Proteinase Inhibitor
Rhabdovirus-induced apoptosis in a fish cell line is inhibited by a human endogenous acid cysteine proteinase inhibitor.
... cysteine proteinase inhibitor (ACPI; also termed cystatin A), isolated from human palatine tonsils, inhibited SVCV-induced apoptosis in EPC cells without reducing the growth of the ...
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Interaction of mouse macrophage elastase with native and oxidized human alpha 1 proteinase inhibitor
... Native and oxidized alpha 1-proteinase inhibitor (alpha 1-PI) were compared as substrates for the metalloproteinase macrophage elastase. At substrate concentrations at which native alpha 1-PI was readily ...
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Proteolytic inactivation of alpha 1 proteinase inhibitor by a neutrophil metalloproteinase
... Human neutrophils triggered with phorbol myristate acetate or opsonized zymosan particles released a metalloproteinase (MP) capable of cleaving and inactivating alpha-1-proteinase inhibitor (alpha-1-PI). ...
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Original Article Overexpression of proteinase inhibitor 9 is associated with poor prognosis in human hepatocellular carcinoma and with proliferation and apoptosis in HepG2 cells in vitro
... Abstract: Excessive proteinase inhibitor 9 (PI9) levels predict a poor outcome for patients with several tumor types. We compared the expression of PI9 in HepG2 cells and in 21 pairs of tumor and peritumor ...
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Plasma levels of elastase specific fibrinopeptides correlate with proteinase inhibitor phenotype Evidence for increased elastase activity in subjects with homozygous and heterozygous deficiency of alpha 1 proteinase inhibitor
... There is indirect evidence that unopposed human neutrophil elastase (HNE) is responsible for emphysema in patients with alpha 1-proteinase inhibitor (Pi) deficiency. To directly explore this possibility, we ...
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Structure function study of a plant protein proteinase inhibitor: site directed mutagenesis of Cucurbita maxima trypsin inhibitor V
... The structure of CMTI-V is also known and is similar to structures of other serine proteinase inhibitors of the Potato I family, e.g., chymotrypsin inhibitor from barley McPhalen and Jam[r] ...
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Pulmonary deposition and clearance of aerosolized alpha 1 proteinase inhibitor administered to dogs and to sheep
... Values for plasma Al PI clearance 0.751±0.154 ml * kg-' * h-' unpublished data and steady state volume of distribution 99.9±21.0 ml/kg 14 in dogs were used with the measured plasma Al PI[r] ...
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Hypersensitivity Vasculitis with Leukocytoclastic Vasculitis Associated with Alpha-1-Proteinase Inhibitor
... Prolastin is a commercially available form of alpha-1-antitrypsin (AAT) that is derived from pooled human plasma and used for treatment of severe alpha-1-antitrypsin deficiency (AATD).. [r] ...
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Oxidative regulation of neutrophil elastase alpha 1 proteinase inhibitor interactions
... Our results demonstrate that a neutrophils triggered in the presence of an excess of either purified a- 1-PI, serum, or bronchoalveolar lavage BAL fluid can directly accumulate and maint[r] ...
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Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex
... SLPI is an efficient inhibitor of NE and other serine protei- nases[1,2] and is found in high concentrations in secre- tions such as respiratory mucus[3]. In vitro it has antibacterial [4-6] and antifungal[7] ...
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A lymphokine regulates expression of alpha 1 proteinase inhibitor in human monocytes and macrophages
... In either case, the factor present in supernatants of mitogen-stimulated peripheral blood mononuclear cells independently regulates the expression of a1PI, since only the native 55,000-m[r] ...
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On the Activities of Pancreatic Proteases and Alpha 1 Proteinase Inhibitor in Meat Type Chicken
... Since 7 to 35 days of age A1PI concentration was nearly constant, serum trypsin concentration decreased while proteolytic activity in pancreatic tissue exhibited undulate increase; 2 Pro[r] ...
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Expression of human α1-proteinase inhibitor in Aspergillus niger
... recombinant inhibitor during growth, the following changes were implemented: (a) a protease-deficient mutant D15#26 was used for transfor- mation (instead of AB4-1), and (b) the pH of the superna- tants was ...
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Recombinant Cystatin-Like Thiol Proteinase Inhibitor (rCTPI) of Cicer arietinum (Chickpea): A potential source of Bio-pesticide.
... cysteine proteinase inhibitors (CPIs) or thiol proteinase inhibitors (TPIs) belonging to the superfamily of evolutionary, structurally and functionally related proteins involved in the inhibition of papain ...
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Search | Preprints
... Selected regions of replicate blot lanes from anion exchange isolated ovine cartilage SPIs were cut into regions corresponding to the 120, 58, 36 and 12 kDa SPI bands and examined using antibodies to the chondroitin-4 ...
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Physico-Chemical and Antifungal Properties of Trypsin Inhibitor from the Seeds of Mucuna Pruriens
... trypsin inhibitor from Lupinus albus seeds which consisted of a single polypeptide chain having a molecular weight of 6 ...like proteinase inhibitor from the seeds of Opuntia sterptacantha which ...
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... a 1 -Proteinase Inhibitor Therapy for the Prevention of Chronic Lung Disease of Prematurity: A Randomized, Controlled Trial.. Joseph A.[r] ...
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The multiple proteolytic enzymes of two microsporum species : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Microbiology at Massey University
... The aspartic proteinase inhibitor PEP also caused high inhibition unlike its action on azocollytic activity, which suggests M.canis produces one or more aspartic proteinases in the mix o[r] ...
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An alpha 2 macroglobulin receptor dependent mechanism for the plasma clearance of transforming growth factor beta 1 in mice
... Abstract Radioiodinated transforming growth factor-,61 TGF-,i1 bound to the plasma proteinase inhibitor, a2-macroglobulin a2M, as determined by chromatography on Superose-6 and native po[r] ...
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Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME)-2: the study protocol for a multi-centre, randomised, placebo-controlled trial
... Kallistatin is a serine proteinase inhibitor, known to be expressed in endothelial cells and vascular smooth muscle cells.33 Overexpression of human kallistatin in rodent models has been[r] ...
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