Plasminogen activator-plasmin system
The plasminogen activator/plasmin system
... Identification and characterization of human endothelial cell membrane binding sites for tissue plasminogen activa-. tor and urokinase[r] ...
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Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin
... and plasmin in- hibit this avid association implies that under physiological con- ditions uPAR-dependent cellular attachment to vitronectin is likely only ...
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Tissue plasminogen activator (tPA) inhibits plasmin degradation of fibrin A mechanism that slows tPA mediated fibrinolysis but does not require alpha 2 antiplasmin or leakage of intrinsic plasminogen
... a system lacking an extrinsic phase when plasminogen was added to fibrin suspensions preincubated with increasing ...intrinsic plasminogen leakage and alpha 2-antiplasmin were not required for the ...
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Review. The urokinase-type plasminogen activator system and inflammatory joint diseases
... of plasminogen activator and collagenases by rheumatoid and non- rheumatoid synovial cells in culture was subsequently shown (94, ...of plasminogen ac- tivators in the endogenous activation of latent ...
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Plasmin, plasminogen, protein and somatic cells variation of bulk milk
... Sweden. Plasmin (PL), plasminogen (PG), somatic cell count (SCC) and total protein (TP) content were investigated in bulk milk received at the ...milking system and production ...PG activator ...
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Determination of plasminogen/plasmin system components and indicators of lipoproteins oxidative modification under arterial hypertension
... of plasminogen/plasmin system components – tissue-type plasminogen activator (t-pa) and plasminogen activa- tors inhibitor-1 (paI-1), in patients with stage II arterial ...
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Fibrinolysis regulation by platelets retaining plasminogen and tissue-type plasminogen activator on their surface
... of plasminogen and tissue plasminogen activa- tor with native and activated platelets, to determine the amount of plasmin generated by various activators in the presence of platelets, and the ability ...
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Expression and activity of the urokinase plasminogen activator system in canine primary brain tumors
... uPA system consists of the serine proteinases uPA and plasmin, two serpin plasminogen activator inhibi- tors (PAI; PAI-1 and PAI-2), the serpin plasmin inhibitor α 2 ...
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PPAR-[gamma] ligands and adipocytes regulate expression of the plasminogen activator system in breast cancer
... Adipocytes increase cell-surface uPA activity Our lab has previously shown PI3K activity can both upregulate uPA expression and decrease PAI-1 expression. Since uPA activity has been implicated in cell motility, we ...
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The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans
... Tissue plasminogen ac- tivator is a serine protease that converts plasminogen to plasmin, a protease that dissolves blood ...tissue plasminogen activator is abundantly expressed in the ...
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Catabolic Pathways for Streptokinase, Plasmin, and Streptokinase Activator Complex in Mice: IN VIVO REACTION OF PLASMINOGEN ACTIVATOR WITH α2 MACROGLOBULIN
... Steven L. Gonias, … , Monica Einarsson, Salvatore V. Pizzo J Clin Invest. 1982;70(2):412-423. https://doi.org/10.1172/JCI110631. The catabolic pathways of streptokinase, plasmin, and activator complex ...
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Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness
... fibrinolytic system protein balance consistent with promotion of fibrin deposi- tion in mice with allergic airway ...tissue-type plasminogen acti- vator, significantly diminished airway hyperresponsiveness ...
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Regulation of urokinase plasminogen activator and plasminogen activator inhibitor-1 in murine breast cancer cells
... More than a century ago, Armand Trousseau first described an association between cancer and the coagulation system 1,2 . Later it was discovered that tumor cells release procoagulant microvesicles (often referred ...
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Role of plasminogen/plasmin in functional activity of blood cells
... Мы исследовали влия- ние плазминогена на агрегацию тромбоцитов, индуцируемую различными агонистами (АDP, коллаген, тромбин), и показали, что Lys-, но не Glu-плазминоген оказывает инги[r] ...
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Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) in breast cancer
... which functions as a natural inhibitor of uPA, is the most important factor among fibrinolytic inhibi- tors for the development of vascular diseases and cancer. uPA and PAI-1 do not only have proteolytic characteristics, ...
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Tissue-Type Plasminogen Activator, Plasminogen Activator Inhibitor, and Histidine-Rich Glycoproteins in Stressed Human Newborns
... Tissue-type plasminogen activator antigen was determined by an enzyme-linked immuno- sorbent assay (ELISA) method using a commercial kit (Imubind-5- tPA, American Diagnostica).4’9 Plasmi[r] ...
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With the use of tissue plasminogen activator (tpa) for
... the brain stem. Hemispheres and brain stem were cut into five 5-mm-thick coronal slices, each having 2 faces. We noted the presence, location, size, and type of each hemorrhage and infarct. We recorded the size of ...
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Purification of epidermal plasminogen activator inhibitor
... In addition, crz-plasmin inhibitor [ 171, the major anti- fibrinolytic inhibitor in plasma, showed slow in- hibition to urokinase, however it possessed strong inhib[r] ...
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Retinoic Acid Upregulates the Plasminogen Activator System in Human Epidermal Keratinocytes
... minogen activator inhibitor-1, but a prolonged induction of urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor mRNA ...the plasminogen activ- ...
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Tissue type plasminogen activator increases the binding of glu plasminogen to clots
... tissue-type plasminogen activator (t-PA) increases the binding of 125I-glu- plasminogen to clots made from human plasma or purified fibrinogen in a time and t-PA concentration dependent ...of ...
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