PTCL-Peripheral T cell lymphomas
Immunophenotyping of Nodal Peripheral T-cell Lymphomas and its Association with Epstein-Barr Virus
... nodular PTCL, maximally in ALCL-ALK positive cases ...null cell variant of ...null cell ALCL-ALK positive ...nodal PTCL samples and in all subgroups except in PTCL-NOS, where CD4+/CD8+ ...
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Hematologic toxicity is rare in relapsed patients treated with belinostat: a systematic review of belinostat toxicity and safety in peripheral T-cell lymphomas
... Abstract: Peripheral T-cell lymphomas (PTCLs) are an aggressive and diverse group of lymphomas with a T-cell ...relapsed PTCL and included a total of 144 ...
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Bendamustine for the treatment of relapsed or refractory peripheral T cell lymphomas: A French retrospective multicenter study
... Peripheral T cell lymphoma (PTCL) is a heterogeneous group of diseases, representing 10-15% of ...Most PTCL have aggressive forms with poor prognosis ...anaplastic-large cell ...
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Original Article Histological type distribution and expression of nm23, VEGF, TOP2A and MUM-1 in peripheral T-cell and NK-cell lymphomas in Chinese: analysis of 313 cases
... of T-cell rearrangements in our study showed ...from T-cells rather than NK-cells ...renal cell carcinoma [14, ...of PTCL-NOS overex- pressed nm23-H1 and its expression could be an ...
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New developments in the treatment of peripheral T-cell lymphoma – role of Belinostat
... Abstract: Peripheral T-cell lymphomas (PTCL) represent a heterogeneous group of rare malig- nancies that with the exception of anaplastic lymphoma kinase expressing anaplastic large ...
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High-Throughput Sequence Analysis of Peripheral T-Cell Lymphomas Indicates Subtype-Specific Viral Gene Expression Patterns and Immune Cell Microenvironments
... EBV-positive PTCL samples, as well as in the EBV-positive Burkitt lymphoma-derived Akata cell line, before and after induction of the lytic cycle with anti-human IgG (77, ...host cell regulatory ...
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<p>TLR4 expression correlated with PD-L1 expression indicates a poor prognosis in patients with peripheral T-cell lymphomas</p>
... in PTCL affects the proliferation, invasion, and drug resistance of tumor cells, and targeted therapy for TLR4 may become a promising potential therapeutic target for ...non-small cell lung cancer (NSCLC), ...
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New molecular insights into peripheral T cell lymphomas
... for PTCL-NOSs, but none of the proposed systems has completely achieved such a ...for PTCL-Unspecified (PIT), including age >60, Eastern Cooperative Oncology Group (ECOG) ≥1, elevated LDH levels, and ...
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Recombinative events of the T cell antigen receptor delta gene in peripheral T cell lymphomas
... beta PTCL displayed biallelic and monoallelic deletions; a monoallelic V delta 1 J delta 1 rearrangement was observed in 1 case and a monoallelic germ line configuration in 7 ...delta PTCL displayed ...
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Clinicopathological Correlation and Outcome in peripheral T cell lymphomas (PTCL): A Retrospective study
... T cell lymphomas of adaptive immunity are mainly seen in adults and are of nodal ...helper T cells (TFH) are a subset of CD4 cells seen in germinal ...Angioimmunoblastic T-cell ...
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An update on the management of peripheral T-cell lymphoma and emerging treatment options
... Peripheral T-cell lymphomas (PTCLs) are a subset of non-Hodgkin’s lymphomas (NHLs) that arise from lymphocytes at the post-thymic stage of maturation, which display T-cell ...
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An affinity/avidity model of peripheral T cell regulation
... B cell Ig and the TCR repertoire change and become more specific and composed of less diverse and higher–affinity/avidity clones responding to the same antigen ...
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T-Cell B-Rich Lymphoma Presenting as Renal Colic with Positivity of CD3 TCRBCL, CD3 positive
... Unusual symptom with systemic examination led to early detection of a high-grade malignancy. Primary splenic T/HRLBCL is an uncommon hematologic neoplasm. However, its diagnosis forms a major dilemma for ...
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A Five Year Retrospective Study of Spectrum of Cutaneous Lymphomas presenting to a Tertiary Care Centre
... A 41 year old female patient from Mizoram with clinically suspected CD30 LPD presented with multiple papules and plaques on extremities since 2 months. There was associated mild lymphadenopathy and mild pleural effusion. ...
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Tandemization of a Subregion of the Enhancer Sequences from SRS 19-6 Murine Leukemia Virus Associated with T-Lymphoid but Not Other Leukemias
... lymphomas showed evidence of enhancer rearrangements. Novel PCR products from each of the T-cell lymphoma-con- taining tumors were cloned, and their nucleotide sequences were determined. The ...
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GATA3 expression correlates with poor prognosis and tumor- associated macrophage infiltration in peripheral T cell lymphoma
... Peripheral T cell lymphoma (PTCL), which is common in Asia [1], is an aggressive form of lymphoma associated with poor patient ...with PTCL-not otherwise specified (PTCL-NOS) ...
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The IgH 3’ regulatory region influences lymphomagenesis in Igλ-Myc mice
... The IgH 3’regulatory region (3’RR), encompassing the four transcriptional enhancers hs3a-hs1,2-hs3b-hs4, has a key role on class switch recombination, somatic hypermutation, IgH transcription and B-cell fate. In ...
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CD30 expression in extranodal natural killer/T-cell lymphoma, nasal type among 622 cases of mature T-cell and natural killer-cell lymphoma at a single institution in South China
... including cell cycle arrest, apoptosis, and acti- vation of the pro-survival transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells ...in T cells and NK cells [13]. Among ...
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LKB1 is essential for the proliferation of T cell progenitors and mature peripheral T cells
... asymmetric cell division may control T lymphocyte fate [11, 30]. In mature T cells, the a 1 AMPK isoform is expressed and is activated by TCR triggering via calcium/calmodulin dependent kinase ...
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Molecular advances in cutaneous T-cell lymphoma
... malignant T cells driven by hyperactive JAK kinases ...CTCL cell lines bearing gain-of-function point mutations in JAK3 are sensitive to these compounds, opening the possibility for their potential use in ...
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