Prostaglandin I2, PGI2.
Prostaglandin I2 is not a major metabolite of arachidonic acid in cultured endothelial cells from human foreskin microvessels
... Prostaglandin I2 (PGI2), a potent vasodilator and inhibitor of platelet aggregation, is a major product of arachidonic acid metabolism in endothelial cells that are derived from large blood vessels ...
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Variants in Human Prostacyclin Receptor Gene in Patients with Migraine Headache
... Prostaglandin I2 (PGI2 or prostacyclin) is a member of the eicosanoid family of lipid mediators produced mainly by endothelial cells and plays a role in primary hemostasis by inhibiting platelet ...
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Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta
... sufficient PGI2 to prevent platelet adherence and subsequent platelet- platelet ...synthesize PGI2. We have measured the concentrations of PGI2 synthase and prostaglandin endoperoxide (PGH) ...
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Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP
... PGI2 is produced by COX-2 and a selective inhibitor of this enzyme, SC-58125, also significantly reduced the increases in plasma renin activity and renin mRNA expression in WT mice with [r] ...
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Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents
... thrombin. PGI2 production by pig aortic endothelial cells cultured on microcarrier beads and perfused in columns was stimulated in a dose-dependent manner by trypsin, chymotrypsin, and cathepsin G (1-100 ...
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The effect of inhibition of prostaglandin synthesis on urinary sodium excretion in the conscious dog
... that prostaglandin inhibition in the conscious dog is associated with a natriuresis without a change in urinary volume or potassium excretion during water ...
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Selective Binding Site for [3H]Prostacyclin on Platelets
... Prostacyclin (PGI 2 ) is the most potent, naturally occurring inhibitor of platelet aggregation known. To determine whether PGI 2 is bound by platelets, high specific activity [9- 3 H]PGI 2 was synthesized by iodination ...
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Alomair
... During the past few decades, extensive researches were conducted to identify serological markers in patients with inflammatory bowel disease (IBD) that can reliably diagnose and monitor disease activity and help in ...
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(Polyvinyl Alcohol-Iodine) Bio-Composites and Their Applications
... injured mice , were mice were divided in three groups( each group with five mice) to monitor this effect. The first group (a) considered as negative control (without treatment) and the second group (b) as a positive ...
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Solanaceae Evolutionary Dynamics of the I2 NBS Domain
... the I2 resistance gene sequences. Thirty-three new candidate homologues I2 resistance gene nucleotide se- quence were obtained from wild tomato ...in I2-NBS domain was detected in wild tomato ...
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Gaming Tables and I.G., I2, 324
... " damage " at the edge for eleven lines and eradicate sixteen letter-spaces. But in antiquity, as today, marble was transported from the quarry rough-hewn. Blocks in[r] ...
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Two New Fragments of I.G. I2, 233
... The uninscribed portion at the top of the new fragment will be the uninscribed ends of two lines plus part of a line left vacant between the body of the inventory and the [r] ...
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[Phthalocyaninato(2–)]arsenic(III) triiodide
... than the central iodine (I1). This interaction correlates well with the charge on the I atoms (ÿ0.419 on both terminal I atoms and ÿ0.163 on the central I atom) calculated by Landrum et al. (1997). The As I3 (terminal) ...
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<p>Prostaglandins as the Agents That Modulate the Course of Brain Disorders</p>
... Abstract: Neurologic and neuropsychiatric diseases are associated with great morbidity and mortality. Prostaglandins (PGs) are formed by sequential oxygenation of arachidonic acid in physiologic and pathologic ...
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I.G., I2, 95, and the Ostracism of Hyperbolus
... In any conciliar year the out- going prytany drew lots to determine its successor, so that no prytany could be identi- fied in advance with any tribe, save in the ninth prytany, wh[r] ...
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Cultured endothelial cells synthesize both platelet activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate
... induced PGI2 synthesis: stimulation of a histamine H1 or a bradykinin B2 receptor induced both PAF and PGI2 ...and PGI2 by endothelial cells. The synthesis of PGI2 proceeded for only ...
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Episode-Specific Differential Gene Expression of Peripheral Blood Mononuclear Cells in Rapid Cycling Supports Novel Treatment Approaches
... in prostaglandin metabolism might give clues to potential treatment targets, but to confirm their general relevance in bipolar disease, more patients will have to be examined for cycling-associated al- terations ...
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Beraprost Sodium, a Prostaglandin I2 Analogue, Protects Against Advanced Glycation End Products-induced Injury in Cultured Retinal Pericytes
... Background: Beraprost sodium, a prostaglandin I2 ana- logue, has been recently reported to exhibit beneficial effects on atherosclerosis in patients with diabetes. However, effects of beraprost sodium on ...
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Lipopolysaccharide induces prostaglandin H synthase 2 protein and mRNA in human alveolar macrophages and blood monocytes
... We and others have previously demonstrated that human alveolar macrophages produce more PGE2 in response to lipopolysaccharide (LPS) than do blood monocytes. We hypothesized that this observation was due to a greater ...
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Cardiac and Renal Prostaglandin I2: BIOSYNTHESIS AND BIOLOGICAL EFFECTS IN ISOLATED PERFUSED RABBIT TISSUES
... prostaglandin (PG) I 2 . The evidence that supports this finding includes: (a) radiochemical identification of the stable end-product of PGI 2 , 6-keto-PGF 1a , in the venous effluent after arachidonic acid ...
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