Pharmaceutics and Technology

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Lipopeptides for the Fragment Based  Pharmaceutics Design

Lipopeptides for the Fragment Based Pharmaceutics Design

This paper describes the synthesis of peptide fragments for use in a new type of combinatorial discovery technology, in which the building blocks are brought together by non-covalent interactions, rather than direct chemical bonding. The building blocks of interest—in this case different amino acids—are converted to amphiphiles by attachment to lipid tails. The amphiphiles, when mixed together in aqueous phase, are designed so that they aggregate spontaneously to form micelles. The building blocks form the headgroups of each of the amphiphiles, and these headgroups cover the surface of the micelle in a dynamic close-packed fluid mosaic array. These building blocks come together so closely that two- or three-dimensional structures are created on the surface of the micelles, and these can be screened in biological assays to find out which combination of building blocks is able to elicit a biological response. Lipopeptides consisting of two residues of lipoamino acid and other amino acids moieties have been designed, synthesized, characterized and the abil- ity of these constructs to form supra-molecular assemblies is demonstrated.
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Evaluation of grewia polysaccharide gum as a suspending agent

Evaluation of grewia polysaccharide gum as a suspending agent

Microsoft Word 2052 docx Research Article EVALUATION OF GREWIA POLYSACCHARIDE GUM AS A SUSPENDING AGENT ELIJAH I NEP1*, BARBARA R CONWAY2 1 Pharmaceutics and Pharmaceutical Technology, Faculty of Phar[.]

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Formulation and Evaluation of Controlled Porosity Osmotic Tablets of Lornoxicam

Formulation and Evaluation of Controlled Porosity Osmotic Tablets of Lornoxicam

Department of Pharmaceutics, Madras Medical College Page 25 27. Deelip Derle et al. 31 developed numerous approaches for solubility enhancement of BCS class II drugs. Various particle engineering processes like super critical fluid technology, cryogenic technology, nanomilling, evaporative precipitation into aqueous solution, melt sono crystallization and cryo ‐ vacuum etc., were developed based on the drug properties and requirement of nanoparticles characters. From the study it was concluded that the use of these processes has improved in vitro dissolution rates and in vivo bioavailability of many poorly water soluble drugs.
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From Scutellaria barbata to BZL101 in Cancer Patients: Phytochemistry, Pharmacology, and Clinical Evidence

From Scutellaria barbata to BZL101 in Cancer Patients: Phytochemistry, Pharmacology, and Clinical Evidence

From Scutellaria barbata to BZL101 in Cancer Patients Phytochemistry, Pharmacology, and Clinical Evidence 1School of Chemical Engineering and Pharmaceutics, Henan University of Science and Technology,[.]

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Nanomechanical sensing of the endothelial cell response to anti-inflammatory action of 1-methylnicotinamide chloride

Nanomechanical sensing of the endothelial cell response to anti-inflammatory action of 1-methylnicotinamide chloride

MNA was kindly provided by Professor Jerzy Gebicki, Lodz University of Technology. Numerous discussions with Professor Stefan Chlopicki are gratefully acknowledged. Nitrite determination using Griess reagents was performed at the Department of Immunology, Jagiellonian University College of Medicine, Krakow, Poland, courtesy of Dr Rafal Biedron. PGI 2 release was measured at the Jagiellonian Center for Experimental Pharmaceutics, Krakow, Poland courtesy of Dr Tomasz Wojcik and Barbara Sitek. This work was supported by the European Union from the resources of the European Regional Development Fund under the Innova- tive Economy Program (grant coordinated by JCET-UJ, No POIG.01.01.02-00-069/09).
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A REVIEW ON LEVOFLOXACIN INSITU GEL

A REVIEW ON LEVOFLOXACIN INSITU GEL

Vol 8, Issue 1, 2015 ISSN 0974 2441 A REVIEW ON LEVOFLOXACIN IN SITU GEL FORMULATION SAXENA ANSHUL*, SINGH RENU Department of Pharmaceutics, Sagar Institute of Technology and Management, Barabanki, Ut[.]

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RECENT APPLICATIONS AND POTENTIALLY ADMINISTER FUTURE PHARMACO THERAPY OF PULMONARY DRUG DELIVERY SYSTEMM. Navya*, Kameswara Rao. SDOWNLOAD/VIEW

RECENT APPLICATIONS AND POTENTIALLY ADMINISTER FUTURE PHARMACO THERAPY OF PULMONARY DRUG DELIVERY SYSTEMM. Navya*, Kameswara Rao. SDOWNLOAD/VIEW

7. Rohan Bhavane, Efstathios Karathanasis, Ananth V. Annapragada, “Agglomerated vesicle technology”: a new classof particles for controlled and modulated pulmonary drug delivery, Journal of Controlled Release 2003;15– 28. 8. Paul J. Atkins and Timothy M. Crowder, Paul J. Atkins and Timothy M. Crowder, “The Design and Development of Inhalation Drug Delivery Systems”, modern pharmaceutics by Marcel Dekker p.1‐31.

