persistent sodium currents
The modulation of two motor behaviors by persistent sodium currents in Xenopus laevis tadpoles
... by persistent sodium currents in Xenopus laevis ...doi:10.1152/jn.00755.2016.—Persistent sodium currents (I NaP ) are common in neuronal circuitries and have been implicated in ...
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Breakdown of accommodation in nerve: a possible role for persistent sodium current
... without persistent sodium currents were stimulated by linearly ris- ing currents, non-linear responses always resulted in action potentials when the model exhibited breakdown of ...
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Klinger, Alexandra Birgit (2013): Zur Wirkung des Seeanemonen Toxins II (ATX-II) auf spannungsgesteuerte Natriumionenkanäle neuronaler Zellen und zu den dadurch erreichten Änderungen im Schmerzempfinden. Dissertation, LMU München: Tierärztliche Fakultät
... resurgent currents were described in small diameter DRGs [14], and accordingly, we were unable to detect any significant resurgent or persistent sodium currents in sensory neurons <25 μm ...
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Solution structure of μ-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels
... and persistent TTX-sensitive subtypes. Selective inhibition of persistent over transient VSSCs may control seizures, where the accompanying slow persistent sodium currents might be ...
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<p>Voltage gated sodium channels as therapeutic targets for chronic pain</p>
... Nav1.9 mediates a TTX-R current that is challenging to study due to current instability and poor expression in heterologous systems. 58,59 Nav1.9 characteristically acti- vates at hyperpolarized potentials and displays ...
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Mechanisms contributing to the dopamine induction of crawl like bursting in leech motoneurons
... coupled to adenylyl cyclase activity (Ali et al., 1998). This activity, in turn, increases the cytoplasmic concentration of cAMP, thus enhancing protein kinase A (PKA) activity and the serine/threonine phosphorylation of ...
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Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice.
... Changes in sodium channel activity and neuronal hyperexcitability contribute to neuropathic pain, a major clinical problem. There is strong evidence that the re-expression of the embryonic voltage- gated ...
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Mixed mode oscillations in mouse spinal motoneurons arise from a low excitability state
... the sodium current is likely responsible for the low membrane ex- citability of mouse ...motoneurons. Sodium channels are endowed with multiple time constants for their slow inactivation, rang- ing from 100 ...
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PHARMACOLOGICAL CHARACTERIZATION OF Bunodosoma TOXINS ON MAMMALIAN VOLTAGE DEPENDENT SODIUM CHANNELS
... gated sodium channels in different excitable ...different sodium channels (from ...cloned sodium channels expressed in Xenopus laevis oocytes 9 ...
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Enhancement of dendritic persistent Na+ currents by mGluR5 leads to an advancement of spike timing with an increase in temporal precision
... is activated by intracellular Ca 2+ release via cADPR/rya- nodine receptor (RyR) pathway [32]. However, Park et al. [20] showed that mGluR-dependent increase in R-type Ca 2+ currents mediates ADP generation by ...
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A computational study of the mammalian subiculum
... introduction during the early 50's. Perhaps the most significant is the discovery that the channel inactivation process is not independent of activation (Hille. 1992), as is assumed in the HH approach. The ability of the ...
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Can nocturnal hypertension predict cardiovascular risk?
... two most cited explanations rest on abnormal renal sodium handling and disturbances in nocturnal autonomic or sympa- thovagal balance. Further, the association of nocturnal hyper- tension and non-dipping pattern ...
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Sodium dependent norepinephrine induced currents in norepinephrine transporter transfected HEK 293 cells blocked by cocaine and antidepressants
... (GU)-induced currents in 293- hNET ...inward currents at each ...steady-state currents. The difference currents (NE 2 CO) and (GU 2 CO) illustrated in A are plotted against the test voltage ...
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Octopamine increases the excitability of neurons in the snail feeding system by modulation of inward sodium current but not outward potassium currents
... by a single exponential raised to a power between 1 and 4. While Connor & Stevens' data [14,15] was fitted with the product of two terms, we achieved a better fit using the sum of two processes, suggesting that the ...
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NaV1.1 inhibition can reduce visceral hypersensitivity
... Metabolic stability of Compound B in plasma and liver microsomes. Plasma stability was evaluated using plasma from mice and humans as described previously (41, 42). Briefly, Compound B (10 μM) was spiked in plasma and ...
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Mathematical model of bursting in dissociated Purkinje neurons
... The mechanism of the isolated soma’s spontaneous bursting is incompletely understood. Swensen and Bean [12] studied bursts in this experimental preparation; but they parsed the ionic basis to an imposed, elicited burst ...
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The Revitalization of the Community based Management of Acute Malnutrition Program in Haiti
... fast sodium, persistent sodium, and calcium currents at the spike ...the persistent sodium current reproduced the dantrolene effects on spike shape and reduced the calcium influx ...
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Reversal of lidocaine effects on sodium currents by isoproterenol in rabbit hearts and heart cells
... voltage-dependent sodium currents (INa) in rabbit ventricular myocytes through dual G-protein regulatory ...the sodium channel blocking effects of class I antiarrhythmic drugs through modulation of ...
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Design and development of a new dedicated RF sensor for the MRI of rat brain
... acquire sodium image of a phan- tom containing a sodium concentration as low as those which are generally present in ...The sodium trans- verse relaxation time of the phantom must be longer than its ...
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Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene
... peak currents but strongly decreased persistent currents in all mutants tested ...of persistent currents and stabilization of the recovery from inactivation also at 1 μ M GS967 (data ...
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