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Py-Im Polyamide

Biological Activity of a Py-Im Polyamide Androgen Receptor Antagonist

Biological Activity of a Py-Im Polyamide Androgen Receptor Antagonist

... hairpin, Py-Im polyamide antagonists of AR-driven gene expression on the growth and viability of prostate cancer ...to polyamide treatment occurs in S- phase, not in G 0 /G 1 . The ...

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Biological Activity of Pyrrole-Imidazole Polyamides in vivo

Biological Activity of Pyrrole-Imidazole Polyamides in vivo

... of Py-Im PA compounds results in allosteric changes to the DNA helix that interferes with DNA-protein interactions and modifies gene expression ...of Py-Im polyamides in xenografts (20, 26, ...

208

Activity of Py Im Polyamides in Anti Androgen Resistant Prostate Cancer Models

Activity of Py Im Polyamides in Anti Androgen Resistant Prostate Cancer Models

... Py-Im polyamide ARE-1 has been previously shown to exhibit antiproliferative activity towards several models of prostate cancer including LNCaP, LNCaP-AR, VCaP, and ...

114

Synthesis and Biological Studies of DNA binding Cyclic Py Im Polyamides

Synthesis and Biological Studies of DNA binding Cyclic Py Im Polyamides

... conditions. Py-Im polyamide 1, designed to bind the 5’- WGWWCW-3’ sequence found in the consensus ARE, was previously shown to downregulate the expression of AR-driven genes in LNCaP prostate cancer ...

176

Polyamide/nano mixed matrix membranes for pervaporation dehydration Ethylene glycols

Polyamide/nano mixed matrix membranes for pervaporation dehydration Ethylene glycols

... In the current study, polyamide/nano silica MMMs prepared for PV dehydration of ethylene glycols. Silica nano particles, with sizes smaller than 100 nm, were dispersed in the matrix of polyamide directly ...

8

Hypertension Risk with Abacavir Use among HIV Infected Individuals: A Nationwide Cohort Study

Hypertension Risk with Abacavir Use among HIV Infected Individuals: A Nationwide Cohort Study

... the history of acute kidney failure and ESRD prior to cohort entry in order to adjust for renal function and chronic ob- structive pulmonary disease in order to adjust for smoking status using diagnostic codes that were ...

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Roles of the ITAM and PY Motifs of Epstein-Barr Virus Latent Membrane Protein 2A in the Inhibition of Epithelial Cell Differentiation and Activation of β-Catenin Signaling

Roles of the ITAM and PY Motifs of Epstein-Barr Virus Latent Membrane Protein 2A in the Inhibition of Epithelial Cell Differentiation and Activation of β-Catenin Signaling

... The Epstein-Barr virus (EBV) is a very successful human herpesvirus that has infected more than 90% of the world’s adult population (16). The virus is capable of both lytic and latent forms of infection, and the virus is ...

8

Interactions between Nanoclays and Flame Retardant Additives in Polyamide 6 and Polyamide 6.6 Films

Interactions between Nanoclays and Flame Retardant Additives in Polyamide 6 and Polyamide 6.6 Films

... Figure 1 shows that the bimodal structure of the fusion endotherm for the pure polyamide 6.6 film, presumably the α-form, changes to a single peak when the nanoclay is present. The change in shape is indicative of ...

36

Skeletally Modified Polyamide Flame Retardant Coatings

Skeletally Modified Polyamide Flame Retardant Coatings

... It is observed that phosphorus modified polyamide exhibits better flame retardant behaviour V0 rating than unmodified polyamide V2 rating indicating the superior char protecting nature o[r] ...

7

Home Automation Using Py-Ardomotics

Home Automation Using Py-Ardomotics

... Cloud-based home appliance monitoring and controlling System is design and implement a home gateway to collect metadata from home appliances and send to the cloud[r] ...

5

A cloned polyoma DNA fragment representing the 5' half of the early gene region is oncogenic.

A cloned polyoma DNA fragment representing the 5' half of the early gene region is oncogenic.

... The U peptide has been By using a recombinant plasmid, pPB90, con- identified in the middle T Ag found in Py-6, a taining Py DNA extending clockwise from the Py-transformed mouse cell li[r] ...

9

Structural Modifications to DNA Binding Polyamides for Improved Biological Activity in Cell Culture

Structural Modifications to DNA Binding Polyamides for Improved Biological Activity in Cell Culture

... To examine the effect of moving the carboxylic acid group from the meta to the para position on the ring relative to the amide linkage, the terephthalic acid tail was selected. -polyamide conjugates were ...

123

Ferromagnetic Resonance to Investigate Spin Pumping in Permalloy Multilayers

Ferromagnetic Resonance to Investigate Spin Pumping in Permalloy Multilayers

... for Py/Ir and Py/Cu/Ir multilayers as a function of Ir ...sample Py demonstrated a damping parameter consistent with other investigations ...of Py and ...the Py/Ir samples that was not ...

87

Murine polyomavirus and simian virus 40 large T antigens produce different structural alterations in viral origin DNA.

Murine polyomavirus and simian virus 40 large T antigens produce different structural alterations in viral origin DNA.

... and Py replicons show marked host species specificity in vivo and in vitro (references 39 and 40 and references ...similarly, Py cannot support Py ori DNA synthesis in human or monkey cells or cell ...

7

Effect of Acidic Catalyst on Properties of Novel Conductive Copolymer Films Made of Pyrrole and Formyl Pyrrole

Effect of Acidic Catalyst on Properties of Novel Conductive Copolymer Films Made of Pyrrole and Formyl Pyrrole

... creased with increase of the catalyst amounts and became constant over 13 mmol. The high yield indicated that high concentration of the catalyst could consume both monomers to polymerize Py and FPy for the ...

7

E1A represses wild-type and F9-selected polyomavirus DNA replication by a mechanism not requiring depression of large tumor antigen transcription.

E1A represses wild-type and F9-selected polyomavirus DNA replication by a mechanism not requiring depression of large tumor antigen transcription.

... Adenovirus ElA proteins repress transcriptional activation of various enhancers, including those of Py, and can stimulate DNA replication in quiescent cells, but ElA effects on Py DNA re[r] ...

8

Consequences of a subtle sialic acid modification on the murine polyomavirus receptor.

Consequences of a subtle sialic acid modification on the murine polyomavirus receptor.

... of Py to 25,000 sialylated receptors on unmodified 3T6 ...of Py infection by the modified sialic acids is medi- ated by a reduction in virus-receptor interaction, binding as- says using purified virus ...

10

The polyomavirus early region gene in transgenic mice causes vascular and bone tumors.

The polyomavirus early region gene in transgenic mice causes vascular and bone tumors.

... However, we have not detected gross differences in expression levels between the Py early region transgene and the Py cDNA transgenes in either tumors or unaffected tissue, and the expre[r] ...

10

Preclinical Study of DNA-Recognized Peptide Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in Common Marmoset

Preclinical Study of DNA-Recognized Peptide Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in Common Marmoset

... with Polyamide (1 mg/kg/week, for 4 weeks) from 4 weeks after the start of CsA ...with Polyamide (1 mg/kg/week) through the tail vein for 4 weeks from 1 week after the ...

25

Polyomavirus growth and persistence in Friend erythroleukemic cells.

Polyomavirus growth and persistence in Friend erythroleukemic cells.

... The long persistence of Py particles in FL-Py cells grown in medium containing anti-Py serum and the rescue of viral particles in FL infection by the PytsA mutant cannot be explained wit[r] ...

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