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 METHODS OF SIZE REDUCTION AND FACTORS AFFECTING SIZE REDUCTION IN PHARMACEUTICS

 METHODS OF SIZE REDUCTION AND FACTORS AFFECTING SIZE REDUCTION IN PHARMACEUTICS

4. Shekunov Boris Y, Pratibhash Chattopadhyay, Henry HY Tong and Albert HL Chow. Particle Size Analysis in Pharmaceutics: Principles, Methods and Applications. Pharmaceutical Research 2007; 24.2: 203- 27. http://dx.doi.org/10.1007/s11095-006-9146-7 PMid:17191094 5. Snow RH, Kaye BH, Capes CE, Srety GC. Size reduction and size

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3D PRINTING OF PHARMACEUTICALS – A POTENTIAL TECHNOLOGY IN DEVELOPING PERSONALIZED MEDICINE

3D PRINTING OF PHARMACEUTICALS – A POTENTIAL TECHNOLOGY IN DEVELOPING PERSONALIZED MEDICINE

rug delivery is the technology and formulation developed to efficiently transport a pharmacologically active compound in the body to achieve therapeutic efficiency in a safe manner. The efficiency and safety of a pharmaceutical product can be improved by controlling the release profile which in turn modulates the pharmacokinetics of a drug. The inter- species variability is an obstacle frequently faced in the clinical scenario. Customized medicine and dosing receives increasing attention because of the high chances of undesirable side effects. The probability of adverse reactions is higher in the pediatric and geriatric populations when the bulk manufacturing of pharmaceuticals concentrates on the average population (1, 2).
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Formulation and Evaluation of Bilayer Tablets of Losartan Potassium for Immediate Release and Metformin Hydrochloride for Sustained Release

Formulation and Evaluation of Bilayer Tablets of Losartan Potassium for Immediate Release and Metformin Hydrochloride for Sustained Release

Department of Pharmaceutics, Madras Medical College Page 20 immediate release layer using Croscaramellose sodium as superdisintegrant. Nicotinic acid was formulated as sustained release layer using HPMC K100M in varying concentration. 12) Remya PN et al. 23 studied the formulation and evaluation of bilayer tablets of Ibuprofen and Methocarbamol. Wet granulation technique was employed for preparing granules using PVP K 30 as binder. The bilayer tablets were film coated using Advantia prime clear film coat material. Nine batches of bilayer tablets were prepared. The in vitro release of the bilayer tablets were compared with the innovator and the release kinetics of formulation 8 were taken as optimized formulation due to its higher dissolution rate and complied all other parameters with the official specifications.
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Intracellular PD Modelling (PDi) for the Prediction of Clinical Activity of Increased Rifampicin Dosing

Intracellular PD Modelling (PDi) for the Prediction of Clinical Activity of Increased Rifampicin Dosing

Intracellular PD Modelling (PDi) for the Prediction of Clinical Activity of Increased Rifampicin Dosing pharmaceutics Communication Intracellular PD Modelling (PDi) for the Prediction of Clinical Acti[.]

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HYDROTROPIC SOLUBILIZATION: A PROMISING TECHNIQUE TO ENHANCE SOLUBILITY OF POORLY WATER SOLUBLE DRUG LUMEFANTRINE

HYDROTROPIC SOLUBILIZATION: A PROMISING TECHNIQUE TO ENHANCE SOLUBILITY OF POORLY WATER SOLUBLE DRUG LUMEFANTRINE

The solubility studies revealed that the solubility of drug was increased more than 30 folds when added to 30% Tri sodium citrate dihydrate solution and marked its importance in pharmaceutical field. ACKNOWLEDGEMENT: The authors are grateful to Department of Pharmaceutics, Swami Vivekanand College of Pharmacy for providing the facilities to perform research work and they also declare that they have no conflict of interest.

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FORMULATION AND PHYSICOCHEMICAL EVALUATION OF MEDLAR (MESPILUS GERMANICA L ) AND OAK (QUERCUS CASTANEIFOLIA C  A  MEY ) EFFERVESCENT TABLETS

FORMULATION AND PHYSICOCHEMICAL EVALUATION OF MEDLAR (MESPILUS GERMANICA L ) AND OAK (QUERCUS CASTANEIFOLIA C A MEY ) EFFERVESCENT TABLETS

ACKNOWLEDGEMENT: This study was supported by Mazandaran University of Medical Sciences in Sari, Iran with grant number 91 - 126. We would like to thank laboratory personnel of department of Pharmacognosy and Department of Pharmaceutics in faculty of pharmacy of Mazandaran University of Medical Sciences. We also thank Prof. Mohammad Azadbakht, Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences in Sari, Iran for approving the authenticity of the plant used in the research.

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SAFETY AND EFFICACY- DILEMMA OF CURRENT DAY AYURVEDA .......

