proliferator-activated receptor alpha
Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice
... Peroxisome proliferator activated receptor alpha (PPAR a ), interacts with the retinoid X receptor to func- tion as a transcription factor to induce the expression of a series of genes ...
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RECENT ADVANCES ON NOVEL DUAL ACTING PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AND GAMMA AGONISTS
... peroxisome proliferator- activated receptor alpha and gamma agonists: Given the favorable effects of fibrates on both lipid parameters and the hypoglycemic effects of PPAR-γ agonists, a dual ...
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Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice
... peroxisome proliferator activated receptor alpha; ConA: Concanava- lin A; IFNγ: interferon gamma; IL: interleukin; NKT: natural killer T cell; WT: wild type; AOX: acyl CoA oxidase; NFκB: ...
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EFFECT OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONISTS ON DIABETES INDUCED ACUTE KIDNEY INJURY: ROLE OF OXIDATIVE STRESS AND HYPERLIPIDEMIA
... Further, the growing glomerulosclerosis, thickening of the glomerular basement membrane, glomerular hypertrophy, mesangial cell expansion, podocyte loss, renal-cell hypertrophy, and tubulointerstitial fibrosis are major ...
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The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential
... In the era of precision medicine, treatments that target specific modifiable characteristics of high‑risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. ...
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Peroxisome proliferator-activated receptor-alpha gene, obesity, and breast cancer incidence and survival : a LIBCSP ancillary study
... Peroxisome proliferator-activated receptor-alpha (PPARA) has been shown to increase fatty acid oxidation and decrease cytokine levels, and has been implicated in insulin ...
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Pemafibrate (K-877), a novel selective peroxisome proliferator-activated receptor alpha modulator for management of atherogenic dyslipidaemia
... peroxisome proliferator‑activated receptor alpha (PPARα) agonists, (fibrates), but these have low potency and limited selectivity for ...unique receptor–cofactor binding profile to ...
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Di(2-ethylhexyl) phthalate-induced toxicity and peroxisome proliferator-activated receptor alpha: a review
... As mentioned above, although the expression of human PPAR is similar to that in rodents [13], it is less active against carcinogenesis than that in rodents [10, 14, 15]. However, factors other than PPAR have been ...
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Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice
... treatment and restored by WY14643 administration. OPN is a chemoattractant molecule engaged in the hepatic in- flammatory response by promoting neutrophil infiltration in the liver [12]. As a biomarker of fibrosis [13], ...
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SCREENING AND MOLECULAR DOCKING STUDIES OF NEW NATURAL AGONISTS AGAINST PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA TARGETED TO TREAT OBESITY
... Peroxisome proliferator- activated receptor (PPAR) was one among the major targets for obesity treatment has drawn attention in developing the new ...This receptor belongs to the nuclear ...
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Cyclin D1 represses peroxisome proliferator-activated receptor alpha and inhibits fatty acid oxidation
... peroxisome proliferator- activated receptor α (PPARα), a member of nuclear receptor family that induces fatty acid oxidation and may play an anti-neoplastic ...
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A gender related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator activated receptor alpha deficient mice
... Our results demonstrate the importance of PPARa in car- diac as well as hepatic metabolism. Several lines of published ev- idence indicate that PPARa is involved in the regulation of liver metabolism. PPAR a is required ...
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Effects of L-carnitine against oxidative stress in human hepatocytes: involvement of peroxisome proliferator-activated receptor alpha
... Methods: We analyzed cytotoxicity using MTT assay and lactate dehydrogenase (LDH) release. Antioxidant activity and lipid peroxidation were estimated by reactive oxygen species (ROS) levels, activities and protein ...
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Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma
... Introduction: Hepatocellular carcinoma (HCC) has a close relationship with lipid metabolism. Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the regulation of fatty acid ...
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Role of nuclear receptor-independent pathways in the mechanism of action of peroxisome proliferators
... nuclear receptor peroxisome proliferator activated receptor alpha (PPARα) ...This receptor is largely responsible for lipid metabolism through transcriptional regulation of fatty ...
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Peroxisome Proliferator-Activated Receptors (PPARS): A Target with a Broad Therapeutic Potential for Human Diseases: An Overview
... single receptor alone will elicit such a complex pleiotropic response but likely, rather, that other mediators are required for the changes in growth, lipid perturbation and peroxisome ...TNF alpha, is ...
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Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity
... peroxisome proliferator-activated receptors (PPARs) belong to a nuclear receptor (NR) superfamily of ligand- inducible transcription factors that form functional com- plexes with the retinoid × ...
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Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma
... peroxisome proliferator- activated receptor c (PPARc), CCAAT-/enhancer-binding protein a, sterol regulatory element-binding transcription factor 1c and fatty acid ...
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Activators of peroxisome proliferator activated receptor gamma have depot specific effects on human preadipocyte differentiation
... In contrast to preadipocytes from SC adipose tissue, Om preadipocytes are refractory to the differentiation-promoting effects of these compounds, indicating an intrinsic difference in susceptibility to PPAR g agonists ...
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Original Article The association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene with the metabolic characteristics in Chinese women with polycystic ovary syndrome
... expressed in adipose tissue, mediated an important function of PPARγ. A functional poly- morphism in exon 2 of PPARγ2, the Pro12Ala (rs1801282) [6], has been suggested Ala allele lowered the risk of type 2 diabetes with ...
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