Pre-osteoclasts
Original Article Upregulation of notch signaling in hBMSCs promotes the proliferation and differentiation of pre-osteoclasts
... Abstract: During bone remodeling, osteoblasts and osteoclasts have a mutual and coefficient influence on each other. However, the specific mechanisms by which they interact are unclear and need further ...
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Exposure to receptor activator of NFκB ligand renders pre osteoclasts resistant to IFN γ by inducing terminal differentiation
... It is noteworthy to point out that the dominant/irreversible inhibitory effects of IFN- γ on osteoclastogenesis are fun- damentally different to the transient/reversible inhibitory effects of IL-4 on this process, which ...
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FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans
... Murine bone marrow cells were cultured for 18 h in tis- sue culture dishes in complete MEM-α media to remove adherent cells. Non-adherent cells were transferred to new tissue culture dishes and cultured for 2 days in ...
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Osteoclasts and Microgravity
... Using NASA’s rotary cell culture system and mouse bone marrow cultures, Sambandam and associates found that simulated microgravity modulated osteoclastogenesis via control of autophagy [59]. Ethiraj et. al. reported ...
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Pharmacological Inhibition of NFκB Reduces Prostate Cancer Related Osteoclastogenesis In Vitro and Osteolysis Ex Vivo.
... Prostate cancer cells interact with osteoblasts and clinical evidence suggests that prostate cancer osteoblastic lesions give rise to increased osteoclastic activity and thus osteolytic lesions and bone loss [25, 26]. ...
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Journal Pre-proofs. Osteoclasts may contribute bone substitute materials remodeling and bone formation in bone augmentation
... or pre-osteoclasts, or low-level-laser-treatment (LLLT) application on the bone augmentation site to enrich and active osteoclasts during remodeling could accelerate remodeling and promote ...
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Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts
... Osteoclasts are derived from the monocyte/macrophage line- age. It is reported that osteoclast precursors reside in human peripheral blood monocytes [4,5]. A marked increase of the circulating osteoclast ...
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LncRNA TUG1 was upregulated in osteoporosis and regulates the proliferation and apoptosis of osteoclasts
... Background: Long non-coding RNA (LncRNA) TUG1 plays critical roles in the development of human cancers. Its inhibition has been proved to participate in ankylosing spondylitis, which is an inverse pathological procedure ...
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Lack of effect of adenosine on the function of rodent osteoblasts and osteoclasts in vitro
... (TRAP). Osteoclasts were identified as TRAP-positive cells with ≥2 ...of osteoclasts and area resorbed per disc were evaluated ‘blind’ using transmitted and reflected light microscopy, as described ...
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Pro-osteoclastic In Vitro Effect of Polyethylene-like Nanoparticles: Involvement in the Pathogenesis of Implant Aseptic Loosening.
... Finally, osteoclast precursors enhanced osteoclast differentiation in a dose; and time; dependent manner after exposition to FPN. The growing upregulation of TRAP expression confirm the functional activation induced by ...
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Osteoclasts are essential for TNF α–mediated joint destruction
... For quantification of the areas of inflammation, H&E-stained sections (five per mouse) were evaluated. The sum of the areas of inflammation for each single mouse was calculated by evaluating all digital, carpal, and ...
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Regulation of sodium dependent phosphate transport in osteoclasts
... unpolarized osteoclasts cultured on glass ...polarized osteoclasts cultured on bone, immunofluorescence studies demonstrated the pro- tein to be localized exclusively on the basolateral membrane, where it ...
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HIV 1 replicates in human osteoclasts and enhances their differentiation in vitro
... human osteoclasts from CD14 + monocytes and examined them for their susceptibility to ...CD14-derived osteoclasts were shown to express CD4, CCR5, and CXCR4 each at the similar level to that shown with ...
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Cytoplasmic pH regulation and chloride/bicarbonate exchange in avian osteoclasts
... by osteoclasts during bone resorption. Our data show that osteoclasts possess a chloride/bicarbonate exchanger that enables them to maintain normal intracellular pH in the face of a significant proton ...
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Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts
... numerous osteoclasts, thus establishing that αvβ3 is not necessary for osteoclast ...more osteoclasts than do heterozygotes. These mutant osteoclasts are, however, dysfunctional, as evidenced by ...
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... in osteoclasts are αvβ3, αβ5, α2β1 and αβ1, out of which, αvβ3 has gained attention because it interacts with arginine, glycine, aspartic acid (RGD) containing peptides ...of osteoclasts, in endocytosis of ...
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“GLUCOCORTICOID INDUCED OSTEOPOROSIS” by Vijaya laxmi chiluka, David Banji, Otilia J.F Banji, Murali Sollu, Sonia Bindu Pandra, India.
... found. Osteoclasts release local factors from the bone during resorption which inhibit osteoclast function and stimulate osteoblast ...activity. Osteoclasts release factors that negative impact their ...
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Abstract: Bone homeostasis depends on the interplay between bone resporption by osteoclasts and
... MicroRNAs are a class of small non-coding RNA molecules (about 22-nucleotide long) that are involved in a wide range of physiological and pathological processes. It is evident in many recent studies that miRNAs affect ...
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Effects of osteoprotegerin from transfection of pcDNA3.1(+)/chOPG on bioactivity of chicken osteoclasts
... of osteoclasts was separated from chicken embryos and divided into three groups (control group, ...by osteoclasts was measured by the diazol ...of osteoclasts was evaluated by the area of lacunae on ...
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Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
... cate that osteoclasts in aberrant subchondral bone remodeling could be an important origin of OA pain. The various methods used to measure pain in this study are complementary. We exam- ined mechanical ...
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