p38 phosphorylation does not regulate an N-terminal / 14-3-3β interaction
14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila
... both 14-3-3 and Tsc2 are much smaller than the normal size of 14-3-3 RNAi ...how 14-3-3 RNAi negatively affects wing tissues under Rheb overexpression or ...
11
N-Terminal Phosphorylation Sites of Herpes Simplex Virus 1 ICP0 Differentially Regulate Its Activities and Enhance Viral Replication
... its interaction with one of its substrates, USP-7 ...finding does not exclude the possibility that phosphorylation in region I can affect the binding of ICP0 to other target substrates, it suggests ...
11
Distinct phosphorylation requirements regulate cortactin activation by TirEPEC and its binding to N-WASP
... the N-terminal moiety of cortactin, since our pre- vious studies indicated that phosphorylation of cortactin affects mainly its interaction with partners through the SH3 domain ...the ...
14
Human 14-3-3 Paralogs Differences Uncovered by CrossTalk of Phosphorylation and Lysine Acetylation
... Because 14-3-3 interaction networks are obviously enriched in phosphorylation, and kinases networks were intentionally added, we highlighted with small stars on the Cytoscape graphs ...
16
Interaction between haemoglobin and synthetic peptides of the N terminal cytoplasmic fragment of trout band 3 (AE1) protein
... an interaction between band 3 peptides and trout Hb could not be established in vitro, this does not exclude an interaction between Hb and band 3 in intact fish red blood ...band ...
6
Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localisation of polycystin-2 in vivo and in vitro
... 2Department of Medicine, Metrohealth Medical Center, Case Western Reserve University, Cleveland, USA Abstract PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2 ...
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14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins
... the N termi- nus and five near the C terminus (Riento et ...endogenous 14-3-3 proteins in cells (Fig- ures S1C and S1E), indicating that at least one of these residues is involved in the ...
14
The Role of the Tau N-Terminal Phosphatase-Activating Domain and Phosphorylation at Thr175 in the Formation of Tau Cytoplasmic Inclusions
... what regulate the targets activity of the enzyme ...aberrant phosphorylation of tau and the development of fibrils, as demonstrated in Experimental Set ...
152
The Complex Phosphorylation Patterns That Regulate the Activity of Hsp70 and Its Cochaperones
... the interaction with residues Glu268 and Arg272 that participate in the correct positioning of the substrate [ 71 ...]. Phosphorylation of loops L1,2 and L3,4 around the peptide binding site at the SBDβ ...
25
A Redundant Function for the N-Terminal Tail of Ndc80 in Kinetochore–Microtubule Interaction in Saccharomyces cerevisiae
... extended N-terminal tail that varies among different species in both length and sequence but is highly positively charged in all ...The N-terminal tail is unstructured and not present in the ...
9
PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation
... PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation Hongge Jia, Yajuan Liu, Wei Yan and Jianhang Jia* The seven-transmembrane protein Smoothened (Smo) and Zn-finger transcription ...
10
Mps1 phosphorylation sites regulate the function of Centrin 2 in centriole assembly
... Cetn2 can organize distal centriole elements in the absence of extra cartwheels, just as phage heads can be assembled in the absence of phage tails and vice versa (Wood, 1980). In support of this idea, depletion of ...
41
Structural Basis for the Interaction of 14 3 3β with Tricarboxylic Acid Cycle Intermediate Malate
... mammalian 14-3-3β protein in its apo and a Tricarboxylic Acid Cycle intermediate Malte bound ...metabolite interaction with 14-3-3β, the work provides a structural frame ...
12
Serine 3 is critical for phosphorylation at the N-terminal end of the nucleoprotein of influenza virus A/Victoria/3/75.
... vivo phosphorylation site(s) of this protein, 32 P-labeled NP was purified from cell cultures infected with influenza virus A/Victoria/3/75 by immunoaffinity ...the N-terminal 88 amino acids ...
7
Controllability of protein-protein interaction phosphorylation-based networks: Participation of the hub 14-3-3 protein family
... 10 3 –10 6 folds stronger affinities than domains-linear motif interactions ...in phosphorylation, the central post-translational modification (PTM) in most signaling networks, it is clear an enrichment in ...
11
Regulation of dematin by the p38 MAPK and the adaptor protein 14 3 3
... under p38 hyper-activated conditions, however this does not confirm that they are directly phosphorylated by ...activate p38, and cells co-transfected with MKK6 DD and treated with SB203580 to ...
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Interaction of hookworm 14 3 3 with the forkhead transcription factor DAF 16 requires intact Akt phosphorylation sites
... hookworm 14-3-3 proteins play a similar role in L3 activation, hookworm FTT-2 was identified and tested for its ability to interact with ...human 14-3-3β ...This ...
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Phosphorylation Properties of the N Terminal Region of Twitchin from Molluscan Catch Muscle
... tein phosphorylation by retarding the mobility of phosphorylated proteins compared to their unphosphorylated ...these phosphorylation sites D1-1 (origi- nally DX), D1-2, D1-3, and D1-4 (originally ...
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14 3 3β protein expression in eosinophilic meningitis caused by Angiostrongylus cantonensis infection
... of 14-3-3 proteins in CSF of patients afflicted with a wide range of neuro-degenerative dis- eases has been well documented [17,26], however there is few literatures which discuss the presence of ...
9
14-3-3 Proteins: Active Cofactors in Cellular Regulation by Serine/Threonine Phosphorylation
... of 14-3-3 in cellular regulation have fo- cused on changes in target protein phosphorylation as the initiating regulatory event, viewing the 14-3-3 polypeptide as the ...
6