SAFETY AND EFFICACY- DILEMMA OF CURRENT DAY AYURVEDA .......

like academics, clinical practice, pharmaceutics and researches being studied; one very terrifying yet most important question arises in any sensible Ayurvedic student’s mind whether really the current day Ay- urveda (Ayurvedic practice) is Safe and Effective or Not? So the fact that remains with us is that, though Ayurveda is great with its treasured principles; but the world today does not seem to have enough faith in Ayurveda and its practice. While saying so, one thing should be taken into consideration that over a long period of time some genuine, sincere and intelligent Ayurvedacharyas had been working on the same by deciphering the correct meaning out of the verses written in the ancient Ayurvedic samhitas (Classical textbook). But for any work to get noticed by the world there require a huge amount of research work by collecting more evident Data. Thus now this is a need of time that all the Ayuvedic students and profes- sors, practitioners and researchers should now focus on the betterment of Ayurveda in the sense of its Safety and Efficacy.
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Evaluation of the wound healing activity of gel formulations of leaf extract of Aspila africana Fam  Compositae

Evaluation of the wound healing activity of gel formulations of leaf extract of Aspila africana Fam Compositae

Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria 2 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Ph[r]

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CONTROLLED DRUG DELIVERY SYSTEM: A REVIEWPatel Nidhi*, Chaudhary Anamika, Soni Twinkle, Sambyal Mehul1, Jain Hitesh, Upadhyay UmeshDOWNLOAD/VIEW

CONTROLLED DRUG DELIVERY SYSTEM: A REVIEWPatel Nidhi*, Chaudhary Anamika, Soni Twinkle, Sambyal Mehul1, Jain Hitesh, Upadhyay UmeshDOWNLOAD/VIEW

Oral drug delivery is the most convenient option as the oral route provides maximum active surface area among all drug delivery system for administration of various drugs. The attractiveness of these dosage forms is due to awareness to toxicity and ineffectiveness to drugs when administered by oral conventional method in the form of tablets and capsules. An appropriately designed controlled release drug delivery system can be a major advance towards solving problems concerning the targeting of a drug to a specific organ or tissue and controlling the rate of drug delivery to the target site. Oral Sustained release (SR) / Controlled release (CR) products provide an advantage over conventional dosage forms by optimizing bio-pharmaceutics, pharmacokinetic and pharmacodynamics properties of drugs in such a way that it reduces dosing frequency to an extent that once daily dose is sufficient for therapeutic management through uniform plasma concentration providing maximum utility of drug with reduction in local and systemic side effects and cure or control condition in shortest possible time by smallest quantity of drug to assure greater patient compliance. The present article contains brief review on various formulation approaches for controlled release drug delivery system.
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Formulation and Evaluation of Proniosome Based Niosome of Bosentan Monohydrate Fororal Delivery

Formulation and Evaluation of Proniosome Based Niosome of Bosentan Monohydrate Fororal Delivery

In this method emulsion of aqueous phase is organic solvent containing lipid is prepared by sonication, followed by evaporation of organic Department of Pharmaceutics 29 JKKMMRF College [r]

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Pharmaceutical characterization of novel tenofovir liposomal formulations for enhanced oral drug delivery: in vitro pharmaceutics and Caco-2 permeability investigations

Pharmaceutical characterization of novel tenofovir liposomal formulations for enhanced oral drug delivery: in vitro pharmaceutics and Caco-2 permeability investigations

The validated method was used as a pharmaceutics tool to determine the efficiency and capacity of the liposomal formula- tion to entrap tenofovir. It was also used as a biopharmaceutics tool to analyze samples from the Caco-2 permeability study and assess the potential for oral bioavailability enhancement. Indirect determination of the EF was done by collecting the supernatant of each formulation, following the centrifugation cycle. Each sample was diluted with mobile phase and injected onto the HPLC using the described validated method. Rep- resentative chromatograms of supernatant analysis for teno- fovir liposomal formulations A and B are shown in Figure 2. The chromatograms showed that there was no interference from the liposomal components with the drug peaks. Table 4 shows the capacity of the proposed liposomal formulations to entrap tenofovir base as a function of the incorporated levels of stearylamine. It is important to note that tenofovir entrap- ment was very low in the absence of stearylamine, due to its leakage through the lipid bilayers during hydration of the lipid phase. The obtained data show that increasing stearylamine level was accompanied by an increase in EF. For example, 39% and 68% were the EFs for formulations A and B, which were prepared with 7.5% and 15% (w/w) stearylamine, respectively. This result could be attributed to the ionization of tenofovir into its negatively charged conjugated acid that may interact with the positive stearylamine component of the lipid bilay- ers. 27,35 Deleers et al 36 stated a rigidization of the liposome
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PHARMACEUTICS & THERAPEUTICS OF KAJJALI (BLACK SULPHIDE OF MERCURY) - A REVIEW

PHARMACEUTICS & THERAPEUTICS OF KAJJALI (BLACK SULPHIDE OF MERCURY) - A REVIEW

Trituration of purified Mercury and Sulphur till formation of black powder ( Kajal ) is called Kajjalika.. Kajjali was firstly used in.[r]

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The topography of simulated intestinal equilibrium solubility

The topography of simulated intestinal equilibrium solubility

Article Molecular Pharmaceutics within the matrix are presented as box and whisker plots grouped by pH and total amphiphile concentration along with reported literature solubility values[r]

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