PIGMENT EPITHELIUM
Osteogenic Effects of Pigment Epithelium Derived Factor on Mesenchymal Stem Cells
... 51 evolution [187]. It is a protein of 418 amino acids, with a size of 50kDa and is widely expressed in most bodily tissues [188]. The highest amount of expression has been observed in the eye, foetal and adult liver, ...
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OX40 ligand expression abrogates the immunosuppressive function of retinal pigment epithelium
... retinal pigment epithelium (RPE)-mediated suppression of T cell activation [27], induction of apoptosis of activated T cells via Fas-FasL interactions [28], and inhibition of T cell proliferation by a ...
7
Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium
... retinal pigment epithelium (RPE) is a single-cell thick epithelium located at the posterior of the eye, apposed between the neural retina and the choroidal ...
10
Serum pigment epithelium-derived factor levels are independently correlated with the presence of coronary artery disease
... : Serum pigment epithelium-derived factor levels are independently correlated with the presence of coronary artery disease. Cardiovascular Diabetology 2013 12 :56[r] ...
8
Conditional inhibition of screening pigment aggregation by lidocaine in crayfish photoreceptors and frog retinal pigment epithelium
... CONDITIONAL INHIBITION OF SCREENING-PIGMENT AGGREGATION BY LIDOCAINE IN CRAYFISH PHOTORECEPTORS AND FROG RETINAL PIGMENT EPITHELIUM BY RICARDO MONDRAG6N AND EUGENIO FRIXIONE* Departament[r] ...
18
A strategy to ensure safety of stem cell-derived retinal pigment epithelium cells
... retinal pigment epithelium (RPE) for the treatment of age-related macular degeneration, we present a novel strategy for ensuring the absence of stem cells in the RPE ...
8
The effects of pigment epithelium-derived factor on atherosclerosis: putative mechanisms of the process
... ACS: Acute coronary syndrome; AGE: Advanced glycation end product; AMI: Acute myocardial infarction; AMPK: AMP-activated protein kinase; ATGL: Adipose triglyceride lipase; ATP: Adenosine triphosphate; BNP: Brain ...
11
Formation of retinal pigment epithelium in vitro by transdifferentiation of neural retina cells
... Pritchard (1981) observed that multilayers are produced by the upward extrusion of cells due to their continuing expansion in packed areas to the extent that a cell or group of cells is “pushed” upwards. We have seen ...
10
Elevated plasma levels of pigment epithelium-derived factor correlated with inflammation and lung function in COPD patients
... of pigment epithelium-derived factor (PeDF) in the plasma from the healthy nonsmokers group, healthy smokers group, and chronic obstructive pulmonary disease (COPD) ...
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In Vitro Differentiation of Human Bone Marrow Stem Cells into Retinal Pigment Epithelium
... retinal pigment epithelium (RPE), a monolayer of cells between the neural retina and the choriocapillaris, is the main player in the maintenance and function of the retina and its ...visual pigment ...
5
Identification of Pigment Epithelium-Derived Factor as an Adipocyte-Derived Inflammatory Factor
... It has been proposed that PEDF medi- ates its diverse biological functions by binding to different cell surface recep- tors, namely ATGL (also known as cal- cium independent PLA2/iPLA2) and LR (19,20). Using yeast ...
8
Circulating levels and subcutaneous adipose tissue gene expression of pigment epithelium-derived factor in polycystic ovary syndrome and normal women: a case control study
... Reverse transcription of 1 μg of total RNA into cDNA was carried out using the Superscript II First-Strand Synthesis System for RT-PCR (Invitrogen™ Life Technologies, Foster City, CA, USA), according to manufacturer ...
7
Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration
... AMD: age-related macular degeneration; CHO: choroid; CK18: kertain18; DIC: Digital Image Correlation; ERG: Electroretinograph; INL: inner nuclear layer; LRAT: lecithin retinol acyltransferase; IS: inner segment; MERTK: ...
11
Notes on the Distribution of Pigment Granules in the Retinal Pigment Epithelium of Light and Dark Adapted Rana Temporaria, and on the Nature of the Eye Pigment in the Frog and the Ox
... DISCUSSION The main observations which have been made concerning the distribution of pigment granules in the retinal pigment epithelium of frogs following treatment with light or darknes[r] ...
11
Development of a blood retina barrier on a chip with human iPSC derived retinal pigment epithelium and endothelium
... retinal pigment epithelium (RPE), Bruch’s membrane (BrM), and the choriocapillaris (CC), which altogether compose the outer blood-retina barrier (oBRB) (Figure ...
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Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia
... Choroideremia (CHM) is an X-linked degeneration of the retinal pigment epithelium (RPE), photoreceptors, and choroid, caused by loss of function of the CHM/REP1 gene. REP1 is involved in lipid modification ...
10
Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins
... To better understand the role of Prpf31 in retinal degen- eration, we have used heterozygous Prpf31 A216P/+ KI mice (Bujakowska et al., 2009), a mouse model which carries the point-mutation p.A216P in the Prpf31 gene, ...
22
Proteomic analysis of retinal pigment epithelium cells after exposure to UVA radiation
... The first group of proteins identified was involved in the stress response, cell proliferation, and apoptosis, including peroxiredoxin-1 (PRDX1), heat-shock protein 27 (Hsp27), protein d[r] ...
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mTOR mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice
... Retinal pigment epithelial (RPE) cell dysfunction plays a central role in various retinal degenerative diseases, but knowledge is limited regarding the pathways responsible for adult RPE stress responses in ...
16
Expression and permeation properties of the K + channel Kir7 1 in the retinal pigment epithelium
... In numerous recordings from cell-attached patches of apical membrane on isolated bovine RPE cells, however, we failed to record unitary currents that could be attributed to a Kir channel[r] ...
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