Plasminogen Activator Inhibitor (PAI)-1
Plasminogen activator inhibitor-1 and cardiovascular risk
... 2.1.3.1. Plasminogen activator inhibitor-1 activity PAI-1 is a plasma protein that rapidly and specifically inhibits t-PA and ...and plasminogen activator binding ...
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Plasminogen activator inhibitor 1 in acute hyperoxic mouse lung injury
... overproduce plasminogen activator inhibitor-1 (PAI-1), and that PAI-1 upregulation impairs fibrinolytic activity in the alveolar ...
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Plasminogen Activator Inhibitor-1 (PAI-1) deficiency predisposes to depression and resistance to treatments
... the Plasminogen Activator Inhibitor-1 (PAI-1) may contribute to ...tissue-type Plasminogen Activator (tPA) – Brain-Derived Neurotrophic Factor (BDNF) axis, but associated ...
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Coordinated induction of plasminogen activator inhibitor 1 (PAI 1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition
... of plasminogen activator inhibitor-1 (PAI-1) antigen, detected by ELISA, increased in a time- dependent fashion after hypoxic exposure (increased as early as 4 h, P < ...tissue-type ...
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Peptide mediated inactivation of recombinant and platelet plasminogen activator inhibitor 1 in vitro
... https://doi.org/10.1172/JCI117937. Plasminogen activator inhibitor-1 (PAI-1), the primary inhibitor of tissue-type plasminogen activator (t-PA) and urokinase ...
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Development and optimization of the methods for determining activity of plasminogen activator inhibitor-1 in plasma
... of plasminogen activator inhibitor-1 (PAI-1) are important indicators of pathological processes, because its content in plasma increases at acute myocardium infarction, tumor, diabetes ...
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Close relationship of tissue plasminogen activator plasminogen activator inhibitor 1 complex with multiple organ dysfunction syndrome investigated by means of the artificial pancreas
... ‡ Department of Emergency and Critical Care Medicine, Chiba University School of Medicine, Chuo-ku, Chiba-shi, Chiba, Japan Correspondence: Masami Hoshino, Department of Intensive and Critical Care Medicine, Tokyo Police ...
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Plasminogen activator inhibitor 1 gene deficient mice I Generation by homologous recombination and characterization
... Homozygous plasminogen activator inhibitor-1 (PAI-1)-deficient (PAI-1-/-) mice were generated by homologous recombination in D3 embryonic stem ...(PAI- 1+/+) but not from ...
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The effects of residual platelets in plasma on plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1-related assays
... degradation). Plasminogen activator inhibitor-1 activ- ity, plasminogen activator inhibitor-1 antigen, tissue plasminogen activator/plasminogen ...
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Association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects
... The plasminogen activator inhibitor-1 -675 4G/5G genotype influences the risk of myocardial infarction associated with elevated plasma proinsulin and insulin concentrations in men from Europe: ...
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Association of plasminogen activator inhibitor 1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects
... The plasminogen activator inhibitor-1 -675 4G/5G genotype influences the risk of myocardial infarction associated with elevated plasma proinsulin and insulin concentrations in men from Europe: ...
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Possible Role of Plasminogen Activator Inhibitor-1 in Childhood Bronchial Asthma
... – Plasminogen activator inhibitor-1 _____________________________________________________________________________________________ INTRODUCTION Asthma represents a chronic inflammatory process ...
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The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans
... tissue plasminogen activator: plasminogen activator inhibitor-1 complex and matrix metalloproteinase-3 are significantly ele- vated in cerebrospinal fluid of trauma patients and ...
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Regulation of urokinase plasminogen activator and plasminogen activator inhibitor-1 in murine breast cancer cells
... determine if this PAR-1-dependent uPA secretory mechanism is applicable to human cell lines. The second novel finding was that thrombin-activated PAR-1 transactivated PAR-2 to induce PAI-1 mRNA and ...
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Effects of pitavastatin on plasminogen activator inhibitor-1 in hyperlipidemic patients
... Statins play a critical role in cholesterol metabolism. 37 Statins also have pleiotropic effects, such as antithrombotic and anti-inflammatory effects. 38 Oxidative stress plays a pivotal role in the pathogenesis of ...
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Usefulness of plasminogen activator inhibitor-1 as a predictive marker of mortality in sepsis
... In sepsis, innate immune responses start following the identification of pathogen-associated molecular patterns or damage-associated molecular patterns by pattern- recognition receptors, such as Toll-like receptors ...
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Tissue Distribution and Regulation of Plasminogen Activator Inhibitor-1 in Obese Mice
... 6-fold) in PAI-1 mRNA expression observed in the epididymal, subcutaneous, and brown fat of the obese mice (Fig. 2) suggests that the adipose tissue itself may be a significant contribut[r] ...
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A Plasminogen Activator Inhibitor-1 Promoter Polymorphism and Idiopathic Interstitial Pneumonia
... technology is being employed to search for disease susceptibility genes by simultaneously determining the genotype at a very large number of polymorphic loci in patients having a particular dis- ease. Statistical ...
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Design, synthesis and evaluation of small molecules as inhibitors of plasminogen activator inhibitor-1
... In addition to natural products, several research studies have reported monoclonal antibodies, peptides, and small molecules as effective PAI-1 inhibitors. 39 Monoclonal antibodies (MA) have become a topic of ...
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Plasminogen activator inhibitor-1 is elevated in patients with COPD independent of metabolic and cardiovascular function
... disorders. 1 Local pathological changes of COPD include parenchymal tissue destruction, resulting in emphysema, and disrupted repair and defense mechanisms, resulting in small airway ...fibrosis. 1 ...
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