perfused rat liver
Study of the Biotransformation of Benfluron Using the Isolated Perfused Rat Liver
... isolated perfused rat liver method (IPRL) was used to find, isolate and identify further metabolites of Phase I and Phase II biotransformation of the potential cytostatic agent benfluron with special ...
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Thyroxine uptake by perfused rat liver No evidence for facilitation by five different thyroxine binding proteins
... isolated perfused rat liver using an indicator dilution ...albumin, rat TBPA, and human albumin isolated from subjects with familial dysalbuminemic ...
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Synthesis and release of Hageman factor (Factor XII) by the isolated perfused rat liver
... isolated perfused rat liver and have compared rates of synthesis in this system with absolute rates of degradation measured in ...vivo. Rat livers, perfused for 5 h with a recycling ...
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Hepatic bilirubin uptake in the isolated perfused rat liver is not facilitated by albumin binding
... albumin. Rat liver was perfused with a protein-free fluorocarbon medium, and single-pass uptake of 1, 10, or 200 nmol of [3H]bilirubin was determined after injection as an equimolar complex with ...
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Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver
... Administration of a heme oxygenase inhibitor zinc protoporphyrin IX 1 ,uM eliminated the baseline CO generation, and the vascular resistance exhibited a 30% elevation concurrent with dis[r] ...
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DNA SYNTHESIS IN THE ISOLATED PERFUSED RAT LIVER EUR 308 e
... A liverlobe was removed before the second addition of thymidine and at the end of the perfusion 4-5 hours after the start of the perfusion DNA was isolated from the liversamples, and its[r] ...
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Sinusoidal efflux of glutathione in the perfused rat liver Evidence for a carrier mediated process
... the rat is almost entirely accounted for by cellular efflux, of which 80-90% is ...isolated rat livers perfused in situ, single pass, with hemoglobin-free, oxygenated buffer medium at pH ...
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Protoporphyrin induced Cholestasis in the Isolated In Situ Perfused Rat Liver
... of liver disease in protoporphyria has been presumed to result from the hepatic deposition of ...situ, rat liver perfusion system. Rat livers in the control group were perfused with ...
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Influence of Cl on organic anion transport in short term cultured rat hepatocytes and isolated perfused rat liver
... Transport of 35S-labeled sulfobromophthalein [35S]BSP was studied in short-term cultured rat hepatocytes incubated in bovine serum albumin. At 37 degrees C, initial uptake of [35S]BSP was 5-10-fold that at 4 ...
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Reactive oxygen species during ischemia reflow injury in isolated perfused rat liver
... isolated perfused livers of male Fischer ...the liver was reperfused for another 60 ...gram liver weight), the biliary efflux of total glutathione ...livers perfused for the same period of ...
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Discoidal bilayer structure of nascent high density lipoproteins from perfused rat liver
... livers perfused with the inhibitor appeared disk-shaped in negative stain by electron microscopy with a mean edge thickness of 46 +/- 5 A and a mean diameter of 190 +/- 25 ...
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The regulation of 3 hydroxy 3 methylglutaryl coenzyme A reductase in the isolated perfused rat liver
... In liver removed during the basal period of the diurnal cycle of enzyme activity, a 227 +/- 41% increase in enzyme activity occurred after 3 h of a plasma-free ...the rat failed to prevent the increase in ...
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Coordinate pulsatile insulin secretion by chronic intraportally transplanted islets in the isolated perfused rat liver
... isolated perfused livers at 10 mM glucose from 27 rats rendered diabetic with streptozotocin and then transplanted with approximately 2 x 10(3) islets, 2 (n = 5), 7 (n = 5), 30 (n = 5), and 200 (n = 12) d after ...
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Albumin mediated transport of rose bengal by perfused rat liver Kinetics of the reaction at the cell surface
... If binding of albumin-ligand complexes to the cell surface mediates ligand removal, it should be possible to predict the number of cell surface sites and their affinity for albumin from [r] ...
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Synthesis of Essential Amino Acids from Their α Keto Analogues by Perfused Rat Liver and Muscle
... isolated rat liver and hindquarter (muscle) preparations were perfused with keto-analogues of valine, leucine, isoleucine, methionine, or ...When perfused at ...the liver of 48-h ...
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Effects of Ranolazine on Carbohydrate Metabolism in the Isolated Perfused Rat Liver
... Since ranolazine inhibits oxygen uptake, it seems reasonable to assume that this also represents diminished mitochondrial ATP production. Corroborating this, a diminution of the ATP content was found in the ...
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Clearance of Immunoreactive Somatostatin by Perfused Rat Liver
... Other investigators have demonstrated that concentrations of immunoreactive somatostatin (IRS) are higher in blood from the hepatic portal vein or its tributaries than in blood from the hepatic or peripheral systemic ...
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Regulation of the Conversion of Thyroxine to Triiodothyronine in the Perfused Rat Liver
... the liver. The perfused liver readily extracted T 4 from perfusion medium and converted it to T 3 ...the perfused liver was a function of the size of the liver, the uptake of T 4 ...
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Synthesis of clotting factors by the isolated perfused rat liver
... The slight shortening of the Factor X assay clotting time is surmised to reflect the absence of Factor X activity in adsorbed rat serum sample 1 and the presence of some Factor X activi[r] ...
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Influence of Thyroid Status on Lipid Metabolism in the Perfused Rat Liver
... Thyroid disease is often accompanied by changes in the concentrations of serum lipids and lipoproteins. To evaluate the hepatic contribution to the serum abnormalities in thyroid disease, we examined fatty acid ...
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