pre-miRNA
MicroRNA Detection Using a Double Molecular Beacon Approach: Distinguishing Between miRNA and Pre-miRNA
... mature miRNA, the molecular beacon hybridizes to matching nucleotides in the mature ...the pre-miRNA occurs when the pre-miRNA molecular beacon hybridizes to the loop sequence of the ...
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Strain-Specific Differences in the Impact of Human TRIM5α, Different TRIM5α Alleles, and the Inhibition of Capsid-Cyclophilin A Interactions on the Infectivity of HIV-1
... a pre-miRNA targeting TRIM5 ␣ , and/or overexpression of TRIM5 ␥ ), the inhibition of cyclophilin A (CypA)-CA interactions, and the expression of different allelic variants of human TRIM5 ␣ on the ...
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Genetic variants of miRNA sequences and non–small cell lung cancer survival
... of pre-miRNAs and their surrounding ...in pre-miRNAs and their surrounding regions for all the ethnic groups (Asian, European, and African) of 400 known human ...the pre-miRNA regions ...
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MicroRNAs AS BIOMARKERS FOR ACUTE MYOCARDIAL INFARCTION - SMALL MOLECULES WITH A HUGE POTENTIAL
... primary miRNA transcripts (pri-miRNA) by RNA polymerase II and RNA polyme- rase ...— pre-miR- NA. Then, pre-miRNA is exported from the nucleus to the cytoplasm by exportin-5 to be ...
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Identification of MicroRNA Like Molecules Derived from the Antigenome RNA of Hepatitis C Virus: A Bioinformatics Approach
... 10 pre-miRNAs structures with high VMir scores [23] and clas- sified as real pre-miRNA using MiPred [24] were identified in the antigenome of HCV reference strain H77 (see Table ...
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Fast selection of miRNA candidates based on large scale pre computed MFE sets of randomized sequences
... of pre-miRNAs, the mature miRNA sequence and its presumed target(s) [19-21], many of which are available online ...of miRNA sequences or combinations thereof ...of miRNA sequences between ...
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Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression
... these miRNA expression profiles in the cells were analysed using UCSC (https://xenabrow- ...selected miRNA-144 and miRNA-126 for further ...profile, miRNA-144 and miRNA-126 showed much ...
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MicroRNA and mRNA analysis of two species of New Zealand Pachycladon : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, Manawatu, New Zealand
... 21 miRNA families were chosen for pre-miRNA ...cheesemanii miRNA hairpins and 13 P. fastigiatum miRNA hairpins were validated ...
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Identification of microRNAs in ecological model plant Mimulus
... of pre-miRNA is detached to create a short double-stranded RNA (dsRNA), a single strand of the dsRNA acts as mature miRNA ...mature miRNA production [9], that also mostly integrate the mature ...
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Deciphering microRNAs and Their Associated Hairpin Precursors in a Non-Model Plant, Abelmoschus esculentus
... novel miRNA predictions may depend on the chromosomal number as ...Precursor miRNA sequencing has been done in mouse with locked nucleic acids to abstract other non-coding RNAs ...utilizing ...
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MicroRNAs associated with therapy of non-small cell lung cancer
... microRNA; pre-miRNA: precursor micro- RNA; RISC: RNA induced silencing complex; EGFR-TK: epidermal growth factor receptor-tyrosine kinase; PI3K: phosphoinositide-3 kinase; Akt: protein kinase-B; mTOR: ...
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Sequence Motif Based One Class Classifiers Can Achieve Comparable Accuracy to Two Class Learners for Plant microRNA Detection
... For example, NOVOMIR [16], using a series of filters and a statistical model reportedly detects pre-miRNA with a sensitivity of 80% at a specificity of 99%. MiRenSVM combines three SVMs for prediction ...
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Adenovirus VA1 Noncoding RNA Can Inhibit Small Interfering RNA and MicroRNA Biogenesis
... distinct miRNA genes have been identified in the genomes of humans and other eukaryotic species ...a pre-miRNA, by a nuclear RNA processing enzyme termed Drosha (19, 20, ...resultant ...
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Epstein-Barr Virus BART MicroRNAs Are Produced from a Large Intron prior to Splicing
... BART4 miRNA. However, the BART1-3p miRNA was expressed in BC1 at levels compa- rable to C15 and ...BART6 miRNA had several deletions within the proposed hairpin loop, with a deletion of a U in C15, ...
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Intratumoral heterogeneity of microRNA expression in rectal cancer
... same miRNA may affect several genes, but also that the same gene may be downregulated by different ...of miRNA activity plays a central role in carcinogenesis ...
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Plasma Level of miRNA-7, miRNA-409 and miRNA-93 as Potential Biomarkers for Colorectal Cancer
... of miRNA-93 (hsa-miR-93-5p), miRNA-7 (hsa-miR-7-5p) and miRNA-409 (hsa- miR-409-5p) were evaluated in plasma of CRC patients compared with healthy controls, to identify their potential application as ...
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Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis
... circulating miRNA is associated with exosomes. Exosome associated miRNA is reported to be more stable and resistant to RNase enzymatic activ- ity compared to non-exosome associated miRNAs [17, ...of ...
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Original Article Array profiling identified dysregulated miRNAs and target genes and pathways in laryngeal squamous cell carcinoma
... Expression analysis using the miRNA array was initially per- formed on five laryngeal squa- mous cell carcinoma tissues and their corresponding adja- cent non-neoplastic tissues. We found there were 50 miR- NAs ...
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Novel miRNA Sponges toS pecifically ModulateG ene Expression inC olon CancerC ells
... for miRNA-365 and another for miRNA-145, each one of them formed by 7 specific multiple tandem binding sites ...and miRNA inhibition effectiveness, but we show that 7 MBS were sufficient to strongly ...
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MicroRNA-mediated regulation of target genes in several brain regions is correlated to both microRNA-targeting-specific promoter methylation and differential microRNA expression
... between miRNA-mediated gene regulation and miRNA-targeted-specific promoter ...of miRNA target genes (a) and miRNA-targeted-specific promoter methylation ...the miRNA-centric-view, thus ...
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