Pre B-cell acute lymphoblastic leukemia
Childhood pre B cell acute lymphoblastic leukemia with translocation t(1;19)(q21 1;p13 3) and two additional chromosomal aberrations involving chromosomes 1, 6, and 13: a case report
... in B cell acute lympho- blastic leukemia (B-ALL), and can be found in both adult and pediatric patients at an overall frequency of 3 to 5% [1, ...of pre-B-ALL carrying the ...
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T cell receptor alpha , beta , and gamma genes in T cell and pre B cell acute lymphoblastic leukemia
... gamma-T cell receptor (TCR) gene activation within acute lymphoblastic leukemias (ALLs) that represent early stages of B and T cell ...
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The Role of PU.1 and Spi-B in B Cell Acute Lymphoblastic Leukemia
... in B cell differentiation [40, ...of pre-B cells to immature B cells. Btk – deficient pre-B cells had increased proliferation capacity in response to IL7 ...these ...
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Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China
... powerful pre- dictors of treatment outcome in childhood ALL [7 – ...than B-ALL patients [8, 10, ...established leukemia groups [19 – ...on B-ALL, whereas MRD studies in T-ALL were ...of ...
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Cytotoxic and apoptogenic activity of Bryonia aspera extract on pre-B acute lymphoblastic leukemia cell lines
... Total RNA was isolated 48 h after treatment with B. aspera extract using RNX plus (SinaClon, Iran). The reverse transcription (RT) reaction was performed using the revertAid First Strand cDNA Synthesis Kit (Takara ...
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B cell origin of non T cell acute lymphoblastic leukemia A model for discrete stages of neoplastic and normal pre B cell differentiation
... non-T cell ALLs tested, and given its absence on T cell and myeloid tumors, it appears to be an exceptional marker to define cells of B ...leukemic pre-B cell phenotypes were ...
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Case Report B-acute lymphoblastic leukemia occurring in two pediatric patients with a history of prior Wilms tumors
... Therapy-related acute leukemia (t-AL) is an observed carcinogenesis due to the toxic side effects of ion- izing radiation and/or conventional chemotherapy for primary ...therapy-related acute myeloid ...
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Expression of the polycomb group gene Bmi1 does not affect the prognosis of pediatric acute lymphoblastic leukemia
... precursor B leukemic cells is related to the clinical course, cell profile, and ...In acute lymphoblastic leukemia, it was reported that CD90+/CD110+ cells in acute ...
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T cell receptor gamma and delta rearrangements in hematologic malignancies Relationship to lymphoid differentiation
... T cell receptor delta was frequently rearranged while T cell receptor gamma was in the germline ...T cell receptor delta and gamma rearrangements were ...
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Original Article CD317 is over-expressed in B-cell chronic lymphocytic leukemia, but not B-cell acute lymphoblastic leukemia
... common B-cell markers, like Rituximab (anti-CD20) and Ca- mpath (anti-CD52) ...in B- ALL. A. Bone marrow specimens from 8 B-ALL patients and 8 healthy individuals were stained with ...
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... 24. Borkhardt A, Cazzaniga G, Viehmann S, Valsecchi MG, Ludwig WD, Burci L, et al. Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in ...
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PHARMACEUTICAL SCIENCE BRINGS GENETICS AND IMMUNOLOGY TOGETHER TO EVOLVE A NEW DIMENSION IN TREATING CHILDHOOD CANCER: A REVIEW
... ABSTRACT: Surgery, chemotherapy and radiation therapy has been the cornerstone of cancer management for decades. Since a decade or so, targeted therapies by way of Imatinib and Trastuzumab arrived that specifically ...
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<p>IFN-γ and TNF-α aggravate endothelial damage caused by CD123-targeted CAR T cell</p>
... these cell lines and primary AML blasts is presented in Figure ...AML cell lines KG-1a and MOLM- 13 are CD123-positive; only NALM-6 cells are CD19- ...
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Intracranial hemorrhage in adult patients with hematological malignancies
... Patients with CNS lymphoma or myeloma involvement should be aware of the increased risk of ICH [23-27]. L-Asparaginase is one of the combined chemotherapy agents frequently used to treat acute lymphoblastic ...
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Analysis of the expression of PHTF1 and related genes in acute lymphoblastic leukemia
... in leukemia have not been reported. FEM1b (feminization-1 homolog b) has been identified as a binding partner for PHTF1 ...T-ALL cell lines, we performed experiments involving the down regulation or ...
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Histiocytic sarcoma combined with acute monocytic leukemia: a case report
... pleomorphic neoplastic cells, most of which were large, and round to oval in shape. Some neoplastic giant cells were observed. The cytoplasm was usually abundant, and the nuclei were generally large and round with a ...
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Recent advances in the biology and treatment of B-cell acute lymphoblastic leukemia
... The improved outcomes with TKIs set the stage for the consideration of chemotherapy de-escalation for the treat- ment of Ph + ALL to lessen the morbidity and mortality associated with induction chemotherapy. In ...
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SYK as a New Therapeutic Target in B Cell Precursor Acute Lymphoblastic Leukemia
... in B/T- lineage Acute Lymphoblastic Leukemia Patients with SYK and STAT3 expression using the RMA Normalized Data- base obtained from 3 ...diagnosed B-lineage ALL (GSE1187 (N = 207), ...
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Altered neutrophil immunophenotypes in childhood B‑cell precursor acute lymphoblastic leukemia
... PB cell counts, tumor cytogenetics and other clinical features of the disease, except for a lower frequency of altered CD10 and CD33 expression in patients with MLL gene ...
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Different stages of B cell differentiation in non T acute lymphoblastic leukemia
... of acute lymphoblastic leukemia (ALL) and correlated with the immunological phenotypic expression on primary or phorbol diester (12-O-tetradecanoylphorbol-13-acetate [TPA])-induced ...
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