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Pro-inflammatory mediators

Dual effects of noradrenaline on astroglial production of chemokines and pro-inflammatory mediators

Dual effects of noradrenaline on astroglial production of chemokines and pro-inflammatory mediators

... a pro-inflammatory stimulus, such as lipopolysaccharide (LPS) from gram-negative bacteria, which causes a large production of CX3CL1 by astrocytes, NA has the oppos- ite effect inhibiting CX3CL1 ...

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Heracleum moellendorffii roots inhibit the production of pro inflammatory mediators through the inhibition of NF κB and MAPK signaling, and activation of ROS/Nrf2/HO 1 signaling in LPS stimulated RAW264 7 cells

Heracleum moellendorffii roots inhibit the production of pro inflammatory mediators through the inhibition of NF κB and MAPK signaling, and activation of ROS/Nrf2/HO 1 signaling in LPS stimulated RAW264 7 cells

... treating inflammatory human diseases such as arthritis, backache and fever ...the pro-inflammatory mediators via the inhibition of MAPK signaling activation ...

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Expression of pro-inflammatory mediators is inhibited by an avocado/soybean unsaponifiables and epigallocatechin gallate combination

Expression of pro-inflammatory mediators is inhibited by an avocado/soybean unsaponifiables and epigallocatechin gallate combination

... anti- inflammatory drugs ...inhibit pro-inflammatory mediator production ...encoding pro-inflammatory mediators and matrix degrading enzymes are regulated by the transcription ...

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Effects of metformin on blood and urine pro-inflammatory mediators in patients with type 2 diabetes

Effects of metformin on blood and urine pro-inflammatory mediators in patients with type 2 diabetes

... with inflammatory responses ...chronic inflammatory responses play important roles in the pathogenesis of type 2 diabetes by causing islet dysfunction and insulin resistance in both inflammasome-dependent ...

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Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts

Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts

... multiple inflammatory signals via CREB-1 and NFκB signalling ...the inflammatory cascade of several stimuli, including TNFα-induced PAI-1 expression [36] and in LPS/TNFα stimulated macrophages ...

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Chinese herb pair Paeoniae Radix Alba and Atractylodis Macrocephalae Rhizoma suppresses LPS-induced inflammatory response through inhibiting MAPK and NF-κB pathway

Chinese herb pair Paeoniae Radix Alba and Atractylodis Macrocephalae Rhizoma suppresses LPS-induced inflammatory response through inhibiting MAPK and NF-κB pathway

... excessive pro-inflammatory mediators are mainly caused by activated transcriptional factors in the devel- opment of inflammation progress, among these regula- tions, NF-κB play an important role in ...

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Immunomodulatory effects of tick saliva on dermal cells exposed to Borrelia burgdorferi, the agent of Lyme disease

Immunomodulatory effects of tick saliva on dermal cells exposed to Borrelia burgdorferi, the agent of Lyme disease

... elicits pro-inflammatory mediator production by these ...certain pro-inflammatory mediators by these ...secrete pro- inflammatory mediators, yet inflammation may be ...

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Original Article Fucoidan attenuates atherosclerosis in LDLR mice through inhibition of inflammation and oxidative stress

Original Article Fucoidan attenuates atherosclerosis in LDLR mice through inhibition of inflammation and oxidative stress

... could reduce the local inflammation. Further- more, we found that the expression of SM-22, a SMC marker, was significantly attenuated by fucoidan, suggesting that the anti-atheroscle- rosis effects of fucoidan may ...

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Synthesis and pharmacological evaluation of the individual stereoisomers of 3  [methyl(1,2,3,4 tetrahydro 2 naphthalenyl)amino] 1 indanone, a potent mast cell stabilising agent

Synthesis and pharmacological evaluation of the individual stereoisomers of 3 [methyl(1,2,3,4 tetrahydro 2 naphthalenyl)amino] 1 indanone, a potent mast cell stabilising agent

... Previous work by Barlow and Walsh 9 described the synthesis and mast cell stabilising properties of a series of novel tetrahydronaphthalene based compounds. The most active molecule synthesised was the N-methylated ...

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PubMedCentral-PMC5334284.pdf

PubMedCentral-PMC5334284.pdf

... and pro-inflammatory gene expression was mainly caused due to TRIF pathway activation ...of pro-inflammatory mediators and adhesion molecules ...PAR-1-dependent ...

