prostaglandin I2 (prostacyclin)
Beraprost Sodium, a Prostaglandin I2 Analogue, Protects Against Advanced Glycation End Products-induced Injury in Cultured Retinal Pericytes
... Beraprost sodium is a newly developed orally active prostaglandin I2 analogue with antiplatelet and vasodilating properties (1). Recently, beraprost sodium has been reported to exhibit beneficial effects on ...
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Prostaglandin I2 is not a major metabolite of arachidonic acid in cultured endothelial cells from human foreskin microvessels
... Prostaglandin I2 (PGI2), a potent vasodilator and inhibitor of platelet aggregation, is a major product of arachidonic acid metabolism in endothelial cells that are derived from large blood vessels ...for ...
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Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents
... The effects of neutrophil elastase on endothelial prostacyclin PGI2 production, nucleotide release, and responsiveness to vasoactive agents were compared with the effects of cathepsin G [r] ...
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Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta
... Platelets adhere to the subendothelial layer of newly deendothelialized arteries. Attachment can be reduced with exogenous prostacyclin (PGI2). Thus, the subendothelium may be unable to produce sufficient PGI2 to ...
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Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP
... PGI2 is produced by COX-2 and a selective inhibitor of this enzyme, SC-58125, also significantly reduced the increases in plasma renin activity and renin mRNA expression in WT mice with [r] ...
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Cardiac and Renal Prostaglandin I2: BIOSYNTHESIS AND BIOLOGICAL EFFECTS IN ISOLATED PERFUSED RABBIT TISSUES
... prostaglandin (PG) I 2 . The evidence that supports this finding includes: (a) radiochemical identification of the stable end-product of PGI 2 , 6-keto-PGF 1a , in the venous effluent after arachidonic acid ...
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Variants in Human Prostacyclin Receptor Gene in Patients with Migraine Headache
... Objective: Prostaglandin I2 receptor plays a major physiologic role in the relaxation of arterial smooth muscle and vasodilation and possibly during migraine ...of Prostaglandin I2 receptor ...
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Effect of Prostaglandin I2 Analogs on Cytokine Expression in Human Myeloid Dendritic Cells via Epigenetic Regulation
... Prostaglandin I 2 (PGI 2 ) analog is regarded as a potential candidate for treating asthma. Human myeloid dendritic cells (mDCs) play a critical role in the pathogenesis of asthma. However, the effects of PGI 2 ...
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Thrombogenic Effect of High Dose Aspirin in Rabbits: RELATIONSHIP TO INHIBITION OF VESSEL WALL SYNTHESIS OF PROSTAGLANDIN I2 LIKE ACTIVITY
... vessel wall using the thrombin-induced [ 14 C]serotonin release assay. A 200-mg/kg dose of aspirin significantly augmented thrombus size when compared to (a) sodium salicylate administered in equal doses, (b) aspirin in ...
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Statins stimulate arachidonic acid release and prostaglandin I2 production in rat liver cells
... Statins inhibit 3-hydroxy-3-methylglutaryl (HMG-CoA) reductase, the rate limiting step in cholesterol synthesis. They are, therefore, used clinically to lower cholesterol and prevent atherosclerosis. Statins have ...
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A Role for Prostacyclin in Bruising Symptomatology
... with the length of the bleeding time in several previous studies,79 At the same time, blood pressure (using a size-appropriate sphyng- momanometer cuff), hemoglobin levels, hematocrit, w[r] ...
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The effect of inhibition of prostaglandin synthesis on urinary sodium excretion in the conscious dog
... prostaglandin inhibitor did not alter glomerular filtration rate, renal plasma flow, urinary volume, or potassium excretion. Sodium excretion, however, increased from 32 to 130 mueq/min (P less than 0.02). ...
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(Polyvinyl Alcohol-Iodine) Bio-Composites and Their Applications
... with PVA/I2 looked smaller and the wound healing was better and the skin returned to its normal color, light pink to in picture (c), while the wounds appeared in the animals group of B are still in the coagulation ...
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Solanaceae Evolutionary Dynamics of the I2 NBS Domain
... in I2 genes in the Solanaceae family. We identified putative I2 orthologues in several Sola- naceae species hosts of ...the I2 tree reflect Solanaceae species division ...the I2 functional ...
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Increased hydrolysis of cholesteryl ester with prostacyclin is potentiated by high density lipoprotein through the prostacyclin stabilization
... We present herein data showing that PGI2 with HDL can significantly maintain high levels of intracellular cAMP in cultured intact arterial smooth muscle cells SMC, and that this enhancem[r] ...
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Two New Fragments of I.G. I2, 233
... The uninscribed portion at the top of the new fragment will be the uninscribed ends of two lines plus part of a line left vacant between the body of the inventory and the [r] ...
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Alomair
... Over time, Chron’s disease can evolve and progress from an inflammatory non-stricturing and non-fistulizing phenotype to aggressive structuring or penetrating phenotypes. Such progression was found to be positively ...
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[Phthalocyaninato(2–)]arsenic(III) triiodide
... than the central iodine (I1). This interaction correlates well with the charge on the I atoms (ÿ0.419 on both terminal I atoms and ÿ0.163 on the central I atom) calculated by Landrum et al. (1997). The As I3 (terminal) ...
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<p>Prostaglandins as the Agents That Modulate the Course of Brain Disorders</p>
... Abstract: Neurologic and neuropsychiatric diseases are associated with great morbidity and mortality. Prostaglandins (PGs) are formed by sequential oxygenation of arachidonic acid in physiologic and pathologic ...
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Endogenous prostaglandin endoperoxides and prostacyclin modulate the thrombolytic activity of tissue plasminogen activator Effects of simultaneous inhibition of thromboxane A2 synthase and blockade of thromboxane A2/prostaglandin H2 receptors in a canine model of coronary thrombosis
... To determine whether these mechanisms might affect the thrombolytic activity of t-PA and the incidence of reocclusion after thrombolysis, we compared the effects of simultaneous inhibiti[r] ...
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