poly(ADP-ribosyl)ation
3-aminobenzamide blocks MAMP-induced callose deposition independently of its poly(ADPribosyl)ation inhibiting activity
... of poly(ADP-ribosyl)ation has been widely and conclusively documented in animal and plant studies (present study and Chen et ...of poly(ADP-ribosyl)ation, several ...
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Poly(ADP-Ribosyl)ation of High Mobility Group Box 1 (HMGB1) Protein Enhances Inhibition of Efferocytosis
... that poly(ADP-ribosyl)ation contributes to the release of HMGB1 into the extracellular milieu, but also that PARylation may con- tribute to the translocation of HMGB1 from the nucleus to ...
11
Regulation of Wnt/ß-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding
... sumoylation, poly(ADP-ribosyl)ation (PARylation) and ...The poly(ADP- ribose)polymerase (PARP) tankyrase PARylates AXIN1/2, an essential central scaffolding protein in the ...
44
Flow-cytometric assessment of cellular poly(ADP-ribosyl)ation capacity in peripheral blood lymphocytes
... is poly(ADP-ribose) polymerase-1 (PARP-1, EC ...of poly(ADP-ribose) ...of poly(ADP-ribose) metabolism in the ageing process has long been suggested, as we could show that the ...
9
Activation of the Poly(ADP-Ribose) Polymerase Pathway in Human Heart Failure
... increased poly(ADP-ribosyl)ation in human failing hearts ...increased poly(ADP-ribosyl)ation in our samples was most probably due to activation of the catalytic ...
10
Structural and Functional Basis for ADP-Ribose and Poly(ADP-Ribose) Binding by Viral Macro Domains
... by poly(ADP-ribosyl)ation in re- sponse to the ...cytoplasmic poly(ADP- ribosyl)ated ...this poly(ADP- ribosyl)ated messenger would be exported from ...
10
Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase
... ribose.  -Actin was used as a loading control. (B) Analysis of PARP-1 protein levels over the course of infection with HSV-1. Serum-starved fibroblasts were infected with HSV-1 (3 IU/cell) or mock infected. At 1 hpi, ...
10
Becker, Annette (2010): Regulation of MeCP2 induced heterochromatin remodeling. Dissertation, LMU München: Fakultät für Biologie
... the poly(ADP-ribosyl)ation level within two disordered regions of MeCP2 (ID and TRD) rescues the phenotype of a MBD RTT mutant severely impaired in heterochromatin ...their ...
107
Mechanisms of lymphocytotoxicity induced by extracorporeal photochemotherapy for cutaneous T cell lymphoma
... photochemotherapy for cutaneous T cell lymphoma is apparently mediated by DNA damage, subsequent poly (ADP-ribosyl)ation and adenine nucleotide depletion. It is not known how the DNA damage ...
7
Myocardial Ischemic Preconditioning in Rodents Is Dependent on Poly (ADP-Ribose) Synthetase
... could, in turn, protect against the deleterious effects of the ischemia and reperfusion, via inhibition of the subsequent, massive activation of PARS, which oc- curs in naïve (nonpreconditioned wild-type) ani- mals ...
12
Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers
... Three putative PBM, supposed to be present in hTop1, have been identified, two of them are positioned in the core DNA-binding domain (amino acids 261–280 and 532–551, respectively), whereas the third one is in the linker ...
8
Original Article Polymorphisms in poly (ADP-ribose) polymerase-1 (PARP1) promoter and 3’ untranslated region and their association with PARP1 expression in breast cancer patients
... a biological phenotype similar to BRCA- defective breast cancer [19]. It has unique molecular characteristics of lacking ER, PR, and HER2 expression, often with early metas- tases and a relative lack of targeted ...
13
The Protective Role of Endogenous Estrogens in Carrageenan-Induced Lung Injury in the Rat
... Indirect immunofluorescence staining was per- formed on 7- m thick sections of unfixed rat lung. Sections were cut in with a Slee and London cryostat at –30 ⬚ C, transferred onto clean glass slides, and dried overnight ...
10
Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach
... many poly(ADP-ribose) polymerase (PARP) inhibitors have been enrolled in clinical trials as a combination therapy for several types of cancer, and many of these were licensed by the Food and Drug ...
13
Update on Poly ADP ribose polymerase inhibition for ovarian cancer treatment
... PARP: Poly(ADP-ribose) polymerase; PARPi: PARP inhibitors; HR: homologous recombination; HRD: homologous recombination deficiency; BRCA: breast related cancer antigens; gBRCAm: germline breast related ...
18
Olaparib in the management of ovarian cancer
... a poly(ADP-ribose) polymerase (PARP) inhibitor, capitalizes on this concept and is the first drug in its class approved for patients with ovarian ...
9
<p>Role of pseudohypoxia in the pathogenesis of type 2 diabetes</p>
... Abstract: Type 2 diabetes is caused by persistent high blood glucose, which is known as diabetic hyperglycemia. This hyperglycemic situation, when not controlled, can overproduce NADH and lower nicotinamide adenine ...
8
<div>Emerging treatment options for ovarian cancer: focus on rucaparib</div>
... Abstract: Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) are an exciting class of anticancer drugs, which have revolutionized the management of BRCA mutant/homologous recombination-deficient ...
12
Defective DNA repair mechanisms in prostate cancer: impact of olaparib
... aggressiveness. Poly adenosine diphosphate ribose polymerase (PARP) proteins play a key role in DNA repair mechanisms and represent a valid target for new ...
6
Emerging treatment options for recurrent ovarian cancer: the potential role of olaparib
... As more work is carried out on these cellular pathways, a greater understanding of secondary resistance, and indeed potential biomarkers of initial response to PARP inhibition, will be delineated. There is already ...
10