Poloxamer 188
ENHANCEMENT OF DISSOLUTION RATE OF OLMESARTAN BY SOLID DISPERSION IN CROSSPOVIDONE AND POLOXAMER 188 ALONE AND IN COMBINATION
... increased. Poloxamer 188 gave higher enhancement in the dissolution rate of olmesartan than Crosspovidone when used at the same ...and Poloxamer 188 (factor B) in enhancing the dissolution ...
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ENHANCEMENT OF DISSOLUTION RATE OF ACECLOFENAC BY SOLID DISPERSION IN STARCH 1500 AND POLOXAMER 188
... surfactant, Poloxamer 188 have been used individually as carriers in solvent deposition and solid dispersion systems respectively, no reports are available on their combined use in enhancing the dissolution ...
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Gene transfer to rat cerebral cortex mediated by polysorbate 80 and poloxamer 188 nonionic surfactant vesicles
... amer 188 (P) and polysorbate 80 (P80) into nanovesicles – based on 2,3-di(tetradecyloxy)propan- 1-amine cationic lipid (D) – destined for gene delivery to central nervous system ...with poloxamer 188 ...
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FORMULATION OF TELMISARTAN TABLETS EMPLOYING SOLID DISPERSIONS IN MCC PH 102 AND POLOXAMER 188 AS PER 22 FACTORIAL DESIGN
... the above polynomial equation, the optimized telmisartan tablet formulation with NLT 85% dissolution in 10 min could be formulated employing MCC at 1: 4.36 ratio of drug: MCC PH102, and Poloxamer 188 at 3% ...
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FORMULATION AND EVALUATION OF DOLUTEGRAVIR SODIUM SOLID DISPERSIONS AND FAST DISSOLVING TABLETS USING POLOXAMER 188 AND JACK FRUIT SEED STARCH AS EXCIPIENTS
... drug, poloxamer-188, solid dispersion DF3, CCS, DFT6, and DFT9 formulations representing the rates of heat ...for poloxamer-188 was observed at ...
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Improvement in Dissolution Rate of Cefuroxime Axetil by using Poloxamer 188 and Neusilin US2
... using poloxamer 188 alone and combination of poloxamer 188 and Neusilin US2 by fusion and surface adsorption ...for poloxamer 188 at various concentrations (0, ...
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FORMULATION AND EVALUATION OF TELMISARTAN SOLID DISPERSIONS USING ENTADA SCANDENS SEED STARCH AND POLOXAMER 188 AS SUPERDISINTEGRANTS
... The FTIR spectral investigations were carried out on pure drug of telmisartan, poloxamer-188, ESS4, and solid dispersions of telmisartan TP7 and TPS7. Telmisartan pure drug showed a broad peak at 3143.31/cm ...
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Evaluation of Dissolution Enhancement of Aprepitant Drug in Ternary Pharmaceutical Solid Dispersions with Soluplus and Poloxamer 188 Prepared by Melt Mixing
... APT/Poloxarer 188 (Figure 7a), several dispersions in the scale of 370, 430 and 750 nm for 10%, 20% and 30% ...APT/Poloxamer 188/SOL SDs, where nano-dispersion with size varying from 340, 410 and 720 ...
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Development of Fast Dissolving Tablets of Nisoldipine by Solid Dispersion Technology using Poloxamer 407 and Poloxamer 188
... with poloxamer 188 and poloxamer 407 with aim of enhanced dis- solution ...nisoldipine poloxamer SD in the ratio of 1:5 prepared by solvent evaporation meth- ...
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ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF ERLOTINIB HYDROCHLORIDE BY SOLID DISPERSION TECHNIQUE WITH POLOXAMER 188: PREPARATION AND IN VITRO EVALUATION
... ABSTRACT: Solid dispersions (SDs) of Erlotinib hydrochloride (ETN) were prepared to enhance the solubility by solvent evaporation (SE) and Melting (MM) method using poloxamer 188 (PL 188) in the ...
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DEVELOPMENT OF FAST DISSOLVING TABLETS OF AMLODIPINE BESYLATE BY SOLID DISPERSION TECHNOLOGY USING POLOXAMER 407 AND POLOXAMER 188
... flow. Poloxamer 407 (P407) and poloxamer 188 (P188) were used as the carriers for the preparation of SDs with amlodipine besylate ...[8]. Poloxamer is a synthetic block copolymer of ethylene ...
