Philadelphia Chromosome Positive
ATG7 regulates energy metabolism, differentiation and survival of Philadelphia chromosome-positive cells
... mitochondrial respiration by oxygen consumption rate (OCR) we observed a signi fi cant increase in the basal, ATP-linked (basal minus oligomycin-treated cells) and maximal OCR in shATG7-expressing cells (Fig. 3B; S3A), ...
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FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphocytic leukemia
... and Philadelphia chromosome–positive (Ph1-positive) acute lymphocytic leukemia (ALL) are 2 fatal BCR/ABL-driven leukemias against which Abl kinase inhibi- tors fail to induce a long-term ...
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Philadelphia chromosome positive AML arising from JAK2-positive myelofibrosis
... a Philadelphia chromosome positive acute myeloid leukemia, detecting the cytogenetic aberration; t(9;22)(q34;q22) encoding the rare BCR-ABL1 fusion gene; ...to Philadelphia chromosome ...
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Treatment and monitoring of Philadelphia chromosome-positive leukemia patients: recent advances and remaining challenges
... +: Philadelphia chromosome-positive; RIC: Reduced-intensity conditioning; RQ-PCR: Real-time quantitative reverse transcription-polymerase chain reac- tion; SCT: Stem cell transplantation; TFR: ...
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A novel <em>BCR-ABL1</em> mutation in a patient with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia
... Abstract: Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) represents the most common genetic subtype of adult ALL (20%–30%) and accounts for approximately 50% of all cases in ...
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Combination therapy with copanlisib and ABL tyrosine kinase inhibitors against Philadelphia chromosome-positive resistant cells
... ABL tyrosine kinase inhibitor (TKI) therapy has improved the survival of patients with Philadelphia (Ph) chromosome-positive leukemia. However, ABL TKIs cannot eradicate leukemia stem cells. ...
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Favorable outcome of haploidentical hematopoietic stem cell transplantation in Philadelphia chromosome-positive acute lymphoblastic leukemia: a multicenter study in Southwest China
... the Philadelphia (Ph) chromosome [1]. Ph-positive ALL (Ph+ ALL) is a high-risk subset of ALL that is associated with a lower probability of complete remission (CR) than Ph-negative ALL (Ph− ALL) and ...
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Breakpoints on chromosomes 9 and 22 in Philadelphia chromosome positive chronic myelogenous leukemia (CML) Amplification of rearranged c abl oncogenes in CML blast crisis
... 20 Philadelphia chromosome (Ph1) positive chronic myelogenous leukemia (CML) samples by Southern blot hybridization to determine the location of the breakpoints that occur on chromosomes 9 and 22 in ...
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Spotlight on ponatinib in the treatment of chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia: patient selection and perspectives
... In addition, the role of ponatinib in elderly patients has not been completely elucidated. Since old age has been described as an independent predictor of high cardiovascular risk, ponatinib may not be well tolerated by ...
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Correlation between deletion of the CDKN2 gene and tyrosine kinase inhibitor resistance in adult Philadelphia chromosome-positive acute lymphoblastic leukemia
... Results from the current study revealed that a shorter survival time and a higher recurrence rate was observed in Ph-positive ALL patients with CDKN2 deletion. Previ- ous studies reported similar poor survival as ...
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Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells
... Cell shrinkage and induction of autophagy was confirmed also in the CML lymphoid BC cell line BV173, which was chosen because of the slow kinetics of cell death induction upon IM treatment. May-Grünwald staining and FACS ...
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Ruxolitinib/nilotinib cotreatment inhibits leukemia propagating cells in Philadelphia chromosome positive ALL
... University Institute of Hematology from January 1, 2015 to May 31, 2015 were enrolled for this in vitro and in vivo study. The patient clinical characteristics are shown in Table 1. The inclusion criteria were (1) 18–60 ...
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Update on the management of Philadelphia chromosome positive chronic myelogenous leukemia: role of nilotinib
... Abstract: Chronic myelogenous leukemia (CML) is a pluripotent stem cell disease characterized by the presence of the Philadelphia chromosome and the bcr-abl gene. The discovery of tyrosine kinase inhibitors ...
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The molecular detection of circulating tumour cells
... Detection of Philadelphia chromosome-positive acute lymphoblastic leukemia by polymerase chain reaction - possible eradication of minimal residual disease by marrow transplantation.. MOE[r] ...
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Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation
... We report the successful treatment and sustained molecular remission using single agent nilotinib in a relapsed Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia patient after ...
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Potential of ponatinib to treat chronic myeloid leukemia and acute lymphoblastic leukemia
... Abstract: Development of BCR-ABL tyrosine kinase inhibitors (TKIs) have improved outcomes for patients diagnosed with chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic ...
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Clinical trial update on bispecific antibodies, antibody-drug conjugates, and antibody-containing regimens for acute lymphoblastic leukemia
... for Philadelphia chromosome-positive ALL, immunotherapeutic agents, blinatumomab, inotuzumab ozogamicin (INO), and chimeric antigen receptor (CAR) T cells, are changing the treatment paradigm for ...
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Extramedullary relapse of acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation treated by CAR T-cell therapy: a case report
... Abstract: Philadelphia chromosome-positive (Ph-positive) acute leukemia (ALL) accounts for around one quarter of adult cases of ALL and is usually associated with poor ...
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PHILADELPHIA CHROMOSOME IN PRETHERAPEUTIC CASES OF CHRONIC MYELOGENOUS LEUKEMIA
... had philadelphia chromosome positive. In philadelphia negative group 2(11%) patients had ...though philadelphia chromosome is very much popular and essential for the diagnosis of ...
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Neurological Complications of Myeloproliferative Syndromes with Negative Philadelphia Chromosome (MPS Ph-) in Lome Tertiary Hospital
... Komi Assogba, Kodzo Vinyo Kumako, Kossivi Martin Apetse, Essohana Justin Padaro, Abago Balaka, Abdoullaye Idrissou, Komi Igneza Agbotsou, Nyenèvi Komla Anayo, Abdullah Blakime, Agnon Ayélola Koffi Balogou. Neurological ...
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