Protoporphyrin IX (PP-IX)
Apoptosis of THP-1 macrophages induced by protoporphyrin IX-mediated sonodynamic therapy
... Background: Sonodynamic therapy (SDT) was developed as a localized ultrasound-activated cytotoxic therapy for cancer. The ability of SDT to destroy target tissues selectively is especially appealing for atherosclerotic ...
8
μ Oxo bis[(protoporphyrin IX dimethyl ester)iron(III)]
... The -oxo dimer of iron protoporphyrin IX (FePPIX) is relevant in biology. For example, the black pigment of Porphyromonas gingivalis, a principal agent in adult perio- dontitis, has been identi®ed as the ...
19
Light harvesting in silicon(111) surfaces using covalently attached protoporphyrin IX dyes
... paper, Protoporphyrin IX was chosen due to the commercial availability, ease of functionalisation and shifting of the absorption and emission maxima by coordination with metal ...
6
Modelling topical photodynamic therapy treatment including the continuous production of Protoporphyrin IX
... Most existing theoretical models of photodynamic therapy (PDT) assume a uniform initial distribution of the photosensitive molecule, Protoporphyrin IX (PpIX). This is an adequate assumption when the prodrug ...
19
Carbon dot-protoporphyrin IX conjugates for improved drug delivery and bioimaging
... CA-EDA CDs were synthesized utilising 5 g of citric acid and 1.25 g of EDA dissolved in 100 ml of deionized water and stirred until no visible precipitate remained. This process was repeated for S-EDA CDs with 5 g of ...
22
Light harvesting in silicon(111) surfaces using covalently attached protoporphyrin IX dyes
... roughness of the surface. Multiple readings (on three different spots) were taken from each sample and averaged over all consistent measurements in order to minimise errors in the thickness measurements. There was no ...
25
In-vivo kinetics of inhaled 5-Aminolevulinic acid-Induced Protoporphyrin IX fluorescence in bronchial tissue
... The detection of premalignant and early-malignant endo- bronchial alterations is growing increasingly important in the diagnosis of lung cancer, since an acceptable progno- sis is strictly confined to the early stage of ...
7
Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway
... Among the tumor-specific fluorescent probes used for FGS, 5-Aminolevulinic acid (5-ALA) is the front-runner for tumor-normal border detection with a good safety profile and minimal side effects [4–6]. 5-ALA is a small ...
13
Zinc Protoporphyrin IX Binds Heme Crystals to Inhibit the Process of Crystallization in Plasmodium falciparum
... zinc protoporphyrin IX, normally present at ...zinc protoporphyrin IX inhibition of heme crystallization similar to the antimalarial ...Zinc protoporphyrin IX neither forms ...
8
A quantitative study of in vivo protoporphyrin IX fluorescence build up during occlusive treatment phases
... Background: Topical photodynamic therapy (PDT) is a non-invasive light based ther- apy used to treat non-melanoma skin cancer (NMSC) and dysplasia. During PDT, the light sensitive molecule protoporphyrin IX ...
20
Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells
... Results: By employing a drug repurposing approach, we found that protoporphyrin IX (PpIX), a metabolite of ami‑ nolevulinic acid applied in photodynamic therapy of cancer, stabilizes T[r] ...
12
Action of protoporphyrin IX (PP IX) in the lifespan of Drosophila melanogaster deficient in endogenous antioxidants, Sod and Cat
... According to the effect of PP-IX on both the wild type CS and the Cat strain, we suggest three possible mechanisms of action: a as inductor of the antioxidant enzymes to achieve normal l[r] ...
7
Factors affecting amninolaevulinic acid-induced generation of protoporphyrin IX
... The aims of this study are: 1 to investigate whether there is production and accumulation of PPIX by vascular endothelial and smooth muscle cells on exposure to ALA and whether this lead[r] ...
8
In Vitro Culture of Shell Gland Epithelial Cells in Japanese Quail (Coturnix coturnix japonica)
... DOI: 10.4236/ojas.2018.82013 185 Open Journal of Animal Sciences surface 3.5-2hours before oviposition [6] [9] [10]. The ovulatory process, possi- bly the preovulatory surge of gonadotropin(s) or progesterone, and ...
7
Stem Cell Transplantation Increases Antioxidant Effects in Diabetic Mice
... cobalt-protoporphyrin IX in recipient mice before conditioning and bone marrow transplantation (BMT) results in a reduction of GVHD and improved sur- vival ...
10
Oil components modulate the skin delivery of 5-aminolevulinic acid and its ester prodrug from oil-in-water and water-in-oil nanoemulsions
... Abstract: The study evaluated the potential of nanoemulsions for the topical delivery of 5-aminolevulinic acid (ALA) and methyl ALA (mALA). The drugs were incorporated in oil-in-water (O/W) and water-in-oil (W/O) ...
12
Porphyrin magnetite nanoconjugates for biological imaging
... acid protoporphyrin (protoporphyrin IX) was reacted with 3- aminopropyltriethoxysilane (3-APTES) under inert con- ditions in the presence of the carbodiimide coupling agent (EDCI) to form an amide ...
12
Synthetic Porphyrinic Macrocycles for Photodynamic Therapy and Other Biological Applications
... Protoporphyrin IX and its metal derivatives have been used as photosensitizers in photodynamic therapy (PDT) for the treatment of ...Cobalt protoporphyrin IX (CoPPIX), which is a synthetic ...
173
1201.pdf
... The active site of cytochrome P-450 contains a single iron protoporphyrin IX prosthetic group, and it is here that dioxygen is bound, reduced and activated. An overview of its catalytic cycle is shown in ...
70
Review of Studies on the Last Enzymes in Bacteriochlorophyll (Bchl) and Chlorophyll (Chl) Biosynthesis
... from protoporphyrin IX to Chl begins with the insertion of the Mg 2+ ion ...“magnesium- protoporphyrin methyltransferase” esterifies the propionic side chain of ring C in preparation for the ...
13