may be highly effective drugs in variety of tumors with germline or somatic defects in DNA damage repair ...that PARP1 inhibitor ...

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PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity

PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity

... Untreated cells were used as a negative control. Finally, we used SIRT1 short-hairpin RNA (Ad-sh-SIRT1) to si- lence SIRT1 expression in EPCs and measured the ef- fects of PJ34 again. We measured and evaluated ...

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Original Article Polymorphisms in poly (ADP-ribose) polymerase-1 (PARP1) promoter and 3’ untranslated region and their association with PARP1 expression in breast cancer patients

Original Article Polymorphisms in poly (ADP-ribose) polymerase-1 (PARP1) promoter and 3’ untranslated region and their association with PARP1 expression in breast cancer patients

... pathway, PARP1 inhibitors were originally exploited to treat breast cancer patients with BRCA mutations [11, 12, ...of PARP1 inhibitors in ...Thus, PARP1 inhibitors alone, or in combination with DNA- ...

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PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells

PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells

... another PARP1 inhibitor, showed stronger protective effects on H 2 O 2 -treated cells than veliparib (Figure 2, A and B, and Supple- mental Figure 1, A and B), which might be explained by additional ...

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The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer

The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer

... PARP inhibitor AG014699 delayed growth of xenograft tumor generated from TNBC cell MDA-MB-436 and HCC1937 which carried BRCA1 mutation more markedly in contrast with xenograft tumors with BRCA1/2-nonmutated breast ...

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Poly(ADP-Ribose) Polymerase 1-Sirtuin 1 Functional Interplay Regulates LPS-Mediated High Mobility Group Box 1 Secretion

Poly(ADP-Ribose) Polymerase 1-Sirtuin 1 Functional Interplay Regulates LPS-Mediated High Mobility Group Box 1 Secretion

... if PARP1 inhibition alters LPS-mediated HMGB1 hyperacetylation and subsequent secretion due to its effect on ...with PARP1 inhibitors mit- igates the LPS-mediated reduction in nuclear HDAC activity and ...

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Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications

Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications

... of PARP1 mRNAs as well as proteins (Figure 2C, ...of PARP1 inhibition is mediated, at least in part, by FOXO3A activation, although further studies might be required to address direct signaling mechanisms ...

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Radioiodinated PARP1 tracers for glioblastoma imaging

Radioiodinated PARP1 tracers for glioblastoma imaging

... With the aim of determining the potential of radioiodi- nated I2-PARPi as a glioblastoma imaging agent, small animal SPECT/CT and PET/CT studies were performed in athymic nude mice bearing orthotopic U251 MG xe- ...

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Pharmacogenomic analysis indicates potential of 1,5-isoquinolinediol as a universal anti-aging agent for different tissues

Pharmacogenomic analysis indicates potential of 1,5-isoquinolinediol as a universal anti-aging agent for different tissues

... we utilized a connectivity map, a recently developed tool to investigate connections among small molecules that share a mechanism of action, chemical and physiological processes, and diseases and drugs [20]. This ...

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Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer

Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer

... proteasome inhibitor MG-132 (Figure 1H) or after the additional deletion of the RING domain (Figure 1I) in Calu-6 ...of PARP1’s polymerase activity by the PARP-inhibitor ABT-888 did not result in ...

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Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib

Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib

... In contrast, inhibition of PARG resulted in faster repair of IR-in- duced DNA damage and concomitant rapid activation of significantly higher levels of DNA-PKcs. NHEJ involving DNA-PKcs is thought to predominate during G1 ...

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Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity

Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity

... Mitochondria isolation and membrane fractionation. HEK-293 cells were incubated with solvent (0.1% DMSO) or 3 μM 19,20-DHDP in serum-free medium and cultured in incubators supplied with 21% or 75% O 2 with 5% CO 2 at ...

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Original Article Synergistic role between Cul1 and PARP1: prognostic and predictive biomarkers in colorectal cancer

Original Article Synergistic role between Cul1 and PARP1: prognostic and predictive biomarkers in colorectal cancer

... of PARP1 was increased in CRC tissues as compared with matched adjacent ...of PARP1 was correlated with the reduced overall survival of CRC ...regulate PARP1 in the regulation of tumor apoptosis ...

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A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF

A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF

... The correlation between the risk allele and higher levels of PARP1 expression 299 was highly reproducible across multiple melanoma-relevant tissues, including early-passage 300 melanoma [r] ...

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Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ

Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ

... We next examined whether the greatly reduced level of PNKP protein and activity in the patient cells affected the rate of DNA strand break repair. DNA strand breaks induced by abortive topoisomerase 1 (TOP1) activity ...

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Global proteomic profiling in multistep hepatocarcinogenesis and identification of PARP1 as a novel molecular marker in hepatocellular carcinoma

Global proteomic profiling in multistep hepatocarcinogenesis and identification of PARP1 as a novel molecular marker in hepatocellular carcinoma

... markers, PARP1, GS and NDRG1 showed the optimal diagnostic performance for ...HCC. PARP1, as a novel marker, showed comparable diagnostic performance to that of classic markers GS and NDRG1 in HCC (AUCs = ...

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Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

... being efficiently shuttled through the downstream BER steps (Figure 1A). Both SSBs and AP sites exert their toxicity as a function of blocking transcription and replication [11]. Further, large numbers of SSBs can ...

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Discriminating radiation injury from recurrent tumor with [18F]PARPi and amino acid PET in mouse models

Discriminating radiation injury from recurrent tumor with [18F]PARPi and amino acid PET in mouse models

... demonstrated no increase in [ 18 F]FET uptake in animal models of inflammation [50–52]. Perhaps more likely, low-affinity interactions may increase the residence time of tracers in cellular or extracellular compartments, ...

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Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner

Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner

... Nephrotoxicity is a common toxic side-effect of chemotherapeutic alkylating agents. Although the base excision repair (BER) pathway is essential in repairing DNA alkylation damage, under certain conditions the initiation ...

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Integrating a Next Generation Sequencing Panel into Clinical Practice in Ovarian Cancer

Integrating a Next Generation Sequencing Panel into Clinical Practice in Ovarian Cancer

... Results: Of the 84 patients, 55 (65.1%) had high-grade serous carcinomas. Seventy-three (86.7%) patients underwent NGS at the time of diagnosis, and 11 (13.3%) underwent NGS upon relapse. The most common genetic ...

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