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protein degradation cell homeostasis

Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes

Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes

... mitogen-activated protein kinase (MAPK)- dependent cascade that promotes differentiation of the enclosed germ cells (Kiger et ...TA cell divisions, the initiation of Bam expression terminates mitotic ...

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The synaptic maintenance problem: membrane recycling, Ca2+homeostasis and late onset degeneration

The synaptic maintenance problem: membrane recycling, Ca2+homeostasis and late onset degeneration

... the degradation of protein aggregates ...after cell-specific deletion of atg7 in dopa- minergic neurons ...through degradation of the E3 ubiquitin ligase highwire ...individual protein ...

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Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice

Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice

... acinar cell vacuolization and death, interstitial fibrosis, inflammation, and circulatory release of pancreatic enzymes, clinical signs resembling those of human chronic ...autophagic protein ...

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Functional phosphatome requirement for protein homeostasis, networked mitochondria, and sarcomere structure in C  elegans muscle

Functional phosphatome requirement for protein homeostasis, networked mitochondria, and sarcomere structure in C elegans muscle

... cytosolic protein degradation, we functionally clustered the genes identi fi ed as required to prevent induction of pro- tein degradation into those appearing to be required to pre- vent autophagy or ...

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Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line

Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line

... RNA-binding protein Csde1 (Cold shock domain protein e1) is strongly upregulated during erythropoiesis compared to other hematopoietic ...and protein degradation, but also proteins associated ...

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Inducible Protein Dimerization: New Tools and Applications to Understanding the Mitotic Checkpoint

Inducible Protein Dimerization: New Tools and Applications to Understanding the Mitotic Checkpoint

... choreographed interactions between dozens or hundreds of proteins carefully organized in time and space. In order to test hypotheses about complex cellular functions, it is desirable to experimentally perturb the ...

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Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).

... more protein targets are modulated and additional crystallographic evidence of the target protein/E3 ligase/PDP ternary complexes are ...selective degradation probe that eliminates pirin at low ...

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USP7 is a novel Deubiquitinase sustaining PLK1 protein stability and regulating chromosome alignment in mitosis

USP7 is a novel Deubiquitinase sustaining PLK1 protein stability and regulating chromosome alignment in mitosis

... PLK1 is a master mitotic regulator controlling a wide variety of processes during G2/M cell cycle progression, such as centrosome maturation, entry into mitosis, chromosome segregation and cytokinesis. In ...

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An Updated Review On Anticancer Activity Of Capsaicin

An Updated Review On Anticancer Activity Of Capsaicin

... induced cell cycle arrest and apoptosis in human esophagus epidermoid carcinoma CE 81T/VGH cells through the elevation of intracellular reactive oxygen species and Ca2+ productions and caspase-3 ...

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Ubiquitin conjugating enzyme involved in the immune response caused by pathogens invasion

Ubiquitin conjugating enzyme involved in the immune response caused by pathogens invasion

... or degradation of host proteins, virus plunders and exploits substrate for the proliferation of progeny ...in cell. As a significant pathway of protein degradation, UPP is al- ways utilized by ...

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Berschneider, Korbinian
  

(2016):


	Connecting the functions of the proteasome and mitochondria in the lung.


Dissertation, LMU München: Medizinische Fakultät

Berschneider, Korbinian (2016): Connecting the functions of the proteasome and mitochondria in the lung. Dissertation, LMU München: Medizinische Fakultät

... the cell and proteasomes are a huge ATP-consuming ...monophosphate-activated protein kinase (AMPK) or protein kinase A (PKA) can induce posttranslational modifications of the proteasome and thereby ...

161

T cell homeostasis and systemic autoimmunity

T cell homeostasis and systemic autoimmunity

... T cell expansion until the T cell pool is reestablished to a nearly normal ...T cell proliferation may, depending on additional background genes, contribute to systemic autoimmune disease ...T ...

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Serine phosphorylation regulates paxillin turnover during cell migration

Serine phosphorylation regulates paxillin turnover during cell migration

... for cell migration ...by cell adhesion on fibronectin [21] or vitronectin ...during cell mitosis, which is associated with an absence of adhesive complexes, paxillin serine phosphor- ylation ...

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Pkm2 is a target of huhs1015 for inducing colonic cancer cell death

Pkm2 is a target of huhs1015 for inducing colonic cancer cell death

... PKM2 protein mainly due to autopahgic ...of degradation of macromolecules such as proteins and organelle in the cytoplasm, and impaired autophagy causes a variety of disorders including cancer and metabolic ...

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The syndecan family of proteoglycans  Novel receptors mediating internalization of atherogenic lipoproteins in vitro

The syndecan family of proteoglycans Novel receptors mediating internalization of atherogenic lipoproteins in vitro

... auxiliary cell-sur- face molecules that then mediate internalization (6, 34), al- though, as noted above, this process may require conforma- tional changes in the ligands or ...ligands, cell types, HS side ...

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RND3 promotes Snail 1 protein degradation and inhibits glioblastoma cell migration and invasion

RND3 promotes Snail 1 protein degradation and inhibits glioblastoma cell migration and invasion

... However, emerging evidence has suggested that other regulatory signaling pathways are also involved in RND3-mediated regulations. In esophageal squamous cells, forced expression of RND3 suppresses cell migration ...

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The Abundant Tegument Protein pUL25 of Human Cytomegalovirus Prevents Proteasomal Degradation of pUL26 and Supports Its Suppression of ISGylation

The Abundant Tegument Protein pUL25 of Human Cytomegalovirus Prevents Proteasomal Degradation of pUL26 and Supports Its Suppression of ISGylation

... (Waters). Protein identifications were obtained by searching a custom- compiled database containing sequences of human and HCMV proteins from the UniProt ...valid protein identification, the following ...

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PIP degron stabilized Dacapo/p21Cip1 and mutations in ago act in an anti  versus pro proliferative manner, yet both trigger an increase in Cyclin E levels

PIP degron stabilized Dacapo/p21Cip1 and mutations in ago act in an anti versus pro proliferative manner, yet both trigger an increase in Cyclin E levels

... Dap protein showing the amino acid residues mutated and tested in the UAS transgenes, from top to bottom (see Table S1 for a complete list of UAS ...daughter cell (PH3-positive, Dpn-negative, ...

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The Prognostic Impact of Heat Shock Proteins Expression in Patients with Esophageal Cancer: A Meta Analysis

The Prognostic Impact of Heat Shock Proteins Expression in Patients with Esophageal Cancer: A Meta Analysis

... not been published, which leading to unavoidable publication bias. Second, this meta-analysis was limited to English articles, which leading to potential language bias. Third, studies enrolled in our meta-analysis used ...

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Function of metal ion homeostasis in the cell division cycle, mitochondrial protein processing, sensitivity to mycobacterial infection and brain function

Function of metal ion homeostasis in the cell division cycle, mitochondrial protein processing, sensitivity to mycobacterial infection and brain function

... al. 1993) have shown that the permeability of the blood–brain barrier to Fe–transferrin is similar to that of albumin. The experiments suggested that the uptake of iron into the brain involves the transport of iron from ...

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