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“EFFECT OF POLOXAMER 188 ON IN VITRO DISSOLUTION PROPERTIES OF ANTIPSYCHOTIC SOLID DISPERSIONS” by N.L Prasanthi*, S.S.manikiran, S. Sowmya, B.Anusha, N. Rama rao, india.
... of poloxamer 188 on the equilibration solubility of ziprasidone in water at room temperature was carried out by adding an excess of drug (50 mg) in to a screw-capped glass vial containing 10 ml of water and ...
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PERFORMANCE OF POLOXAMER 188 AND POLOXAMER 407 AS HYDROPHILIC CARRIER ON THE BINARY MIXTURES OF MESALAZINE
... both Poloxamer 407 was able to produce 98 % of the drug in solution within 6min in case of Hydrochloric Acid Buffer pH ...with Poloxamer 188 which release 96% 11min in same dissolution ...
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Solid Dispersion of Nateglinide in Polyoxy Ethylene-Polyoxy Propylene Block Copolymer: in vitro and in vivo Evaluation
... and poloxamer 188 showed that the melting peak of nateglinide was shifted to a lower temperature ...of poloxamer 188 was almost unchanged but the melting endotherms of nateglinide showed ...
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Enhancement of Solubility and Dissolution Properties of Lacidipine by Solid Dispersion
... particle size reduction, and solid dispersion formation are the approaches most often used to reach this goal. 1,2 The incorporation of drug into hydrophilic carriers has frequently been reported to increase the ...
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Physicochemical features and transfection properties of chitosan/poloxamer <br />188/poly(D,L-lactide-co-glycolide) nanoplexes
... of poloxamer 188 instead of classical stabilizers/surfactants favored the appearance of ideal physicochemical parameters for the colloids, with high plasmid entrapment efficiency and low ...
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Journal of Applied Pharmaceutical Science
... and poloxamer 188) were within the theoretical range for processing into tablet dosage form (Table ...or poloxamer 188) in each solid dispersion formulations was found to be the optimum ...
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Title: ANTIEPILEPTIC DRUGS: TREATMENT IN ELDERLY PATIENTS. Author: Callegari C. *, Bianchi L., Vender S Keyword: Antiepileptic drugs, elderly patients, gabapentinPage No: 96-102Abstract: Introduction: This study aims to examine qualitatively the use of AEDs in a population of elderly patients in nursing homes, including the prescription of specialist and monitoring. Methods: This p revalence study was carried out in a state-founded nursing home providing assistance and rehabilitation for elderly people. The first objective of the study is to determine the prevalence of the use of antiepileptic drugs. The second objective is to study the monitoring the dosage modification from the time of admission of the patient until the end of the study. Results: In the period of time that we took into consideration 65 of 402 patient’s monitored patients had at least one anti-epileptic therapy (prevalence of 32%). The antiepileptic drug most prescribed was gabapentin with a frequency of 63.6%. Discussion: The prevalence use of AEDs has beeen 32%. The second objective concerns the drugs monitoring and it has also been achieved and shows how gabapentin is the most prescribed drug (53.8% psychiatrist) and was introduced mainly for anxiety disorders, psychosis, neuropathic pain and mood disorders. Keywords: Antiepileptic drugs, elderly patients, gabapentin Download PDF
... using Poloxamer 188 as a ...Piroxicam-Poloxamer 188 solid ...using Poloxamer 188 as a ...that poloxamer 188 can successfully resolve the problem of slow dissolution ...
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Practical preparation procedures for docetaxel-loaded nanoparticles using polylactic acid-co-glycolic acid
... zeta potential was 18.94 mV, − 20.39 mV, and − 16.44 mV, respectively. With ethyl acetate, the size of the nanoparticles was 438.8 nm, 1044.2 nm, and 393.6 nm with Poloxamer 188, TPGS, and polyvinyl ...
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Design and pharmacokinetics of a new formulation of modified release of clindamycin orally for dogs
... (7). Poloxamer 188 will be used too, it is used in a variety of pharmaceutical formulations that can be administered orally, it is not considered toxic or irritating, this polymer allows developing both, ...
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