Purine nucleotide
Endothelial cell tolerance to hypoxia Potential role of purine nucleotide phosphates
... investigate potential mechanisms by which PAEC maintain cellular and functional integrity under these conditions, we compared the turnover of adenine and guanine nucleotides in hypoxia tolerant PAEC and in ...
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Mutation of a consensus purine nucleotide binding site in the adeno-associated virus rep gene generates a dominant negative phenotype for DNA replication.
... 1764-1770 0022-538X/90/041764-07$02.00/0 Copyright © 1990, American Society for Microbiology Mutation of a Consensus Purine Nucleotide Binding Site in the Adeno-Associated Virus rep Gene[r] ...
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Characterisation of multiple substrate specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism
... tracellular nucleotide pyrophosphatases/phosphodiesterases Npp1/Npp2 (17), scavenger mRNA decapping hydrolase Dcs1 (18) or heterodimeric enzyme form Dcs1/Dcs2 (19), phosphor- ibosyl-ATP pyrophosphatase His4 (20) ...
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Disruption of the purine nucleotide cycle by inhibition of adenylosuccinate lyase produces skeletal muscle dysfunction
... the purine nucleotide cycle is important in normal skeletal muscle ...the purine nucleotide cycle on muscle ...the purine nucleotide ...
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The purine nucleotide cycle A pathway for ammonia production in the rat kidney
... Particle-free extracts prepared from kidney cortex of rat catalyze the formation of ammonia via the purine nucleotide cycle. The cycle generates ammonia and fumarate from aspartate, using catalytic amounts ...
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Disruption of the Purine Nucleotide Cycle: A POTENTIAL EXPLANATION FOR MUSCLE DYSFUNCTION IN MYOADENYLATE DEAMINASE DEFICIENCY
... total purine content of the muscle fell to 21% of ...adenine nucleotide pool in this patient was delayed compared to controls, and ATP content had only returned to 68% of control at 165 min after ...the ...
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Plasma membrane located purine nucleotide transport proteins are key components for host exploitation by microsporidian intracellular parasites
... of nucleotide transport (NTT) proteins, homologues of which are conserved on all microsporidian ...of purine nucleotide must be imported, we detected transport of adenine and guanine nucleotides by ...
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THE EFFECT OF SPRINT TRAINING ON HUMAN SKELETAL MUSCLE PURINE NUCLEOTIDE METABOLISM
... Eight untrained subjects (six male and two female), performed a 30 s maximal sprint bout on a bicycle ergometer before and after a seven week intense sprint training regime. Venous blo[r] ...
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FACTORS INFLUENCING MUSCLE PURINE NUCLEOTIDE METABOLISM
... urinary purine (inosine + Hx + uric acid) excretion, a marker of whole-body purine loss, tended to be greater ...in purine excretion (Sorensen and Levison, ...
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The genetic and functional basis of purine nucleotide feedback resistant phosphoribosylpyrophosphate synthetase superactivity
... of purine nucleoside diphosphate inhibitor-resistance comparable to that found in cells of the respective ...by purine nucleotides and activation by inorganic ...
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ACCELERATED TURNOVER OF PHOSPHORIBOSYLPYROPHOSPHATE, A PURINE NUCLEOTIDE PRECURSOR, IN CERTAIN GOUTY SUBJECTS
... The present study demonstrates that gouty subjects who excrete excessive quantities of uric acid in urine also convert a greater fraction of an administered dose of glucose-U-C14 to phos[r] ...
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Myoadenylate deaminase deficiency Functional and metabolic abnormalities associated with disruption of the purine nucleotide cycle
... In contrast, muscle content of creatine phosphate, ATP, IMP, adenosine, inosine, and hypoxanthine changed in patients from one or both groups following exercise, and comparison ofthe cha[r] ...
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Selective expression of phosphoribosylpyrophosphate synthetase superactivity in human lymphoblast lines
... and purine nucleotide synthesis and express four classes of kinetic derangement underlying enzyme superactivity: increased maximal reaction velocity (catalytic defect); inhibitor resistance ...
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Purine nucleotides and their metabolites in patients with type 1 and 2 diabetes mellitus
... HPLC. Purine concentrations were determined in the eryt- hrocytes of 36 type 1 and 40 type 2 diabetic ...rine nucleotide degradation, suggests serious energy metabolism disruptions in ...erythrocyte ...
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Decreased erythrocyte nucleoside transport and hENT1 transporter expression in glucose 6-phosphate dehydrogenase deficiency
... intracellular purine nucleotide pool and, through the action of purine nucleoside phosphorylase, may exploit the pentose moiety for energy ...decreased purine transport could be of ...
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Vol 3, No 9 (2014)
... the purine nucleotide catabolism, and so significant amounts are converted to xanthine and enter the catabolic pathway via ...the purine ring is a crucial step in determining whether purine ...
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Mutation of lysine 405 to serine in the parvovirus H-1 NS1 abolishes its functions for viral DNA replication, late promoter trans activation, and cytotoxicity.
... In this article, we have presented evidence that the mutation of lysine 405 to serine in the putative purine nucleotide-binding site of the parvovirus H-1 NS1 gene abolished viral DNA ex[r] ...
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High Frequency Variation of Purine Biosynthesis Genes Is a Mechanism of Success in Campylobacter jejuni
... in purine bio- synthesis have been shown to have genome-wide mutational con- sequences in other organisms (19), purine biosynthesis mutants could be potential mutator ...
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THE EXTENT OF THE ENZYMATIC DEGRADATION OF DESOXYRIBONUCLEIC ACID (DNA) IN PURULENT EXUDATES BY STREPTODORNASE
... The latter tococcal desoxyribonuclease 5 into sites of are attacked by a purine nucleosidase with the purulent exudation, produces a rapid degradation liberation of the free purine bases[r] ...
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Canine cyclic hematopoiesis is associated with abnormal purine and pyrimidine metabolism
... and purine nucleoside phosphorylase deficiencies, we hypothesized that abnormal purine or pyrimidine metabolism might be present in these ...erythrocyte purine and pyrimidine nucleotide levels ...
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