Pr/sub 17/Fe/sub 77.5/B/sub 4/Ga/sub 1.5/
In vitro and in vivo targeting imaging of pancreatic cancer using a Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub> nanoprobe modified with anti-mesothelin antibody
... The T2 signal values of experimental group xenograft were decreased by 342.533 ± 42.6 after injection of the target probe, and the control group was decreased by − 61.233 ± 33.9 after injection of saline solution, while ...
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Effect of interaction of magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> and artesunate on apoptosis of K562 cells
... O 4 , or the copolymer of ART with MNPs- Fe 3 O 4 in the presence or absence of 40 µ M Z-VAD-FMK for 48 ...L, 5 mg/mL) was added to each well and incubated for 4 ...
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Immobilized transferrin Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub> nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery
... Figure 1. By coupling GA with amino- immobilized Fe 3 O 4 @SiO 2 , the surface of the magnetic nanoparticle can be modified with both carboxyl and protected amino ...
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Biosafety evaluation of Janus Fe<sub>3</sub>O<sub>4</sub>-TiO<sub>2</sub> nanoparticles in Sprague Dawley rats after intravenous injection
... molecular weights. Immunoblots for expression of p38, p-p38, JNK, p-JNK, HO-1, ERK, c-Jun, cleaved caspase 3, Bcl2, Bax, P50, p53, Nrf2, Akt, and GAPDH were detected. All antibodies for Western blot in this study ...
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Magnetic nanoparticle of Fe<sub>3</sub>O<sub>4</sub> and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
... After treatment with drugs, total RNA was isolated using Trizol reagent (Invitrogen Life Technologies, Carlsbad, CA, USA) according to the manufacturer’s protocol. One microgram of total RNA was used to generate cDNA ...
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The effect of magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> on immune function in normal ICR mice
... Nanotechnology offers an efficient alternative for cancer diagnostics and tumor target treatment due to the unique properties of nanostructures, such as large surface-to-volume ratio, porous structure, embedded effect, ...
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Synthesis of composite magnetic nanoparticles Fe<sub>3</sub>O<sub>4</sub> with alendronate for osteoporosis treatment
... Reagents used in cell culture include albumin solution from bovine serum (Sigma-Aldrich Co.), ascorbic acid (C 6 H 8 O 6 ; Sigma-Aldrich Co.), Dulbecco’s Modified Eagle’s Medium (DMEM; high glucose with l -glutamine and ...
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Biocompatibility of magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles and their cytotoxic effect on MCF-7 cells
... Elemental analysis was performed using scanning electron microscopy-energy dispersive x-ray spectroscopy (SEM-EDS, EDAX 9100; EDAX International, Prairie View, IL). X-ray diffraction data were collected using an XD-D1 ...
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Preparation of Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles coated with gallic acid for drug delivery
... different pH levels which are similar to the pH of the stomach and the pH of the blood. Generally, the pH of the stomach varies from 1–2 to 4–5. After eating, the stomach releases proteases and ...
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Fe<sub>3</sub>O<sub>4</sub>-based PLGA nanoparticles as MR contrast agents for the detection of thrombosis
... developed Fe 3 O 4 -based poly(lactic-co- glycolic acid) (PLGA) nanoparticles (NPs) surface-modified with a cyclic Arg-Gly-Asp (cRGD) peptide as an MR contrast agent for the detection of ...The Fe 3 ...
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Magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> enhance docetaxel-induced prostate cancer cell death
... O 4 (10 µ g/mL or 100 µ g/mL) in the absence or presence of DTX (1 ...of 1 mg/mL of propidium iodide (PI; Sigma- Aldrich), the cells were passed through a 40 mm nylon mesh for analysis using an LSRII ...
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Pharmacokinetic parameters and tissue distribution of magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles in mice
... of Fe 3 O 4 MNPs between the experimental and control groups, indicating that Fe 3 O 4 MNPs can pen- etrate the blood–brain ...of Fe 3 O 4 MNPs as drug carriers may overcome the ...
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Preparation and in vitro evaluation of doxorubicin-loaded Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles modified with biocompatible copolymers
... that Fe 3 O 4 -PLGA-PEG 2000 -doxorubicin has dose-dependent and time-dependent cytotoxicity against the A549 lung can- cer cell line (IC 50 ...that Fe 3 O 4 -PLGA-PEG 3000 -doxorubicin has ...
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The effects of magnetite (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles on electroporation-induced inward currents in pituitary tumor (GH<sub>3</sub>) cells and in RAW 264.7 macrophages
... M Fe(II) and 1 M Fe(III) were prepared by dissolving FeCl 2 and FeCl 3 , ...produce Fe 3 O 4 NPs, 1 mL Fe(II) and 4 mL Fe(III) aqueous solutions were mixed ...
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Polyetherimide-grafted Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub> nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging
... 60%. Fe 3 O 4 @SiO 2 /PEI, Fe 3 O 4 @SiO 2 / PEI/Sc shRNA, or Fe 3 O 4 @SiO 2 /PEI/VEGF shRNA was incubated with the cells in serum-free medium for 6 hours, and then replaced ...
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Synergistic effect of magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> with gambogic acid on apoptosis of K562 leukemia cells
... κ B, survivin, and β -actin were purchased from Santa Cruz Biotechnology (Santa Cruz, ...O 4 (State Key Lab of Bioelectronics, Nanjing, China) were well distributed in RPMI 1640 medium containing 10% (v/v) ...
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Fe<sub>3</sub>O<sub>4</sub>/Au magnetic nanoparticle amplification strategies for ultrasensitive electrochemical immunoassay of alfa-fetoprotein
... for 5 minutes and dried in ...in 5 mL 0.08 M HAuCl 4 solution containing ...Ab 1 for one ...Ab 1 /Au/GCE was incubated in 3% bovine serum albumin and phosphate-buffered solution at 37 ° ...
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Biological responses to core–shell-structured Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>-NH<sub>2</sub> nanoparticles in rats by a nuclear magnetic resonance-based metabonomic strategy
... for Fe@Si NP intravenous adminis- tration: control group, low-dose 10 nm Fe@Si NP-exposure group (10L), low-dose 20 nm Fe@Si NP-exposure group (20L), high-dose 20 nm Fe@Si NP-exposure group ...
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The changes of T lymphocytes and cytokines in ICR mice fed with Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles
... with Fe 3 O 4 magnetic nanoparticles (Fe 3 O 4 ...The Fe 3 O 4 -MNPs were synthesized, and their characteristics such as particle size, zeta potential, and X-ray diffraction ...
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Multifunctional magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles combined with chemotherapy and hyperthermia to overcome multidrug resistance
... and 5-Br-Tet from Fe 3 O 4 ...with Fe 3 O 4 ...with 5-BrTet only decreased the speed of tumor growth and had much less effect on overcoming multidrug resistance than did ...
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