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Physiological Changes: Stem Cells

Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging

Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging

... Neurogenesis in the adult DG is a multistep process dynami- cally regulated by several factors ( Jessberger and Gage, 2008; Zhao et al., 2008 ). Each of these modulators may act at one or multiple levels of the ...

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GSK3β regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement

GSK3β regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement

... the changes in total GSK3β levels, whereas the levels of pS9-GSK3β ...these changes in GSK3β expression were observed as soon as 20 minutes after adrenergic stimulation with NE, but not after 1 hour, when ...

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Hypoxia and neural stem cells: from invertebrates to brain cancer stem cells

Hypoxia and neural stem cells: from invertebrates to brain cancer stem cells

... the cells of the nervous system are capable of sensing changes in oxygen tension, and oxygen changes have complex but poorly understood effects on precur- VRU FHOO IDWH LQ ERWK PXULQH DQG KXPDQ ...

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Adipogenesis of adipose-derived stem cells may be regulated via the cytoskeleton at physiological oxygen levels in vitro

Adipogenesis of adipose-derived stem cells may be regulated via the cytoskeleton at physiological oxygen levels in vitro

... and physiological oxygen levels on ASCs has not been previously ...C3H10T1/2 cells, an immortalized MSC line ...these changes in vitro through the use of chemical inhibitors that target intracellular ...

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Epidermal stem cells in physiological tissue regeneration, wound healing and cancer

Epidermal stem cells in physiological tissue regeneration, wound healing and cancer

... recruited cells and releases various growth factors and other signalling molecules ...immune cells appear at the wound ...the cells regenerating the new tissue invade the ...

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Conversion of Stem Cells to Cancer Stem Cells: Undercurrent of Cancer Initiation

Conversion of Stem Cells to Cancer Stem Cells: Undercurrent of Cancer Initiation

... of cells, including CSCs [ 100 ...KLM1 cells [ 87 ...miPS-PK8cm cells and miPS-KLM1cm cells generated tumors in 9 out of 9 mice for each cell line, indicating tumorigenic ...miPS-KLM1cm ...

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Cancerous stem cells: deviant stem cells with cancer-causing misbehavior

Cancerous stem cells: deviant stem cells with cancer-causing misbehavior

... both in DNA mismatch repair mechanisms, including MSH2 and MLH1, which can lead to loose control of DNA metabolism and cell cycle control and result in carcinogenesis [56,57]. Th is results in a nucleotide mutation rate ...

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Characterization of Embryonic Stem Cell-Differentiated Cells as Mesenchymal Stem Cells

Characterization of Embryonic Stem Cell-Differentiated Cells as Mesenchymal Stem Cells

... contain cells that are anchorage- ...dish. Cells such as these require specific attachment factors such as collagen or gelatin, which are used to coat cell culture dishes and allow for better ...the ...

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The Physiological Changes in Pregnancy and their Distribution According to Trimester

The Physiological Changes in Pregnancy and their Distribution According to Trimester

... skin changes of pregnancy with respect to the ...observed physiological skin changes in order were hyperpigmentation in 311 patients (71%), hypertrichosis in 124 patients (31%), hypothricosis in 15 ...

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Anatomical and Physiological Changes in Pregnancy Relevant to Anaesthesia

Anatomical and Physiological Changes in Pregnancy Relevant to Anaesthesia

... The principle hormone of pregnancy is progesterone. Soon after fertilisation, the developing placenta produces human chorionic gonadotropin (hCG). This sustains the corpus luteum until the 6 th to 8 th week of pregnancy ...

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Role of stem cells in cancer therapy and cancer stem cells: a review

Role of stem cells in cancer therapy and cancer stem cells: a review

... of stem cells as delivery vehicles came from the fact that the tumours, similar to the wounds, send out chemo-attractants such as the vascular endothelial growth factor (VEGF) to recruit MSC to form the ...

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Serial changes in the proliferation and differentiation of adipose-derived stem cells after ionizing radiation

Serial changes in the proliferation and differentiation of adipose-derived stem cells after ionizing radiation

... ASCs are important to the homeostasis and repair of tissues in which they are found. Additionally, ASCs pos- sess various functions as progenitor cells and differenti- ate into adipocytes, osteoblasts, and ...

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Influences of age-related changes in mesenchymal stem cells on macrophages during in-vitro culture

Influences of age-related changes in mesenchymal stem cells on macrophages during in-vitro culture

... phenotype cells upreg- ulate activities related to tissue destruction via secretion of numerous proinflammatory cytokines, such as tumor ne- crosis factor alpha (TNFα), interleukin-1β (IL-1β), interleukin-12 ...

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Stem cells and haemopoiesis

Stem cells and haemopoiesis

... of stem cell ...marrow cells in gene knockout, knockin and gene transfer ...progenitor cells and the size of the stem cell pool; the Fas and Fas ligand genes, which generally are associated ...

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Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence

Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence

... plasma cells) shown in Figure 5B and Supplementary Table ...senescent cells upon similar treatment (Figure 5B and Supplementary Table ...SR cells by transcriptional down-regulation of the genes ...

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LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

... that changes in H4K16ac level at given loci are indeed detected upon HSC aging and rejuven- ation, we also wanted to test whether a change in the position of H4K16ac-associated genomic regions might contribute to ...

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Modulatory Effects of Human Bone Marrow-Derived
Mesenchymal Stem Cells on Proliferation and
Ultrastructural Changes in K562 Leukemic Cells

Modulatory Effects of Human Bone Marrow-Derived Mesenchymal Stem Cells on Proliferation and Ultrastructural Changes in K562 Leukemic Cells

... K562 cells are co- cultured with hBM-MSCs should be ...1600 cells/mL have been able to substantially increase the viability of K562 ...K562 cells and hBM- MSCs, it is plausible to hypothesize that ...

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Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?

Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?

... differentiated cells in vivo in a leporine and canine model, respectively, and found that these cells in- corporated into the host tissue, functioned as osteoblasts and resided in situ for at least 28 days ...

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Comparative Biology of Glioma Stem Cells and Embryonic Neural Stem Cells in Dogs.

Comparative Biology of Glioma Stem Cells and Embryonic Neural Stem Cells in Dogs.

... xenograft-derived cells, and without pre-selection of any putative GSC subpopulations, implies that the relationship between the percentage of GSC per tumor, tumor latency and degree of malignancy is an inherent ...

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Hematopoietic Stem Cells

Hematopoietic Stem Cells

... similar stem cell ...hematopoietic stem cell recipients with the idea in mind that this may actually help to process hematopoietic stem cells from the donor graft and help with the development ...

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