potassium ATP-dependent channels
The pharmacology of calcium and ATP-dependent potassium channels in erythrocytes and in smooth skeletal muscle
... Potassium channels are a diverse class of membrane proteins found in virtually all cells. The first part of this study concerns the pharmacology of the calcium activated potassium channel found in ...
215
Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia
... Lung wet/dry weight ratios were comparable between groups, suggesting the absence of pulmonary edema. This is in contrast to in vivo observations of endotoxe- mic mice, where lung edema was found to be iNOS- ...
10
The Mechanism of Preventive Effect of Captopril on Renal Ischemia Reperfusion Injury is Independent of ATP Dependent Potassium Channels
... In this study, we found out that IR caused severe renal injury and captopril was able to prevent this damage. Ang II is a potent vasoconstrictor, known to activate channels that depolarize vascular smooth muscle ...
5
Regulation of vascular ATP-sensitive potassium channels by calcium and inflammatory mediators
... Ca^"^- dependent and -Independent Isoforms exist, although how specificity of action Is achieved Is not completely ...Ca^* channels, K^ channels and phosphollpases (Andrea and Walsh, ...
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The involvement of ATP-sensitive potassium channels in novel forms of myocardial protection
... clathrin coats and promote lysosomal degradation of cytosolic proteins. In addition to the cytosolic forms of HSP70 (constitutive HSP73 and inducible HSP72) a mitochondrial matrix-localised isoform (mt-HSP70) exists ...
164
ATP sensitive potassium channels mediate contraction induced attenuation of sympathetic vasoconstriction in rat skeletal muscle
... However, a single therapeutic dose of oral glibenclamide has been shown to decrease baseline calf blood flow in normal hu- man subjects (51). Based on our experimental findings in rats, we speculate that in the clinical ...
9
Lactate activates ATP sensitive potassium channels in guinea pig ventricular myocytes
... of ATP at which activation of the channels occurs and the much higher levels of ATP maintained during myocardial ...on ATP-sensitive potassium channels in adult guinea pig ...
7
Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231
... the potassium-dependent changes in membrane potential play a crucial role in the proliferation of many types of normal and tumor ...of potassium channels in the cell mem- brane produces a ...
13
In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root
... Although oroxylin A will most likely never be used clini- cally to achieve tocolysis, the data presented here clearly demonstrate that oroxylin A is able to relax pregnant rat myometrium through a mechanism involving ...
7
Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats
... Effects of hyperglycemia on SUR-2A and Kir6.2 expres- sion levels were further characterized by exposing cul- tured neonatal rat cardiac myocytes to various concentrations of glucose in vitro. The SUR-2A and Kir6.2 ...
9
Functional cell biology and molecular pharmacology of ATP sensitive potassium channels
... octomeric combinations of two distinct types of protein subunit. The pore is formed of four Kir6.1 or Kir6.2 subunits, each of which is associated with a regulatory sulphonylurea receptor (SUR) subunit. Kir6.1 and Kir6.2 ...
125
Modulation of pulmonary vasomotor tone in the fetus and neonate
... ), ATP- dependent (K ATP ), and several voltage-dependent (K V ) potassium channels have been identified on both pulmonary endothelial and vascular smooth muscle ...endothelial ...
6
ATP-dependent potassium channels are implicated in simvastatin pretreatment-induced inhibition of apoptotic cell death after renal ischemia/reperfusion injury
... Another potential mechanism of in- creased apoptotic cell death after I/R in- jury is upregulation of Bax which has been demonstrated by Jin et al. to be mediated by p53 transcription factor ac- tivation. According to ...
10
Ion Channels in Peripheral Blood Mononuclear Cells – Effect of Culture and Ascorbic Acid.
... Potassium channels in lymphocytes are responsible for the repolarization of membrane during lymphocyte ...Since potassium channels play an important role in lymphocyte function, drugs that ...
126
Pyruvate-Phosphate Dikinase of Oxymonads and Parabasalia and the Evolution of Pyrophosphate-Dependent Glycolysis in Anaerobic Eukaryotes
... stream of the catalytic His458, where a threonine is conserved in all but the parabasalia (Fig. 1 and Fig. S1 in the supplemen- tal material). In C4 plants, this threonine is directly involved in a particular form of ...
7
ATP dependent DNA ligases
... By catalyzing the joining of breaks in the phosphodiester backbone of duplex DNA, DNA ligases play a vital role in the diverse processes of DNA replication, recombination and repair. Three related classes of ...
7
Conversion of amylase secreting rat pancreatic AR42J cells to neuronlike cells by activin A
... cytoplasmic free calcium concentration in response to depolarizing concentration of potassium. Moreover, activin-treated AR42J cells expressed mRNA for alpha 1 subunit of the neuroendocrine/beta cell-type ...
12
Effects of Thrombin on the Potassium and ATP Content of Platelets
... In six experiments, twice washed platelets from 3-ml portions of plateletrich plasma were incubated at 370 C in Trisbuffered saline containing radioactive potassium K42 in addition to st[r] ...
8
Stimulation of hERG1 channel activity promotes a calcium- dependent degradation of cyclin E2, but not cyclin E1, in breast cancer cells
... his event could provide the driving force for calcium entry. We then utilized Fura-2 fluorescence to detect NS1643- induced changes in intracellular calcium, and discovered that 1643 treatment induced a dramatic increase ...
9
Regularities and Causality; Generalizations and Causal Explanations
... containing sodium ions to which hydrogen was gradually added. The results contradicted absolute permeability values for hydrogen obtained by applying the current equation to data from a membrane bathed in a sodium free ...
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