PK, protein kinase
The Herpes Simplex Virus Type 2 R1 Protein Kinase (ICP10 PK) Functions as a Dominant Regulator of Apoptosis in Hippocampal Neurons Involving Activation of the ERK Survival Pathway and Upregulation of the Antiapoptotic Protein Bag-1
... the protein kinase activity of the large subunit of the HSV-2 ribonucleotide reductase (R1) protein (ICP10 PK) blocks apoptosis in cultured hippocampal neurons by activating the extracellular ...
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The Epstein-Barr Virus (EBV)-Encoded Protein Kinase, EBV-PK, but Not the Thymidine Kinase (EBV-TK), Is Required for Ganciclovir and Acyclovir Inhibition of Lytic Viral Production
... thymidine kinase in HSV-infected cells (20) but mediated by the viral protein kinase (UL97) in HCMV-infected cells (53, ...polynucleoside kinase, UL97 is not known to be a nucleoside ...
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Na+,K+-ATPase Phosphorylation in the Choroid Plexus: Synergistic Regulation by Serotonin/Protein Kinase C and Isoproterenol/cAMP-PK/PP-1 Pathways
... roid plexuses incubated with serotonin alone (Fig. 4C), serotonin plus okadaic acid (Fig. 4D), or serotonin plus forskolin (Fig. 4E) generates radioactive peptides that are present in th[r] ...
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Induction of H2AX phosphorylation in tumor cells by gossypol acetic acid is mediated by phosphatidylinositol 3-kinase (PI3K) family
... dependent protein kinase (DNA-PK) –proficient and -deficient cells, the two human malignant glioma cell lines M059K and M059J, isolated and established by Allalunis-Turner et ...
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Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway
... Protein kinase CK2 (thereafter called CK2) is a pleiotro- pic serine/threonine PK, with over 300 substrates identi- fied in mammalian cells [10] and documented roles in multiple cellular processes, ...
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Specificity and localization of the hepatitis B virus-associated protein kinase.
... Recently, a protein kinase PK was detected in purified preparations of core particles from virus or from liver; this enzyme phosphorylates the major core protein in vitro 1.. It is not y[r] ...
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Advances in using PARP inhibitors to treat cancer
... DNA protein kinase (DNA PK) complex [Ku70, Ku80, DNA PK] involved in NHEJ of DSBs; and the epigenetic regulation of chromatin structure ...
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Increased non-homologous end joining makes DNA-PK a promising target for therapeutic intervention in uveal melanoma
... pathway protein DNA-dependent protein kinase (DNA-PK) was measured by analysing the foci formation and the ligation efficiency by NHEJ determined using a plasmid-based end-joining ...NHEJ ...
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Multiple roles and therapeutic implications of Akt signaling in cancer
... 4E-binding protein 1; AGC, protein kinase A/protein kinase G/protein kinase C-like; Bcl-2, B-cell lymphoma 2; CAP, catabolite activator protein; CTMP, ...
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DNA-PK Deficiency in Alzheimer's Disease
... mutated protein; BER: base excision repair; DNA-PK: DNA- dependent protein kinase; DSB: double strand breaks; DSBR: Double strand break repair; HR: Homologous recombination; NER: Nucleotide ...
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EFFECT OF ETHANOL EXTRACT OF TRACHYSPERMUM AMMI ON PYRUVATE KINASE AND PHOSPHOENOLPYRUVATE CARBOXYKINASE OF COTYLOPHORON COTYLOPHORUM
... Carbohydrate metabolism in parasites plays an important role in its adaptation and survival in mammalian host. The major difference between carbohydrate catabolism of parasites and the host was acetyl-CoA, which plays ...
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Screening of potential diagnostic markers and therapeutic targets against colorectal cancer
... Results: Totally, 2,284 and 1,142 genes were predicted to have aberrant promoter hyperm- ethylation or hypomethylation, respectively. MAP3K5, MAP3K8, MAPK14, and MAPK9 with promoter hypermethylation functioned via MAPK ...
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From mouth to macrophage: mechanisms of innate immune subversion by Mycobacterium avium subsp. paratuberculosis
... signal-regulating kinase 1; AP-1-Jun: Activator protein-1-JUN; ATP: Adenosine triphosphate; BCG: Bacillus Calmette-Guerin; Bcl-2: B-cell lymphoma 2; CARD15: Caspase associated recruitment domain 15; CD4+: ...
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Kinase Activity Profiling of Gram-Negative Pneumonia
... ing kinase activity during progressive Gram-negative pneumonia (Figure ...hydrogenase kinase (PDK) (19) (spot 934) and via GSK-3β (spots 84, 443 and 1020) (20) and tuberin (spot 373) signals to- ward ...
7
The role of Feronia in regulating growth and development in Arabidopsis thaliana roots
... Despite the multiple controls the RIC1-MBP affinity enrichments proved to be very variable and had very little reproducibility between samples after NAA and RALF1 treatment, with many western blots showing fluctuating ...
356
p53: key conductor of all anti acne therapies
... ing protein-1c (SREBP1c) and peroxisome proliferator- activated receptor-γ (PPARγ) ...anti-apoptotic protein survivin [24, 25], which has recently been found to be upregulated in the skin of acne patients ...
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Mitogen-Activated Protein Kinase-Activated Kinase RSK2 Plays a Role in Innate Immune Responses to Influenza Virus Infection
... In contrast to the above-mentioned studies, which found a virus-supportive role for RSK2, our findings suggest an antivi- ral activity for this kinase. In particular, we found that the C-terminal domain of RSK2, ...
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Activation of mTOR: a culprit of Alzheimer’s disease?
... p53 (protein 53 or tumor protein 53) is a tumor suppressor protein that plays a major role in preventing tumor develop- ment. It responds to a range of potentially oncogenic stresses by activating ...
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Alteration of parameters of energy metabolism and ATPase enzymatic system in juvenile common carp (Cyprinus carpio) chronically exposed to tributyltin
... The parameters of energy metabolism in muscle tissue of common carp are summarized in Table 1. There was no significant change in Glu and LA lev- els in fish tissues in E1 group when compared with the control. However, ...
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Development of a pooled probe method for locating small gene families in a physical map of soybean using stress related paralogues and a BAC minimum tile path
... Each BAC clone that hybridized to an EST and formed part of a separate contig was inferred to contain a paralogue of that gene family. The number of paralogues inferred per EST ranged from 1 to 15 (Table 1) [see ...
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