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Anti inflammatory effects of Phyllanthus amarus Schum  & Thonn  through inhibition of NF κB, MAPK, and PI3K Akt signaling pathways in LPS induced human macrophages

Anti inflammatory effects of Phyllanthus amarus Schum & Thonn through inhibition of NF κB, MAPK, and PI3K Akt signaling pathways in LPS induced human macrophages

... treat inflammatory diseases by inhibiting cyclooxygenase-2(COX-2) ...the inflammatory related diseases ...of pro-inflammatory mediators and the activation of signaling molecules related ...

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PubMedCentral-PMC5647777.pdf

PubMedCentral-PMC5647777.pdf

... bacterial pro-inflammatory mediators were significantly increased after saccharin consumption ...of pro-inflammatory cytokines like interleukin-6 or tumor necrosis factor (TNF)-α via ...

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Increased Inflammatory Response in Myocardial Ischemia-Reperfusion in Normal and STZ Induced Type I Diabetic Rats and Modulation of Inflammatory

Increased Inflammatory Response in Myocardial Ischemia-Reperfusion in Normal and STZ Induced Type I Diabetic Rats and Modulation of Inflammatory

... Exaggerated neutrophil accumulation in the diabetic hearts probably attributed to the enhanced activity of myeloperoxidase in diabetic hearts subjected to ischemia- reperfusion injury when compared to normal rats. ...

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Cholinesterase: Not a robust marker of systemic low-grade inflammation in hypertension

Cholinesterase: Not a robust marker of systemic low-grade inflammation in hypertension

... al., 2007; Mayeux, 2007) and atherosclerosis (Ridker et al., 1998; Kaur, 2013). Increased serum/plasma and other tissues BChE activity has been proposed as a marker of low grade systemic inflammation (Libby et al., ...

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PreImplantation Factor (PIF) promoting role in embryo implantation: increases endometrial Integrin-α2β3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua

PreImplantation Factor (PIF) promoting role in embryo implantation: increases endometrial Integrin-α2β3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua

... Prior to this study, it was not fully established how early embryo-maternal cross talk is initiated. We herein report for the first time, that PIF, an embryo-specific compound, has an important evolving role in uterine ...

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Mechanisms of eosinophil recruitment and degranulation

Mechanisms of eosinophil recruitment and degranulation

... The eosinophil is a proinflammatory leukocyte that is present in the circulation and in tissues in low levels in healthy individuals. In atopies, levels of this cell are markedly elevated and eosinophilic inflammation is ...

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Protective effect of vasoactive intestinal peptide on bone destruction in the collagen induced arthritis model of rheumatoid arthritis

Protective effect of vasoactive intestinal peptide on bone destruction in the collagen induced arthritis model of rheumatoid arthritis

... cytokines pro- duced by macrophages, fibroblasts and T cells of the synovial ...derived inflammatory cytokines such as IL-1 β and TNF α perpetuate inflammation in a paracrine ...such mediators in the ...

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The crosstalk between vascular MSCs and inflammatory mediators determines the pro-calcific remodelling of human atherosclerotic aneurysm

The crosstalk between vascular MSCs and inflammatory mediators determines the pro-calcific remodelling of human atherosclerotic aneurysm

... especially inflammatory and degenerative affections; the implications of the inflam- matory process, which arises in combination with ageing and during several human diseases, on MSC behaviour are reaching growing ...

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Severe exacerbations in moderate-to-severe asthmatics are associated with increased pro-inflammatory and type 1 mediators in sputum and serum

Severe exacerbations in moderate-to-severe asthmatics are associated with increased pro-inflammatory and type 1 mediators in sputum and serum

... Forty mediators in sputum supernatants, and 43 media- tors in serum were measured using the Meso Scale Dis- covery Platform (MSD® Gaithersburg, MD, USA) and enzyme-linked immunosorbent assay (ELISA) as de- scribed ...

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Pro resolving lipid mediators in vascular disease

Pro resolving lipid mediators in vascular disease

... Vascular injury and intimal hyperplasia. In settings of acute ves- sel injury such as angioplasty or bypass grafting, loss of endothelial integrity and damage to underlying VSMCs initiates a rapid response of platelets, ...

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