proteinase-activated receptor
Effect of Pertussis Toxin and Herbimycin A on Proteinase Activated Receptor 2 Mediated Cyclooxygenase 2 Expression in Helicobacter pylori Infected Gastric Epithelial AGS Cells
... cancer. Proteinase-activated receptor 2 (PAR2), subgroup of G-protein coupled receptor family, is highly expressed in gastric cancer, and chronic expression of cyclooxygenase-2 (COX-2) plays ...
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Proteinase-activated receptor-2: two potential inflammatory mediators of the gastrointestinal tract in Atlantic salmon
... Proteinase-activated receptor 2 (PAR-2), activated by trypsin and other serine proteinases, is a key initiator of inflammatory responses in the intestine of ...
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Essential role for proteinase activated receptor 2 in arthritis
... in proteinase-activated receptor-2 (PAR-2) as a mediator of neurogenic inflammation (1) and nociception ...tein–coupled receptor that is rapidly desensitized fol- lowing activation, PAR-2 is ...
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Essential role for proteinase-activated receptor-2 in arthritis
... in proteinase-activated receptor-2 (PAR-2) as a mediator of neurogenic inflammation (1) and nociception ...tein–coupled receptor that is rapidly desensitized fol- lowing activation, PAR-2 is ...
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Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5
... protein-coupled receptor proteinase- activated receptor 2 (PAR2), the latter of which functions as a cell-surface sensor for serine proteinases asscociated with the tumour ...
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Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology
... processes. Proteinase-activated receptor 2 (PAR2) is activated by speci fi c serine proteases (eg, matriptase 1 ), which mediates signalling ...
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Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour
... Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains ...
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Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4)
... Due to the irreversible nature of activation of PARs, for responsiveness to agonist to be retained, fresh supplies of receptor are required to be mobilized to the cell surface. Deliv- ery to the membrane requires ...
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The proteinase activated receptor 2 (PAR 2) mediates mitogenic responses in human vascular endothelial cells
... bin (Fig. 9 B). This effect was time dependent, displaying a more pronounced inhibition after a 16-h incubation as com- pared to the effect seen at four h. Indeed the 4-h response was near maximal, but clearly delayed, ...
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Trypsin activates pancreatic duct epithelial cell ion channels through proteinase activated receptor 2
... trypsin cleavage site. Despite the lack of information about the sequence of canine PAR-2, residues around the trypsin cleavage site are highly conserved in mouse, rat, and human (6, 8, 27). Although we cannot exclude ...
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Combined upregulation of matrix metalloproteinase-1 and proteinase-activated receptor-1 predicts unfavorable prognosis in human nasopharyngeal carcinoma
... collagenase activity of MMP-1 has long been associated with tumor growth, invasion, and metastasis by its dual functions of both modifying the matrix and promoting vessel formation. In addition, recent studies have ...
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Mast cell tryptase regulates rat colonic myocytes through proteinase activated receptor 2
... Our results indicate that PAR-2 is highly expressed by co- lonic muscle and that mast cell tryptase potently activates PAR-2 on isolated myocytes. Although tryptase did not inhibit motility of strips of colon, other ...
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Proteinase-activated receptor 2 and disease biomarkers in cerebrospinal fluid in cases with autopsy-confirmed prion diseases and other neurodegenerative diseases
... Greatly increased T-tau levels, decreased disease duration and age at death as well as a positive protein 14-3-3 status were significantly associated with prion diseases.. Values of T-ta[r] ...
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Activation of proteinase activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study
... antibodies against extracellular signal-regulated kinase 1/2 (Erk1/2), p38, JNK (c-jun N-terminal kinase), and NF-κB in the presence or absence of the PAR-2-AP and/or IL-1β. PAR-2- induced MMP and COX-2 levels in ...
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Proteinase-activated receptor 4 stimulation-induced epithelial-mesenchymal transition in alveolar epithelial cells
... Background: Proteinase-activated receptors (PARs; PAR 1–4 ) that can be activated by serine proteinases such as thrombin and neutrophil catepsin G are known to contribute to the pathogenesis of ...
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Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation
... Administration of PAR peptide agonists into the urinary bladder of mice elicited an inflammatory reaction charac- terized by edema and granulocyte infiltration. Interest- ingly, the inflammatory responses to PAR4-AP ...
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A role for proteinase activated receptor–1 in inflammatory bowel diseases
... receptors activated by the proteolytic cleavage of their N-terminal extracellular domain (1, ...the receptor-tethered ligand domain can selectively activate PARs, providing useful phar- macological tools to ...
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Sensitization of ASIC3 by proteinase-activated receptor 2 signaling contributes to acidosis-induced nociception
... Acid-sensing ion channels (ASICs) are proton-gated cat- ion channels which are activated by extracellular pH fall. To date, at least six ASIC subunits encoded by four genes have been identified in mammals [19]. ...
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Anti-Inflammatory mechanisms of the proteinase-activated receptor 2-inhibiting peptide in human synovial cells
... serine protease-mediated cleavage of the N-terminus of the receptors [8,9]. Mounting evidence indicated that trypsin cleaves PAR-2 at R 34 ↓S 35 LIGKV (in human) to expose a hexameric-tethered peptide that binds to con- ...
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Proteinase-activated receptors (PARs) – focus on receptor-receptor-interactions and their physiological and pathophysiological impact
... of activated B-cells; NMDA: N-methyl-D-aspartate; NLR: NOD-like receptor, nucleotide oligomerization domain receptor; P2X1 receptor: ATP-gated cation channel; P2Y12: Purinergic receptor ...
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