Pediatric Crohn's disease
Psychological wellbeing and physical activity in children and adolescents with inflammatory bowel disease compared to healthy controls
... and pediatric Crohn’s disease activity index (CDAI), partici- pants in the present study were split into those with medically optimized treatment (IBD in remission, PUCAI <10; CDAI <150) the IBD – RE ...
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Profile of infliximab in the treatment of pediatric Crohn’s disease
... Infliximab, a biologic anti-TNF- α agent, has revolutionized the treatment of pediatric CD. According to the available data, the drug is highly effective in induction and mainte- nance of remission in children ...
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Difficult-to-treat-pediatric Crohn's disease: focus on adalimumab
... in pediatric patients with moderate to severe disease and used earlier in the disease course as first-line rather than as “rescue” follow- ing failure of “conventional” ...selected pediatric ...
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Systematic review with meta-analysis: the efficacy and safety of stem cell therapy for Crohn’s disease
... exclusively pediatric patients (<15 years), a diagnosis of ulcerative colitis, indeterminate colitis, or an unclear diag- nosis of CD and case reports were also ...
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Inflammatory bowel disease-specific health-related quality of life instruments: a systematic review of measurement properties
... bowel disease;; CD: Crohn ’ s disease; CGQL: Cleveland global quality of life; CLIQ: Crohn ’ s life impact questionnaire; COSMIN: Consensus-based standards for the selection of ...
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Genetic variants associated with Crohn's disease
... predict disease behavior as well as the response to certain immune ...with pediatric early onset, thus allowing us the capability to identify children at a higher risk of disease and provide a more ...
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Pediatric Crohn's disease: epidemiology and emerging treatment options
... Delivery systems include enemas or suppositories, which provide the drug to the rectum and left colon; coating with pro- tective materials that release the drug in a pH-dependent man- ner to achieve controlled (Pentasa, ...
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Infliximab therapy in pediatric Crohn’s disease: a review
... bowel disease of increased severity. Moreover, pediatric CD is often associated with extra intestinal manifestations, including arthritis, episcleritis, uveitis and erythema ...
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Gender Differences in Presentation and Course of Disease in Pediatric Patients With Crohn Disease
... the Pediatric IBD Consortium Registry began in January 2000 from centers located in 6 geo- graphically distinct regions: (1) University of California, San Francisco, Children’s Hospital, and Kaiser Perma- nente of ...
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Leistner, Dorothea (2011): Die Rolle des CXCL16 p.Ala181Val-Polymorphismus bei chronisch entzündlichen Darmerkrankungen. Dissertation, LMU München: Medizinische Fakultät
... M. Crohn überhaupt gestellt wird, können in der Mundhöhle schon initiale Anzeichen der Erkrankung erkennbar werden (Coenen et ...M. Crohn Patienten treten orale Manifestationen in Form von Aphten, ...
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Managing refractory Crohn's disease: challenges and solutions
... Abstract: The goals of treatment for active Crohn’s disease (CD) are to achieve clinical remis- sion and improve quality of life. Conventional therapeutics for moderate-to-severe CD include 5-aminosalicylic acid, ...
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Management of Crohn's disease in poor responders to adalimumab
... One area of future research includes the use of trough levels and antibody formation to affect optimization of adali- mumab treatment. Hence, well-designed prospective trials that focus on this particular issue are ...
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Disease-related information requirements in patients with Crohn’s disease
... the disease, in regard to their ...the disease can be controlled, so many women of a gestational age have a desire for fertility and obviously have a high demand for related ...good disease behavior ...
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Hospital admissions for vitamin D related conditions and subsequent immune-mediated disease: record-linkage studies
... admission) reduces vitamin D levels as a result of an in- flammatory state and/or causes the individual to spend less time outdoors [16]. The increasing awareness of vitamin D may also lead to an increase in requests for ...
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Infliximab to treat Crohn’s disease: an update
... study included 94 patients who were unresponsive to at least 3 months of conventional therapy who were randomly assigned to receive three doses of IFX (5 or 10 mg/kg) or placebo at weeks 0, 2, and 6. After a follow-up of ...
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Cognitive-behavioural therapy has no effect on disease activity but improves quality of life in subgroups of patients with inflammatory bowel disease: a pilot randomised controlled trial
... Crohn’s Disease Activity Index (CDAI) [25] for those with CD or the Simple Clinical Colitis Activity Index (SCCAI) [26] for those with UC as ...appropriate. Disease activity was also monitored using blood ...
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Neonatal Crohn’s disease with Oral ulcer as the first symptom caused by a compound heterozygote mutation in IL-10RA: a case report
... variants of MSH5 and CD19 in early IBD in newborns [30]. Huang Z et al. found that C301C > T (p.R101RW) and c.537G > A (PT179 T) were the most common mu- tations of the IL-10RA gene, accounting for 88.1% of all ...
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Schwerd, Tobias (2019): Chronisch entzündliche Darmerkrankungen bei Kindern und Jugendlichen: von molekularen Mechanismen zu therapeutischen Ansätzen. Habilitationsschrift, LMU München: Medizinische Fakultät
... Im ersten Teil wurden bei Patienten mit seltenen monogenen Erkrankungen, welche mit einer CED assoziiert sind, Mechanismen beschrieben, die zu einer Störung der intestinalen Homöostase führen. So haben Patienten mit der ...
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Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension with active Crohn’s disease
... After undergoing thorough treatments for active IBD, PEA using intermittent circulatory arrest under deep hypothermia was performed (Fig. 3). PEA was performed through a median sternotomy using cardiopulmonary bypass ...
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Measuring disease activity in Crohn's disease: what is currently available to the clinician
... of disease in each segment showed good reproducibility, but for extramural MRI features (perimural T2 signal, comb sign, and lymph nodes) only fair reproducibility was observed (the absence of severe patients may ...
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